Protocol - Disorders of Respiratory Control with Inherent Autonomic Dysregulation
- Personal and Family History of Respiratory Symptoms/Diseases - Adult
- Personal and Family History of Respiratory Symptoms/Diseases - Child
- Quality of Life as Affected by Respiratory Disease
- Respiratory Rate - Adult
- Respiratory Rate - Child
- Respiratory Rate - Infant
- Sleep Apnea - Adult
- Sleep Apnea - Child
Description
The American Thoracic Society (ATS) policy statement regarding Congenital Central Hypoventilation Syndrome (CCHS) is a comprehensive guide for diagnosing an individual with CCHS by evaluating their phenotype and determining their paired-like homeobox gene (PHOX2B) genotype. Evaluation via the ATS statement involves completion of (1) the Autonomic Nervous System Questionnaire (ANSQ), (2) stepwise PHOX2B genetic testing, and (3) physiologic and other clinical testing.
- The ANSQ is a self-administered questionnaire including 46 questions with the purpose of measuring Autonomic Nervous System Dysregulation. It is also available as a REDCap Registry through a research protocol.
- Genetic testing to identify CCHS-related mutations in the PHOX2B gene involves step-wise testing with Step 1. PHOX2B Screening Test, Step 2. PHOX2B Sequencing Test, and Step 3. PHOX2B MLPA Test.
- Physiologic and other clinical testing during wakefulness and sleep and other testing to evaluate patients in activities of daily living in keeping with the ATS 2010 Statement on CCHS.
Specific Instructions
The Rare Genetic Conditions Working Group (WG) acknowledges that (1) the Autonomic Nervous System Questionnaire (ANSQ) can be administered manually or through a Congenital Central Hypoventilation Syndrome (CCHS) REDCap Registry; (2) Genetic PHOX2B testing sites for step-wise testing are described in the 2010 American Thoracic Society (ATS) Statement on CCHS and are provided at www.genetests.org; and (3) the physiologic and autonomic testing would need to be provided in a laboratory with experience in polysomnography with application in wakefulness and sleep-and, ideally, in a center with extensive expertise in CCHS. The other clinical testing would need to be provided in a pediatric specialty program with extensive experience in ventilator management for children and if possible adults with disordered respiratory control and autonomic regulation.
Additionally, the WG recommends the PhenX Family History measure be used to capture information on family members in reference to the family tree in the ANSQ.
Availability
Protocol
Autonomic Nervous System Questionnaire (ANSQ):
First we are going to draw your family tree. Be sure to include any abortions (spontaneous and elective) and any infant deaths including sudden infant death syndrome (SIDS). (See step by step family tree diagram.)
Now that we’ve drawn your family tree, I’m going to ask you specific questions that you should answer first about the individual with CCHS (might be you or your child) and then about anyone you’ve described in your family tree.
Are you or any other adults (18 years of age or older) in your family:
Over 6’2?
Under 4’8?
Over 200 lbs?
Under 90 lbs?
Have any minors (under 18 years of age) in your family had atypical growth patterns?
Delayed growth?
Accelerated growth?
Have you or anyone in your family ever been diagnosed with obesity?
Yes ___ No ___
Do you or anyone in your family have growth hormone deficiency or excess?
Yes ___ No ___
Do you or anyone in your family have any known significant medical problems?
Yes ___ No ___
Remember when you answer these questions we would like to know if you ever experienced these problems at any time - as an infant, child or adult. Also, tell me first about you and then about any of the people you told me about when we drew the family tree.
Such as:
Have you ever had low blood sugar (hypoglycemia) or high blood sugar?
Diabetes: childhood onset, pregnancy related, or adult onset
Thyroid disease
Phenochromocytoma
Parathyroid tumor
Carcinoid
Tumors of neural crest origin such as neuroblastoma,
ganglioneuroma, ganglioneuroblastoma
Heart disease:
Hypertension
Cardiac pacemaker
Bypass surgery
Heart attack
Mitral valve prolapse
Cancer and type:
GI cancer - type
cancers of/in the chest
brain tumor
other cancers
Hearing problems:
Waardenberg syndrome - a white forelock of hair
GI problems:
Hirschsprung disease
Colic as an infant
Any unusual skin color - increase or decrease in pigmentation?
Are there any genetic disease that run in your family? Inborn errors?
Any history of Parkinson’s disease?
Have you ever had a wandering eye/told you have strabismus?
Other
Other
Other
| Use the following scoring system to rate the following questions: | |||
| Frequency Score: | 0= never or insignificant | Severity Score: | 0= never |
| 1= mild or infrequent (once per month) | 1= mild symptoms 2= moderate symptoms | ||
| 2= frequent (once per week) | 3= severe symptoms | ||
| 3= consistent once every 2-3 days | |||
| 4= consistent (every day) | |||
Cardiovascular System Questions:
Remember when you answer these questions we would like to know if you ever experienced these symptoms at any time - as an infant, child or adult. Also, tell me first about you and then about any of the people you told me about when we drew the family tree.
