Protocol - Rheumatoid arthritis disease activity

Personnel and Training Required

Generally performed by rheumatologist or nurse who is trained in how to examine joints. Specialized training is required—although not for rheumatologists because the joint examination is a basic part of their training.

Equipment Needs

None

Requirements

Requirement Category	Required
Major equipment	No
Specialized training	Yes
Specialized requirements for biospecimen collection	No
Average time of greater than 15 minutes in an unaffected individual	No

Mode of Administration

Interviewer-administered questionnaire

Lifestage

Adolescent, Adult, Senior, Pregnancy

Participants

Patients with rheumatoid arthritis.

Selection Rationale

The Clinical Disease Activity Index (CDAI) assesses rheumatoid arthritis (RA) disease severity in an individual through clinical observation without requiring laboratory work thus providing immediate feedback to utilize in assessment of disease progression and treatment planning.

Language

English

Standards

Standard	Name	ID	Source

Derived Variables

None

Process and Review

Not applicable.

Protocol Name from Source

Clinical Disease Activity Index (CDAI)

Source

Aletaha, D., & Smolen, J. (2005). The Simplified Disease Activity Index (SDAI) and the Clinical Disease Activity Index (CDAI): A review of their usefulness and validity in rheumatoid arthritis. Clinical and Experimental Rheumatology, 23(5 Suppl. 39), S100–S108.

General References

Aletaha, D., Nell, V. P., Stamm, T., Uffman, M., Pflugbeil, S., Machold, K., & Smolen, J. S. (2005). Acute phase reactants add little to composite disease activity indices for rheumatoid arthritis: Validation of a clinical activity score. Arthritis Research & Therapy, 7(4), R796–R806.

Heegaard, C., Dreyer, L., Egsmose, C., & Madsen, O. R. (2013). Test-retest reliability of the Disease Activity Score 28 CRP (DAS28-CRP), the Simplified Disease Activity Index (SDAI) and the Clinical Disease Activity Index (CDAI) in rheumatoid arthritis when based on patient self-assessment of tender and swollen joints. Clinical Rheumatology, 32(10), 1493–1500.

Salaffi, F., Di Carlo, M., Farah, S., Marotto, D., Atzeni, F., & Sarzi-Puttini, P. (2021). Rheumatoid arthritis disease activity assessment in routine care: Performance of the most widely used composite disease activity indices and patient-reported outcome measures. Acta Bio Medica, 92(4), e2021238.

Smolen, J. S., & Aletaha, D. (2014). Scores for all seasons: SDAI and CDAI. Clinical and Experimental Rheumatology, 32(5 Suppl. 85), S-75–S-79.

