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The CHRIS study is a longitudinal, population-based study to assess the etiological role of genetic and environmental risk factors, and their interactions, on cardiovascular, neurological, and metabolic conditions.
This project will elucidate the genetic underpinnings of comorbid mood and substance use disorders, through analyses in large families that include multiple individuals affected with both types of disorder.
This study aims to identify new genetic variants associated with nicotine dependence, by leveraging interactions with well-established variants from nicotinic acetylcholine receptor genes. To conduct this study, we have assembled >19,000 Caucasians and >4,000 African Americans, who all have genome-wide genotypes and Fagerstrom Test for Nicotine Dependence data, from our own cohorts and others from the database of Genotypes and Phenotypes (dbGaP). Results of this study may be used to better understand the genetic risk factors for nicotine dependence and smoking cessation and ultimately reduce the burden of smoking health consequences.
The GuLF STUDY is focused on prospectively determining both physical and mental health effects related to the 2010 Deepwater Horizon oil spill and is collecting information that can be used by individuals, communities and governments to better understand the consequences of oil spills and plan for future disasters.
The goals of AIDHS/SDS are to discover unique genetic markers associated with type 2 diabetes (T2D) and related metabolic and lipid traits by performing genome-wide association scans (GWAS) and validation studies.
GARM II is a nationwide research study about age-related macular degeneration in the next generation of adults (49 to 65 years old). The purpose of this study is to identify the hereditary and exposure risk factors that lead to the development of ARM (Age related maculopathy).
A multi-centered prospective case-control study of Intracerebral Hemorrhage. We are collecting 1000 Whites, 1000 African American's and 1000 Hispanics and 3000 demographically matched controls. We will identify differences in risk factor distribution by race, ethnicity and location of ICH using case-control design
Pediatric Imaging, Neurocognition, and Genetics (PING) is a multi-site cross-sectional study of typically developing children, adolescents, and young adults ranging in age from 3 to 20. The primary goal of PING is to create a pediatric imaging-genomics database of approximately 1400 cases that is freely available to the scientific community.
The Consortium for Neuropsychiatric Phenomics comprises 8 linked grants awarded under the aegis of the NIH Roadmap Initiative. The PhenX supplement grant was awarded to the Human Translational Applications Core, a center core that conducted extensive phenotyping of more than 1000 healthy volunteers aged 21 to 50 in the Los Angeles metropolitan area from 2007 to 2012. The phenotyping efforts focused on two primary themes - memory mechanisms and response inhibition mechanisms - and participants completed approximately 12 hours of cognitive phenotyping, and a subset of these participants received also several hours of neuroimaging procedures to examine brain structure and function (descriptions of these procedures are available at www.phenomics.ucla.edu).
The study was designed to validate a hypothesized gene/environment/self-regulation risk phenotype (a combination of individual differences in regulatory focus, COMT genotype, and chronic failure to attain a particular kind of personal goal) that is believed to confer vulnerability to failures of self-regulation, which in turn increase risk for psychopathology with significant public health implications such as aggression, gambling, and excessive use of alcohol and other drugs.
The goal of this study is to search for a better understanding of the effects of the determinants of healthy longevity. In the 2011-2012 wave of survey, 13 PhenX measures were applied in our CLHLS data collection, which were adapted to the context of Chinese culture and language
Glaucoma is a major cause of blindness. The inability to predict a patient's IOP response to medications is a critical barrier for the clinician to consistently provide highly effective IOP-based treatments. Current trial-and-error approaches to glaucoma management are inefficient and have not addressed this barrier as there are no predictive factors for drug response. Our long-term goal is to improve outcomes by identifying biomarkers and environmental factors that profile a patient at risk for glaucoma by age-of-onset, rate of disease progression, "poor response" to treatment, and large IOP fluctuation. Our purpose of this research project is to address this critical barrier by focusing on physiological factors that predict IOP response to drugs.
The PhenX Toolkit was designed to collect data for some of the PhenX measures known to be associated with age-related cataract. This will demonstrate the utility of the PhenX measures in a large-scale biobank and leverage the resources of eMERGE to facilitate additional gene/environment analyses for cataract. These measures were also chosen to allow collaboration among the PhenX RISING sites. Copies of the PhenX measures were mailed to the 3737 living subjects in PMRP that have GWAS data available and have agreed to be re-contacted. The additional PhenX measures were added to enhance the ability to explore gene-environment interactions associated with cataract.
The Detroit Neighborhood Health Study (DNHS) is a prospective, representative longitudinal cohort study of predominantly African American adults living in Detroit, Michigan. The overall goal of the DNHS is to identify how genetic variation, lifetime experience of stressful and traumatic events, and features of the neighborhood environment predict psychopathology and behavior.