1. Have you experienced episodes of dizziness in the past?
Age at onset of symptoms
When do symptoms occur:
Are there ever any precipitating or aggravating factors:
Early morning
After a meal
Prolonged standing
Exertion/walking
Is the dizziness ever associated with:
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
2. Have you experienced episodes of blurred vision or glare in the past?
Age at onset of symptoms
When do symptoms occur
Associated with anything? Dizziness? Loss of consciousness?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
3. Have you experienced episodes of loss of consciousness in the past?
Age at onset of symptoms
When do symptoms occur
Associated with anything? Dizziness? Overheating? Blurred vision?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
4. Have you experienced throbbing pounding headaches (not migraine) in the past?
Are any associated with your face becoming pale or becoming flushed or with sweating
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
5. Have you ever had facial pallor - paleness of the face associated with sweating?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
6. Have you ever had really cold fingers or toes?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
7. Have you ever had Raynaud’s phenomenon where your fingers go white, then blue and red?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
8. Have you ever been told by a doctor that you have:
postural hypotension
vasovagal syncope
paroxysmal hypertension
cardiac dysrhythmia
decreased heart rate variability
altered vascularity of face
decreased perfusion to extremities
Gastrointestinal System Questions
With these questions we would like to know if you ever experienced these symptoms at any time - as an infant, child or adult. Also, tell me first about you and then about any of the people you told me about when we drew the family tree.
9. Have you ever had profuse oral secretions/drooling?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
10. Have you ever had dysphagia - difficulty swallowing?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
11. Have you ever had any of the following symptoms (gastroparesis)
Anorexia
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
Early satiety
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
Persistent sense of bloating/Fullness with abdominal distension
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
Frequent nausea
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
Recurrent vomiting
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
12. Have you ever had abdominal surgery? Do you have any scars on your body?
Date and reason
13. Have you ever been diagnosed or evaluated for Hirschsprung disease?
14. Have you ever had had constipation defined as inability to defecate without strenuous effort, presence of hard stools, bowel movements twice a week on average, regular use of mineral oil or other mild laxative?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for this?
If yes, was a diagnosis made?
15. Have you ever had (autonomic) diarrhea unrelated to a viral illness?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
16. Have you ever had abdominal pain? Have you experienced colic as an infant?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
Neurologic System Questions
Remember when you answer these questions we would like to know if you ever experienced these symptoms at any time - as an infant, child or adult. Also, tell me first about you and then about any of the people you told me about when we drew the family tree.
17. Have you ever had migraine or cluster headaches?
Age at onset of symptoms
When do symptoms occur
Associated with
ipsilateral (same side as the headache) eye watering
ipsilateral nasal drainage
miosis (pupil constriction)
ptosis (dropping eyelid)
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
18. Have you ever been told you had decreased muscle tone in your arms or legs?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
19. Have you ever had severe burning pain or causalgia of any body part? (For example - ears, fingers, toes, etc)
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
20. Have you ever had an altered perception of pain-either a high pain tolerance/not feel pain or a low pain tolerance/very sensitive to pain?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
Ocular Questions
Remember when you answer these questions we would like to know if you ever experienced these symptoms at any time - as an infant, child or adult. Also, tell me first about you and then about any of the people you told me about when we drew the family tree.
21. Do you have unequal pupils?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
22. Do you have droopy eyelids?
Right Left Both
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made? Did they call it ptosis?
23. Were you told that your eyes do not respond well to light?
Right Left Both
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
24. Do you have tightly constricted pupils?
Right Left Both
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made? Was this called miosis?
25. Have you had problems with tearing?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
26. Have you ever had trouble with your vision accommodating or converging, i.e. fixing your gaze from far to near?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
Psychological System Questions
Remember when you answer these questions we would like to know if you ever experienced these symptoms at any time - as an infant, child or adult. Also, tell me first about you and then about any of the people you told me about when we drew the family tree.
27. Have you ever had problems with anxiety?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
28. Have you ever been diagnosed as having a learning disability, either verbal or non-verbal?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Did you seek medical attention for these events?
If yes, was a diagnosis made?
Was medication such as ritalin? prozac? caffeine? ever prescribed?
29. Have you ever had problems with recognizing social cues around you?
Have you ever had problems making eye contact?
Do you comprehend facial expression, body language, gesture, and tone of voice?
Do you have social interests but lack the ability to initiate and maintain social relationships?
Renal and Urinary System Questions
Remember when you answer these questions we would like to know if you ever experienced these symptoms at any time - as an infant, child or adult. Also, tell me first about you and then about any of the people you told me about when we drew the family tree.
30. Have you ever had problems with retaining your urine or incomplete emptying of your bladder?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
31. Have you ever had problems with frequent urination?
During the day or at night?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
32. Have you ever had problems with urgency to urinate?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
33. Have you ever had problems with urinary incontinence?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
Reproductive System Questions
Remember when you answer these questions we would like to know if you ever experienced these symptoms at any time - as an infant, child or adult. Also, tell me first about you and then about any of the people you told me about when we drew the family tree
34. Have you ever had problems with loss of libido?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
35. Adult male only: Have you ever had problems with erection or ejaculation?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
36. Adult male only: Have you ever had problems with priapism (the penis remains erect when not in use)?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
Respiratory System Questions
Remember when you answer these questions we would like to know if you ever experienced these symptoms at any time - as an infant, child or adult. Also, tell me first about you and then about any of the people you told me about when we drew the family tree.
37. Have you ever had problems with stridor?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
38. Do you notice or have you been told that you either sigh a lot or do not sigh at all?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
39. Have you ever had problems with apnea or an apparent life threatening event?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
40. Have you ever been given a diagnosis of alveolar hypoventilation?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
41. Have you ever had problems with breath holding spells?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
42. Has there ever been a SIDS death in your family?
43. Has anyone in the family been on a home monitor? As an infant, child, or adult?
Sudomotor System Questions
Remember when you answer these questions we would like to know if you ever experienced these symptoms at any time - as an infant, child or adult. Also, tell me first about you and then about any of the people you told me about when we drew the family tree.