Protocol ID

171901

Variables

Export Variables

Variable Name	Variable ID	Variable Description	dbGaP Mapping
PX171901_Rheumatoid_Arthritis_Disease_Activity_Patient_Assessment
	PX171901530000	Considering all the ways your arthritis more affects you, rate how well you are doing on the following scale: show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Patient_Assessment_Date_Birth
	PX171901550000	Date of Birth:	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Patient_Assessment_Date_Today
	PX171901560000	Today's Date	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Patient_Assessment_Name
	PX171901540000	Your Name:	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Provider_Assessment
	PX171901570000	Rate how well the patient is doing on the more following scale: show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Left_Elbow
	PX171901020000	Please indicate if the following joint feels more swollen: Left Elbow show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Left_MCP 1
	PX171901040000	Please indicate if the following joint feels more swollen: Left MCP 1 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Left_MCP 2
	PX171901050000	Please indicate if the following joint feels more swollen: Left MCP 2 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Left_MCP 3
	PX171901060000	Please indicate if the following joint feels more swollen: Left MCP 3 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Left_MCP 4
	PX171901070000	Please indicate if the following joint feels more swollen: Left MCP 4 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Left_MCP 5
	PX171901080000	Please indicate if the following joint feels more swollen: Left MCP 5 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Left_PIP 1
	PX171901090000	Please indicate if the following joint feels more swollen: Left PIP 1 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Left_PIP 2
	PX171901100000	Please indicate if the following joint feels more swollen: Left PIP 2 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Left_PIP 3
	PX171901110000	Please indicate if the following joint feels more swollen: Left PIP 3 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Left_PIP 4
	PX171901120000	Please indicate if the following joint feels more swollen: Left PIP 4 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Left_PIP 5
	PX171901130000	Please indicate if the following joint feels more swollen: Left PIP 5 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Left_Shoulder
	PX171901010000	Please indicate if the following joint feels more swollen: Left Shoulder show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Left_Wrist
	PX171901030000	Please indicate if the following joint feels more swollen: Left Wrist show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Right_Elbow
	PX171901150000	Please indicate if the following joint feels more swollen: Right Elbow show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Right_MCP 1
	PX171901170000	Please indicate if the following joint feels more swollen: Right MCP 1 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Right_MCP 2
	PX171901180000	Please indicate if the following joint feels more swollen: Right MCP 2 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Right_MCP 3
	PX171901190000	Please indicate if the following joint feels more swollen: Right MCP 3 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Right_MCP 4
	PX171901200000	Please indicate if the following joint feels more swollen: Right MCP 4 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Right_MCP 5
	PX171901210000	Please indicate if the following joint feels more swollen: Right MCP 5 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Right_PIP 1
	PX171901220000	Please indicate if the following joint feels more swollen: Right PIP 1 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Right_PIP 2
	PX171901230000	Please indicate if the following joint feels more swollen: Right PIP 2 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Right_PIP 3
	PX171901240000	Please indicate if the following joint feels more swollen: Right PIP 3 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Right_PIP 4
	PX171901250000	Please indicate if the following joint feels more swollen: Right PIP 4 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Right_PIP 5
	PX171901260000	Please indicate if the following joint feels more swollen: Right PIP 5 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Right_Shoulder
	PX171901140000	Please indicate if the following joint feels more swollen: Right Shoulder show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Swollen_Right_Wrist
	PX171901160000	Please indicate if the following joint feels more swollen: Right Wrist show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Left_Elbow
	PX171901280000	Please indicate if the following joint feels more tender: Left Elbow show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Left_MCP 1
	PX171901300000	Please indicate if the following joint feels more tender: Left MCP 1 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Left_MCP 2
	PX171901310000	Please indicate if the following joint feels more tender: Left MCP 2 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Left_MCP 3
	PX171901320000	Please indicate if the following joint feels more tender: Left MCP 3 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Left_MCP 4
	PX171901330000	Please indicate if the following joint feels more tender: Left MCP 4 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Left_MCP 5
	PX171901340000	Please indicate if the following joint feels more tender: Left MCP 5 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Left_PIP 1
	PX171901350000	Please indicate if the following joint feels more tender: Left PIP 1 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Left_PIP 2
	PX171901360000	Please indicate if the following joint feels more tender: Left PIP 2 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Left_PIP 3
	PX171901370000	Please indicate if the following joint feels more tender: Left PIP 3 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Left_PIP 4
	PX171901380000	Please indicate if the following joint feels more tender: Left PIP 4 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Left_PIP 5
	PX171901390000	Please indicate if the following joint feels more tender: Left PIP 5 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Left_Shoulder
	PX171901270000	Please indicate if the following joint feels more tender: Left Shoulder show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Left_Wrist
	PX171901290000	Please indicate if the following joint feels more tender: Left Wrist show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Right_Elbow
	PX171901410000	Please indicate if the following joint feels more tender: Right Elbow show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Right_MCP 1
	PX171901430000	Please indicate if the following joint feels more tender: Right MCP 1 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Right_MCP 2
	PX171901440000	Please indicate if the following joint feels more tender: Right MCP 2 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Right_MCP 3
	PX171901450000	Please indicate if the following joint feels more tender: Right MCP 3 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Right_MCP 4
	PX171901460000	Please indicate if the following joint feels more tender: Right MCP 4 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Right_MCP 5
	PX171901470000	Please indicate if the following joint feels more tender: Right MCP 5 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Right_PIP 1
	PX171901480000	Please indicate if the following joint feels more tender: Right PIP 1 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Right_PIP 2
	PX171901490000	Please indicate if the following joint feels more tender: Right PIP 2 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Right_PIP 3
	PX171901500000	Please indicate if the following joint feels more tender: Right PIP 3 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Right_PIP 4
	PX171901510000	Please indicate if the following joint feels more tender: Right PIP 4 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Right_PIP 5
	PX171901520000	Please indicate if the following joint feels more tender: Right PIP 5 show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Right_Shoulder
	PX171901400000	Please indicate if the following joint feels more tender: Right Shoulder show less	N/A
PX171901_Rheumatoid_Arthritis_Disease_Activity_Tender_Right_Wrist
	PX171901420000	Please indicate if the following joint feels more tender: Right Wrist show less	N/A

Bone and Joint

Measure Name

Rheumatoid arthritis disease activity

Release Date

October 21, 2022

Definition

A hands-on assessment, performed by a trained evaluator (usually a rheumatologist), of tenderness and swelling in 28 joints that are associated with rheumatoid arthritis disease activity. In addition to the clinical observation, there is a 10-point scale for the evaluator to estimate the activity of the patient’s arthritis and a similar scale for the patient to rate how active they believe their arthritis is.

Purpose

To screen for and assess the progression of disease activity for rheumatoid arthritis.

Keywords

Rheumatoid arthritis, Clinical Disease Activity Index (CDAI), bone and joint, pain

Measure Protocols

Protocol ID	Protocol Name
171901	Rheumatoid arthritis disease activity

Publications

There are no publications listed for this protocol.