Loading…

Protocol - Menstrual History

Add to My Toolkit
Description:

Females answer questions about the frequency and regularity of her menstrual cycle and whether any irregularities were due to breastfeeding. Females also answer questions about whether their periods have stopped.

Protocol:

1. Since the age of 18, have you ever experienced a time interval of 3 or more months when you did not have a menstrual period? [PROBE: IF "YES": Was this one time only or more than once?]

[ ] 1 No (Skip to question 4)

[ ] 2 Yes One time only

[ ] 3 Yes More than once

[ ] -8 Don’t know (Skip to question 4)

2. Were you breastfeeding at the time?

[ ] 1 No (Skip to question 4)

[ ] 2 Yes

[ ] -8 Don’t know (Skip to question 4)

3. Were you breastfeeding or pregnant every time this happened?

[ ] 1 No

[ ] 2 Yes

[ ] -8 Don’t know

4. During ages 18-22 what was the pattern of your menstrual cycles? (excluding time around pregnancies)

[ ] Regular (within 8 days)

[ ] Usually irregular

[ ] Always irregular

[ ] No periods

5. On average, during the last year, how many days were there in a typical menstrual cycle, that is, from the beginning of bleeding of one menstrual period to the beginning of bleeding of the next period?

[ ] 1 Less than 21 days

[ ] 2 21-25 days

[ ] 3 26-32 days

[ ] 4 33-35 days

[ ] 5 36-90 days

[ ] 6 More than 90 days

[ ] 7 Too variable to say

[ ] -8 Don’t know

6. Have your menstrual periods stopped permanently?

[ ] Yes, no menstrual periods

[ ] Yes, but have periods now due to female hormones (end)

[ ] No (end)

[ ] Not sure (end)

7. How old were you when your periods stopped?

[ ] Less than 35

[ ] 35-39

[ ] 40-44

[ ] 45-49

[ ] 50-54

[ ] 55 or more

Protocol Name from Source:

Nurses’ Health Study (NHS), Black Women’s Health Study (BWHS), Study of Women Across the Nation (SWAN)

Availability:

Publicly available

Personnel and Training Required

None

Equipment Needs

Pencil and paper

Requirements
Requirement CategoryRequired
Major equipment No
Specialized training No
Specialized requirements for biospecimen collection No
Average time of greater than 15 minutes in an unaffected individual No
Mode of Administration

Self-administered questionnaire

Life Stage:

Adult

Participants:

Adult females, ages 18+

Specific Instructions:

The Expert Review Panel recommends that question 4 be framed in the context of when the subject was not taking contraceptives.

Selection Rationale

No single protocol was found to cover menstrual history through the life cycle. Therefore the PhenX Reproductive Health Working Group used protocols from three well established sources, the Study of Women’s Health Across the Nation (SWAN), the Nurses’ Health Study (NHS), and the Black Women’s Health Study (BWHS) to address disruptions and the end to menstrual cycles.

Language

English

Standards
StandardNameIDSource
Common Data Elements (CDE) Female Menstrual Cycle History 3007481 CDE Browser
Logical Observation Identifiers Names and Codes (LOINC) Menstrual hx proto 62668-9 LOINC
Process and Review

The Expert Review Panel #5 (ERP 5) reviewed the measures in the Reproductive Health domain.

Guidance from ERP 5 includes:

  • Revised descriptions of the measure

Back-compatible; no changes to Data Dictionary.

Previous version in Toolkit archive (link).

Source

Harvard Medical School. (n.d.). Nurses’ Health Study (NHS), Long Form 1988. Boston, MA: Author. Question number 20 (question 4). National Institute on Aging (NIA), National Institute of Nursing Research (NINR), National Institutes of Health (NIH), et al. (n.d.). Study of Women’s Health Across the Nation (SWAN) Baseline 08-19-04. Question numbers C20 (question 1), C20.1 (question 2), C20.2 (question 3), Question number C11 (question 5).

Slone Epidemiology Center at Boston University (n.d.). Black Women’s Health Study 1995. Boston, MA: Author. Question 21 (questions 6 and 7).

General References

Carroll, J., Saxena, R., & Welt, C. K. (2012). Environmental and genetic factors influence age at menarche in women with polycystic ovary syndrome. Journal of Pediatric Endocrinology and Metabolism, 25(5-6), 459-66.

Solomon, C. G., Hu, F. B., Dunaif, A., Rich-Edwards, J., Willett, W. C., Hunter, D. J., . . . Manson, J. E. (2001). Long or highly irregular menstrual cycles as a marker for risk of type 2 diabetes mellitus. JAMA, 286, 2421-2426.

Solomon, C. G., Hu, F. B., Dunaif, A., Rich-Edwards, J. E., Stampfer, M. J., Willett. W. C., . . . Manson, J. E. (2002). Menstrual cycle irregularity and risk for future cardiovascular disease. Journal of Clinical Endocrinology and Metabolism, 87, 2013-2017.

Carroll, J., Saxena, R., & Welt, C. K. (2012). Environmental and genetic factors influence age at menarche in women with polycystic ovary syndrome. Journal of Pediatric Endocrinology and Metabolism, 25(5-6), 459-66.

Protocol ID:

101101

Variables:
Export Variables
Variable NameVariable IDVariable DescriptionVersiondbGaP Mapping
PX101101_Menstrual_Cycle_Pattern_Age_18_22 PX101101040000 During ages 18-22 what was the pattern of your menstrual cycles? (excluding time around pregnancies) 4 N/A
PX101101_Menstrual_Cycle_Typical_Days_Average PX101101050000 On average, during the last year, how many days were there in a typical menstrual cycle, that is, from the beginning of bleeding of one menstrual period to the beginning of bleeding of the next period? 4 Variable Mapping
PX101101_Menstrual_Period_Stop_Age PX101101070000 How old were you when your periods stopped? 4 Variable Mapping
PX101101_Menstrual_Period_Stop_Permanently PX101101060000 Have your menstrual periods stopped permanently? 4 N/A
PX101101_No_Menstrual_Period_3_More_Months PX101101010000 Since the age of 18, have you ever experienced a time interval of 3 or more months when you did not have a menstrual period? 4 Variable Mapping
PX101101_No_Menstrual_Period_Breastfeeding PX101101020000 Were you breastfeeding at the time? 4 N/A
PX101101_No_Menstrual_Period_Breastfeeding_Pregnant_Always PX101101030000 Were you breastfeeding or pregnant every time this happened? 4 N/A
Research Domain Information
Measure Name:

Menstrual History

Release Date:

April 11, 2017

Definition

Questions to determine a female’s menstrual history including disruptions to her menstrual cycle.

Purpose

These questions assess females’ menstrual history.

Keywords

Reproductive health, menstrual periods, Study of Women Across the Nation, SWAN, Black Women’s Health Study, BWHS, Nurses’ Health Study, NHS