44. Have you ever had problems with difficulty sweating?
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
45. Have you ever had problems with body temperature?
Too hot/hyperpyrexia
Too cold/hypothermia
Age at onset of symptoms
When do symptoms occur
Associated with any other symptoms?
Last event
Did you seek medical attention for these events?
If yes, was a diagnosis made?
Additional Questions (Answer "yes" or "no):
Have any members of your family tree been diagnosed with the following:
- Obstructive sleep apnea
- Asthma
- Snoring
- Depression (any kind)
- Seizures
- Multiple Sclerosis
- Prematurity
- Down syndrome
- Ulcerative colitis
Crohn’s disease
Irritable bowel syndrome - Gastroesophageal reflux
- Stillbirths
- Issues related to menses
Genetic Testing:
Genetic testing (stepwise) is used to identify a CCHS-related PHOX2B mutation (required to confirm the diagnosis of CCHS). If Step 1 testing is negative, then Step 2 testing should be performed. If Step 2 testing is negative, then Step 3 testing should be performed. Normal PHOX2B genotype is 20/20 reflecting the number of alanines on each allele. Patients with CCHS are heterozygous for a disease-causing PHOX2B mutation. This testing should be done via a CLIA-certified laboratory. Information regarding these laboratories is located on www.genetests.org
- Step 1. PHOX2B Screening Test (also known as Fragment Analysis or Genotyping Analysis): identifies all polyalanine repeat expansion mutations (PARMs)(genotypes 20/24-20/33), the large frameshift non-PARMs (NPARMs), and somatic mosaicism. It is the only clinically available test that will identify low level somatic mosaicism.
- Step 2. PHOX2B Sequencing Test: identifies all known PARMs (genotypes 20/24-20/33) and all NPARMs. Does NOT identify low level somatic mosaicism.
- Step 3. PHOX2B MLPA Test: identifies whole gene or whole exon deletions and duplications.
Physiologic and other clinical testing:
Physiologic and other clinical testing that follows the 2010 ATS Statement on CCHS recommendations is optimal to diagnose and provide conservative management of affected patients, with aim for longitudinal follow-up and objective measures before and after pharmacological intervention.
- Detailed recording in a pediatric respiratory physiology laboratory for documentation of hypoventilation or absent spontaneous breathing asleep (most severe in non-REM sleep) and in varied activities of daily living while awake over the course of 4 days and 4 nights to adequately represent the patient’s needs. A subset of individuals with CCHS will hypoventilate awake and asleep. Testing should be completed during spontaneous breathing as well as with artificial ventilatory support.
- Tidal volume (pneumotachograph) measurement
- In CCHS below 7 cc/kg (usually below 5 cc/kg and lower asleep)
- Normal range in healthy controls is 7-10 cc/kg
- Movement (respiratory inductance plethysmography) of the chest and abdomen
- Respiratory frequency
- In CCHS, respiratory rates will typically be above norms for age.
- General ranges for healthy norms is provided below:
- Birth to 6 weeks: 30-60 breaths per minute (bpm)
- 6 months: 25-40 bpm
- 3 years: 20-30 bpm
- 6 years: 18-25 bpm
- 10 years: 12-15 bpm
- Adults: 12-20 bpm
- Hemoglobin saturation with visible pulse waveform and beat-to-beat measures
- In CCHS below 92% during sleep and, if awake hypoventilation, when awake
- End tidal carbon dioxide with visible breath-to-breath measures
- In CCHS above 50 mmHg during sleep, and if awake hypoventilation, when awake
- ECG
- In CCHS decreased heart rate variability and in a subset of cases sinus pauses
- If possible, measures of blood pressure and cerebral oxygenation/regional blood flow should be included
- Exogenous and endogenous ventilatory challenges in response to hypoxemia and hypercarbia (awake and asleep)
- In CCHS lack of a consistent or sustained normal ventilatory or cardiovascular response to clinical challenges with Hypercarbia (5%)/Hyperoxia (95%), Hypercarbia (7%)/Hypoxia (14%), and Hypoxia (5 breaths of nitrogen).
- 72-hour Holter recording annually to evaluate for cardiac sinus pauses
- Neurocognitive testing
- Evaluation for tumors of neural crest origin if PHOX2B genotype 20/28-20/33 or NPARM
- Evaluation for Hirschsprung disease
- Age and symptom-specific autonomic testing
- Birth through adult Poincaré plots of r-r +1 vs. r-r (cigar pattern in CCHS), pupillometry (typically decreased pupillary response to light but PHOX2B genotype-specific), and peripheral skin temperatures (typically mildly reduced)6 years through adult: head-up tilt (typically uncoupling of blood pressure and heart rate and altered cerebral regional blood flow), thermoregulatory sweat test (typically altered sweating pattern and reduced peripheral skin temperature), heart rate-deep breathing, Valsalva maneuver, and more depending on child’s symptoms and ability to cooperate.
Personnel and Training Required
The interviewer must be trained to conduct personal interviews with individuals from the general population. The interviewer must be trained and found to be competent (i.e., tested by an expert) at the completion of personal interviews. The interviewer should be trained to prompt respondents further if a "don’t know" response is provided.
Equipment Needs
PHOX2B genetic testing: Clinical Laboratory Improvement Amendments (CLIA)-certified laboratories listed at www.genetests.org.
Physiologic testing:
| NAME | FUNCTION |
| Audiovisual Systems | Audiovisual recording |
| Somnostar Data Acquisition System (Viasys) | Recording, therapist-assisted analysis, and reporting of physiological data, including tidal volume, inductance plethysmography of chest and abdomen, hemoglobin saturation (SpO2), end tidal carbon dioxide (ETCO2), ECG, blood pressure, and near-infrared spectroscopy reflecting cerebral oxygenation/regional blood flow (rSO2) during sleep and wakefulness (in varied activities of daily living asleep and awake, including head-up tilt) |
| Pneumotachograph (Korr Technologies) | Measures tidal volume |
| Oridion Capnostream 20 | Measures continuous beat-to-beat SpO2 and pulse waveform as well as breath-to-breath ETCO2 |
| Somanetics INVOS oximeter | Measures continuous regional cerebral blood flow/oxygenation (rSO2) by near-infrared spectroscopy (NIRS) |
| Neuroptics PLR 2000 Pupillometer | Measures pupillary response to fixed light stimulus with calculation of specific autonomic measures |
| Nexfin | Measures continuous beat-to-beat arterial blood pressure monitor (finger) |
| Welch Allyn Vital Signs Monitor 300 | Measures brachial blood pressure monitor (arm) |
| Thermoregulatory Sweat Chamber with infrared Camera | Qualitative sweat analysis for pre- and postganglionic sudomotor function as well as Thermalprint distribution with heat map |
| WR Medical Electronics System | Autonomic testing data system to evaluate heart rate deep breathing test, Valsalva maneuver, and QSweat test (postganglionic sudomotor function) |
| Peripheral Skin Temperature (Exergen) | Measures peripheral skin temperature |
Requirements
| Requirement Category | Required |
|---|---|
| Major equipment | No |
| Specialized training | No |
| Specialized requirements for biospecimen collection | No |
| Average time of greater than 15 minutes in an unaffected individual | Yes |
Mode of Administration
Self- or proxy-administered questionnaire
Lifestage
Infant, Toddler, Child, Adolescent, Adult, Senior, Pregnancy
Participants
Birth to adulthood
Selection Rationale
Collecting data on Congenital Central Hypoventilation Syndrome (CCHS) in a standard fashion is critical to understanding the condition throughout childhood and longitudinally throughout adulthood and for treatment of individuals with this condition.
The Rare Genetic Conditions Working Group (WG) recommends following the American Thoracic Society (ATS) policy statement regarding CCHS as a method for identifying appropriate participants for clinical research and epidemiological studies. The WG also notes that completion of the Autonomic Nervous System Questionnaire (ANSQ), step-wise PHOX2B genetic testing, and physiologic (and other clinical) testing is high burden but essential to fully characterize the CCHS phenotype and provide genetic confirmation of the diagnosis.
Language
English
Standards
| Standard | Name | ID | Source |
|---|---|---|---|
| Human Phenotype Ontology | Abnormal autonomic nervous system physiology | HP:0012332 | HPO |
| caDSR Form | PhenX PX220801 - Disorders Of Respiratory Control With Inherent Autonomic | 6187228 | caDSR Form |
Derived Variables
None
Process and Review
This section will be completed when reviewed by an Expert Review Panel.
Protocol Name from Source
Autonomic Nervous System Questionnaire (ANSQ) American Thoracic Society (ATS) Statement on CCHS (2010)
Source
Weese-Mayer, D. E., Berry-Kravis, E. M., Ceccherini, I., Keens, T. G., Loghmanee, D., & Trang, H; American Thoracic Society Congenital Central Hypoventilation Syndrome Subcommittee. (2010). An official American Thoracic Society clinical policy statement: Congenital central hypoventilation syndrome. Genetic basis, diagnosis, and management. American Journal of Respiratory and Critical Care Medicine, 181, 626-644.
Weese-Mayer, D. E., Patwari, P. P., Rand, C. M., Diedrich, A. M., Kuntz, N. L., & Berry-Kravis, E. M. (2012). Congenital Central Hypoventilation Syndrome (CCHS) and PHOX2B mutations. In D. Robertson, I. Biaggioni, G. Burnstock, P. A. Low, & J. F. R. Paton (Eds.), Primer on the autonomic nervous system (pp. pp. 445-450). Oxford: Academic Press.
Weese-Mayer, D. E., Silvestri, J. M., Huffman, A. D., Smok-Pearsall, S. M., Kowal, M. H., Maher, B. S., Cooper. M. E., & Marazita, M. L. (2001). Case/control family study of ANS dysfunction in idiopathic congenital central hypoventilation syndrome. American Journal of Medical Genetics, 100, 237-245.
General References
Carroll, M. S., Patwari, P. P., Kenny, A. S., Brogadir, C. D., Stewart, T. M., & Weese-Mayer, D. E. (2014). Residual chemosensory response to exogenous ventilatory challenges in paired-like homeobox 2B mutation-confirmed congenital central hypoventilation syndrome. Journal of Applied Physiology, 116, 439-450.
Gordon, S. C., Rand, C. M., & Weese-Mayer, D. E. (2013). Congenital central hypoventilation syndrome. In Rare Disease Database. Danbury, CT: National Organization for Rare Disorders. www.rarediseases.org.
Jennings, L. J., Yu, M., Rand, C. M., Kravis, N., Berry-Kravis, E. M., Patwari, P. P., & Weese-Mayer, D. E. (2012). Variable human phenotype associated with novel deletions of the PHOX2B gene. Pediatric Pulmonology, 47(2),153-161.
Jennings, L. J., Yu, M., Zhou, L., Rand, C. M., Berry-Kravis, E. M., & Weese-Mayer, D. E. (2010). Comparison of PHOX2B testing methods in the diagnosis of congenital central hypoventilation syndrome and mosaic carriers. Diagnostic Molecular Pathology, 19(4), 224-231.
Marazita, M. L., Maher, B. S., Cooper, M. E., Silvestri, J. M., Huffman, A. D., Smok-Pearsall, S. M., Kowal, M. H., & Weese-Mayer, D. E. (2001). Genetic segregation analysis of autonomic nervous system dysfunction in families of probands with congenital central hypoventilation syndrome. American Journal of Medical Genetics, 100, 229-236.
Patwari, P. P., Stewart, T. M., Rand, C. M., Carroll, M. S., Kuntz, N. L., Kenny, A. S., Brogadir, C. D., & Weese-Mayer, D. E. (2012). Pupillometry in Congenital Central Hypoventilation Syndrome (CCHS): Quantitative evidence of autonomic nervous system dysregulation. Pediatric Research, 71(3), 280-285.
Weese-Mayer, D. E., Marazita, M. L., Rand, C. M., & Berry-Kravis, E. M. (2004). Congenital central hypoventilation syndrome. In R. A. Pagon, M. P. Adam, T. D. Bird, et al. (Eds.), GeneReviews™ [Internet]. Seattle, WA: University of Washington. www.ncbi.nlm.nih.gov/books/NBK1427/.
Protocol ID
220801
Variables
Export Variables| Variable Name | Variable ID | Variable Description | dbGaP Mapping | |
|---|---|---|---|---|
| PX220801_CCHS_ANSQ_Family_Atypical_Growth | ||||
| PX220801030000 | Autonomic Nervous System Questionnaire more | N/A | ||
| PX220801_CCHS_ANSQ_Family_Genetic_Disease | ||||
| PX220801080000 | Autonomic Nervous System Questionnaire more | N/A | ||
| PX220801_CCHS_ANSQ_Family_Growth_Hormone_Problem | ||||
| PX220801050000 | Autonomic Nervous System Questionnaire more | N/A | ||
| PX220801_CCHS_ANSQ_Family_Height | ||||
| PX220801010000 | Autonomic Nervous System Questionnaire more | N/A | ||
| PX220801_CCHS_ANSQ_Family_Obesity_Diagnosis | ||||
| PX220801040000 | Autonomic Nervous System Questionnaire more | N/A | ||
| PX220801_CCHS_ANSQ_Family_Other_Problem | ||||
| PX220801110000 | Autonomic Nervous System Questionnaire more | N/A | ||
| PX220801_CCHS_ANSQ_Family_Parkinson_Disease | ||||
| PX220801090000 | Autonomic Nervous System Questionnaire more | N/A | ||
| PX220801_CCHS_ANSQ_Family_Significant_Medical_Problem | ||||
| PX220801060000 | Autonomic Nervous System Questionnaire more | N/A | ||
| PX220801_CCHS_ANSQ_Family_Strabismus | ||||
| PX220801100000 | Autonomic Nervous System Questionnaire more | N/A | ||
| PX220801_CCHS_ANSQ_Family_Unusual_Skin_Pigmentation | ||||
| PX220801070000 | Autonomic Nervous System Questionnaire more | N/A | ||
| PX220801_CCHS_ANSQ_Family_Weight | ||||
| PX220801020000 | Autonomic Nervous System Questionnaire more | N/A | ||
| PX220801_CCHS_AQ_Family_Diagnosis_Asthma | ||||
| PX220801600100 | Additional Questions - Have any members of more | Variable Mapping | ||
| PX220801_CCHS_AQ_Family_Diagnosis_Depression | ||||
| PX220801620100 | Additional Questions - Have any members of more | Variable Mapping | ||
| PX220801_CCHS_AQ_Family_Diagnosis_Down_Syndrome | ||||
| PX220801660100 | Additional Questions - Have any members of more | N/A | ||
| PX220801_CCHS_AQ_Family_Diagnosis_Gastroesophageal_Reflux | ||||
| PX220801680100 | Additional Questions - Have any members of more | N/A | ||
| PX220801_CCHS_AQ_Family_Diagnosis_Menses | ||||
| PX220801700100 | Additional Questions - Have any members of more | N/A | ||
| PX220801_CCHS_AQ_Family_Diagnosis_Multiple_Sclerosis | ||||
| PX220801640100 | Additional Questions - Have any members of more | Variable Mapping | ||
| PX220801_CCHS_AQ_Family_Diagnosis_Obstructive_Sleep_Apnea | ||||
| PX220801590100 | Additional Questions - Have any members of more | N/A | ||
| PX220801_CCHS_AQ_Family_Diagnosis_Prematurity | ||||
| PX220801650100 | Additional Questions - Have any members of more | Variable Mapping | ||
| PX220801_CCHS_AQ_Family_Diagnosis_Seizure | ||||
| PX220801630100 | Additional Questions - Have any members of more | N/A | ||
| PX220801_CCHS_AQ_Family_Diagnosis_Snoring | ||||
| PX220801610100 | Additional Questions - Have any members of more | N/A | ||
| PX220801_CCHS_AQ_Family_Diagnosis_Stillbirths | ||||
| PX220801690100 | Additional Questions - Have any members of more | N/A | ||
| PX220801_CCHS_AQ_Family_Diagnosis_Ulcerative_Colitis | ||||
| PX220801670100 | Additional Questions - Have any members of more | Variable Mapping | ||
| PX220801_CCHS_CSQ_Blurred_Vision | ||||
| PX220801130100 | Cardiovascular System Questions - Have you more | N/A | ||
| PX220801_CCHS_CSQ_Blurred_Vision_Age | ||||
| PX220801130300 | Cardiovascular System Questions - Age at more | N/A | ||
| PX220801_CCHS_CSQ_Blurred_Vision_Associated_Factor | ||||
| PX220801130500 | Cardiovascular System Questions - Is the more | N/A | ||
| PX220801_CCHS_CSQ_Blurred_Vision_Diagnosis | ||||
| PX220801130900 | Cardiovascular System Questions - If yes, more | N/A | ||
| PX220801_CCHS_CSQ_Blurred_Vision_Frequency | ||||
| PX220801130600 | Cardiovascular System Questions - How often: | N/A | ||
| PX220801_CCHS_CSQ_Blurred_Vision_Last_Event | ||||
| PX220801130700 | Cardiovascular System Questions - Last event | N/A | ||
| PX220801_CCHS_CSQ_Blurred_Vision_Medical_Attention | ||||
| PX220801130800 | Cardiovascular System Questions - Did you more | N/A | ||
| PX220801_CCHS_CSQ_Blurred_Vision_Severity | ||||
| PX220801130200 | Cardiovascular System Questions - How severe more | N/A | ||
| PX220801_CCHS_CSQ_Blurred_Vision_Time | ||||
| PX220801130400 | Cardiovascular System Questions - When do more | N/A | ||
| PX220801_CCHS_CSQ_Cold_Finger_Toe | ||||
| PX220801170100 | Cardiovascular System Questions - Have you more | N/A | ||
| PX220801_CCHS_CSQ_Cold_Finger_Toe_Age | ||||
| PX220801170300 | Cardiovascular System Questions - Age at more | N/A | ||
| PX220801_CCHS_CSQ_Cold_Finger_Toe_Associated_Factor | ||||
| PX220801170500 | Cardiovascular System Questions - Associated more | N/A | ||
| PX220801_CCHS_CSQ_Cold_Finger_Toe_Diagnosis | ||||
| PX220801170900 | Cardiovascular System Questions - If yes, more | N/A | ||
| PX220801_CCHS_CSQ_Cold_Finger_Toe_Frequency | ||||
| PX220801170600 | Cardiovascular System Questions - How often: | N/A | ||
| PX220801_CCHS_CSQ_Cold_Finger_Toe_Last_Event | ||||
| PX220801170700 | Cardiovascular System Questions - Last event | N/A | ||
| PX220801_CCHS_CSQ_Cold_Finger_Toe_Medical_Attention | ||||
| PX220801170800 | Cardiovascular System Questions - Did you more | N/A | ||
| PX220801_CCHS_CSQ_Cold_Finger_Toe_Severity | ||||
| PX220801170200 | Cardiovascular System Questions - How severe more | N/A | ||
| PX220801_CCHS_CSQ_Cold_Finger_Toe_Time | ||||
| PX220801170400 | Cardiovascular System Questions - When do more | N/A | ||
| PX220801_CCHS_CSQ_Dizziness | ||||
| PX220801120100 | Cardiovascular System Questions - Have you more | Variable Mapping | ||
| PX220801_CCHS_CSQ_Dizziness_Age | ||||
| PX220801120400 | Cardiovascular System Questions - Age at more | N/A | ||
| PX220801_CCHS_CSQ_Dizziness_Aggravating_Factor | ||||
| PX220801120600 | Cardiovascular System Questions - Are there more | N/A | ||
| PX220801_CCHS_CSQ_Dizziness_Associated_Event | ||||
| PX220801120700 | Cardiovascular System Questions - Is the more | N/A | ||
| PX220801_CCHS_CSQ_Dizziness_Diagnosis | ||||
| PX220801121000 | Cardiovascular System Questions - If yes, more | N/A | ||
| PX220801_CCHS_CSQ_Dizziness_Frequency | ||||
| PX220801120300 | Cardiovascular System Questions - How often: | Variable Mapping | ||
| PX220801_CCHS_CSQ_Dizziness_Last_Event | ||||
| PX220801120800 | Cardiovascular System Questions - Last event | Variable Mapping | ||
| PX220801_CCHS_CSQ_Dizziness_Medical_Attention | ||||
| PX220801120900 | Cardiovascular System Questions - Did you more | N/A | ||
| PX220801_CCHS_CSQ_Dizziness_Severity | ||||
| PX220801120200 | Cardiovascular System Questions - How severe more | N/A | ||
| PX220801_CCHS_CSQ_Dizziness_Time | ||||
| PX220801120500 | Cardiovascular System Questions - When do more | N/A | ||
| PX220801_CCHS_CSQ_Doctor_Diagnosis | ||||
| PX220801190000 | Cardiovascular System Questions - Have you more | N/A | ||
| PX220801_CCHS_CSQ_Facial_Pallor | ||||
| PX220801160100 | Cardiovascular System Questions - Have you more | N/A | ||
| PX220801_CCHS_CSQ_Facial_Pallor_Age | ||||
| PX220801160300 | Cardiovascular System Questions - Age at more | N/A | ||
| PX220801_CCHS_CSQ_Facial_Pallor_Associated_Factor | ||||
| PX220801160500 | Cardiovascular System Questions - Associated more | N/A | ||
| PX220801_CCHS_CSQ_Facial_Pallor_Diagnosis | ||||
| PX220801160900 | Cardiovascular System Questions - If yes, more | N/A | ||
| PX220801_CCHS_CSQ_Facial_Pallor_Frequency | ||||
| PX220801160600 | Cardiovascular System Questions - How often: | N/A | ||
| PX220801_CCHS_CSQ_Facial_Pallor_Last_Event | ||||
| PX220801160700 | Cardiovascular System Questions - Last event | N/A | ||
| PX220801_CCHS_CSQ_Facial_Pallor_Medical_Attention | ||||
| PX220801160800 | Cardiovascular System Questions - Did you more | N/A | ||
| PX220801_CCHS_CSQ_Facial_Pallor_Severity | ||||
| PX220801160200 | Cardiovascular System Questions - How severe more | N/A | ||
| PX220801_CCHS_CSQ_Facial_Pallor_Time | ||||
| PX220801160400 | Cardiovascular System Questions - When do more | N/A | ||
| PX220801_CCHS_CSQ_Headache | ||||
| PX220801150100 | Cardiovascular System Questions - Have you more | N/A | ||
| PX220801_CCHS_CSQ_Headache_Age | ||||
| PX220801150400 | Cardiovascular System Questions - Age at more | N/A | ||
| PX220801_CCHS_CSQ_Headache_Associated_Factor | ||||
| PX220801150300 | Cardiovascular System Questions - Is the more | N/A | ||
| PX220801_CCHS_CSQ_Headache_Associated_Other | ||||
| PX220801150600 | Cardiovascular System Questions - Associated more | N/A | ||
| PX220801_CCHS_CSQ_Headache_Diagnosis | ||||
| PX220801151000 | Cardiovascular System Questions - If yes, more | N/A | ||
| PX220801_CCHS_CSQ_Headache_Frequency | ||||
| PX220801150700 | Cardiovascular System Questions - How often: | N/A | ||
| PX220801_CCHS_CSQ_Headache_Last_Event | ||||
| PX220801150800 | Cardiovascular System Questions - Last event | N/A | ||
| PX220801_CCHS_CSQ_Headache_Medical_Attention | ||||
| PX220801150900 | Cardiovascular System Questions - Did you more | N/A | ||
| PX220801_CCHS_CSQ_Headache_Severity | ||||
| PX220801150200 | Cardiovascular System Questions - How severe more | N/A | ||
| PX220801_CCHS_CSQ_Headache_Time | ||||
| PX220801150500 | Cardiovascular System Questions - When do more | N/A | ||
| PX220801_CCHS_CSQ_Loss_Consciousness | ||||
| PX220801140100 | Cardiovascular System Questions - Have you more | Variable Mapping | ||
| PX220801_CCHS_CSQ_Loss_Consciousness_Age | ||||
| PX220801140300 | Cardiovascular System Questions - Age at more | N/A | ||
| PX220801_CCHS_CSQ_Loss_Consciousness_Associated_Factor | ||||
| PX220801140500 | Cardiovascular System Questions - Is the more | N/A | ||
| PX220801_CCHS_CSQ_Loss_Consciousness_Diagnosis | ||||
| PX220801140900 | Cardiovascular System Questions - If yes, more | N/A | ||
| PX220801_CCHS_CSQ_Loss_Consciousness_Frequency | ||||
| PX220801140600 | Cardiovascular System Questions - How often: | N/A | ||
| PX220801_CCHS_CSQ_Loss_Consciousness_Last_Event | ||||
| PX220801140700 | Cardiovascular System Questions - Last event | N/A | ||
| PX220801_CCHS_CSQ_Loss_Consciousness_Medical_Attention | ||||
| PX220801140800 | Cardiovascular System Questions - Did you more | Variable Mapping | ||
| PX220801_CCHS_CSQ_Loss_Consciousness_Severity | ||||
| PX220801140200 | Cardiovascular System Questions - How severe more | N/A | ||
| PX220801_CCHS_CSQ_Loss_Consciousness_Time | ||||
| PX220801140400 | Cardiovascular System Questions - When do more | N/A | ||
| PX220801_CCHS_CSQ_Raynaud_Phenomenon | ||||
| PX220801180100 | Cardiovascular System Questions - Have you more | N/A | ||
| PX220801_CCHS_CSQ_Raynaud_Phenomenon_Age | ||||
| PX220801180300 | Cardiovascular System Questions - Age at more | Variable Mapping | ||
| PX220801_CCHS_CSQ_Raynaud_Phenomenon_Associated_Factor | ||||
| PX220801180500 | Cardiovascular System Questions - Associated more | N/A | ||
| PX220801_CCHS_CSQ_Raynaud_Phenomenon_Diagnosis | ||||
| PX220801180900 | Cardiovascular System Questions - If yes, more | N/A | ||
| PX220801_CCHS_CSQ_Raynaud_Phenomenon_Frequency | ||||
| PX220801180600 | Cardiovascular System Questions - How often: | N/A | ||
| PX220801_CCHS_CSQ_Raynaud_Phenomenon_Last_Event | ||||
| PX220801180700 | Cardiovascular System Questions - Last event | Variable Mapping | ||
| PX220801_CCHS_CSQ_Raynaud_Phenomenon_Medical_Attention | ||||
| PX220801180800 | Cardiovascular System Questions - Did you more | N/A | ||
| PX220801_CCHS_CSQ_Raynaud_Phenomenon_Severity | ||||
| PX220801180200 | Cardiovascular System Questions - How severe more | N/A | ||
| PX220801_CCHS_CSQ_Raynaud_Phenomenon_Time | ||||
| PX220801180400 | Cardiovascular System Questions - When do more | N/A | ||
| PX220801_CCHS_GSQ_Abdominal_Pain | ||||
| PX220801310100 | Gastrointestinal System Questions - Have you more | N/A | ||
| PX220801_CCHS_GSQ_Abdominal_Pain_Age | ||||
| PX220801310300 | Gastrointestinal System Questions - Age at more | N/A | ||
| PX220801_CCHS_GSQ_Abdominal_Pain_Associated_Factor | ||||
| PX220801310500 | Gastrointestinal System Questions - more | N/A | ||
| PX220801_CCHS_GSQ_Abdominal_Pain_Diagnosis | ||||
| PX220801310900 | Gastrointestinal System Questions - If yes, more | N/A | ||
| PX220801_CCHS_GSQ_Abdominal_Pain_Frequency | ||||
| PX220801310600 | Gastrointestinal System Questions - How often: | Variable Mapping | ||
| PX220801_CCHS_GSQ_Abdominal_Pain_Last_Event | ||||
| PX220801310700 | Gastrointestinal System Questions - Last event | N/A | ||
| PX220801_CCHS_GSQ_Abdominal_Pain_Medical_Attention | ||||
| PX220801310800 | Gastrointestinal System Questions - Did you more | N/A | ||
| PX220801_CCHS_GSQ_Abdominal_Pain_Severity | ||||
| PX220801310200 | Gastrointestinal System Questions - How more | N/A | ||
| PX220801_CCHS_GSQ_Abdominal_Pain_Time | ||||
| PX220801310400 | Gastrointestinal System Questions - When do more | N/A | ||
| PX220801_CCHS_GSQ_Abdominal_Surgery | ||||
| PX220801270100 | Gastrointestinal System Questions - Have you more | N/A | ||
| PX220801_CCHS_GSQ_Abdominal_Surgery_Date | ||||
| PX220801270300 | Gastrointestinal System Questions - date of more | N/A | ||
| PX220801_CCHS_GSQ_Abdominal_Surgery_Reason | ||||
| PX220801270400 | Gastrointestinal System Questions - reason more | N/A | ||
| PX220801_CCHS_GSQ_Abdominal_Surgery_Scar | ||||
| PX220801270200 | Gastrointestinal System Questions - Have you more | N/A | ||
| PX220801_CCHS_GSQ_Anorexia | ||||
| PX220801220100 | Gastrointestinal System Questions - Have you more | Variable Mapping | ||
| PX220801_CCHS_GSQ_Anorexia_Age | ||||
| PX220801220300 | Gastrointestinal System Questions - Age at more | Variable Mapping | ||
| PX220801_CCHS_GSQ_Anorexia_Associated_Factor | ||||
| PX220801220500 | Gastrointestinal System Questions - more | N/A | ||
| PX220801_CCHS_GSQ_Anorexia_Diagnosis | ||||
| PX220801220900 | Gastrointestinal System Questions - If yes, more | Variable Mapping | ||
| PX220801_CCHS_GSQ_Anorexia_Frequency | ||||
| PX220801220600 | Gastrointestinal System Questions - How often: | N/A | ||
| PX220801_CCHS_GSQ_Anorexia_Last_Event | ||||
| PX220801220700 | Gastrointestinal System Questions - Last event | N/A | ||
| PX220801_CCHS_GSQ_Anorexia_Medical_Attention | ||||
| PX220801220800 | Gastrointestinal System Questions - Did you more | N/A | ||
| PX220801_CCHS_GSQ_Anorexia_Severity | ||||
| PX220801220200 | Gastrointestinal System Questions - How more | N/A | ||
| PX220801_CCHS_GSQ_Anorexia_Time | ||||
| PX220801220400 | Gastrointestinal System Questions - When do more | N/A | ||
| PX220801_CCHS_GSQ_Autonomic_Diarrhea | ||||
| PX220801300100 | Gastrointestinal System Questions - Have you more | N/A | ||
| PX220801_CCHS_GSQ_Autonomic_Diarrhea_Age | ||||
| PX220801300300 | Gastrointestinal System Questions - Age at more | N/A | ||
| PX220801_CCHS_GSQ_Autonomic_Diarrhea_Associated_Factor | ||||
| PX220801300500 | Gastrointestinal System Questions - more | N/A | ||
| PX220801_CCHS_GSQ_Autonomic_Diarrhea_Diagnosis | ||||
| PX220801300900 | Gastrointestinal System Questions - If yes, more | N/A | ||
| PX220801_CCHS_GSQ_Autonomic_Diarrhea_Frequency | ||||
| PX220801300600 | Gastrointestinal System Questions - How often: | Variable Mapping | ||
| PX220801_CCHS_GSQ_Autonomic_Diarrhea_Last_Event | ||||
| PX220801300700 | Gastrointestinal System Questions - Last event | Variable Mapping | ||
| PX220801_CCHS_GSQ_Autonomic_Diarrhea_Medical_Attention | ||||
| PX220801300800 | Gastrointestinal System Questions - Did you more | N/A | ||
| PX220801_CCHS_GSQ_Autonomic_Diarrhea_Severity | ||||
| PX220801300200 | Gastrointestinal System Questions - How more | N/A | ||
| PX220801_CCHS_GSQ_Autonomic_Diarrhea_Time | ||||
| PX220801300400 | Gastrointestinal System Questions - When do more | N/A | ||
| PX220801_CCHS_GSQ_Bloating | ||||
| PX220801240100 | Gastrointestinal System Questions - Have you more | N/A | ||
| PX220801_CCHS_GSQ_Bloating_Age | ||||
| PX220801240300 | Gastrointestinal System Questions - Age at more | N/A | ||
| PX220801_CCHS_GSQ_Bloating_Associated_Factor | ||||
| PX220801240500 | Gastrointestinal System Questions - more | N/A | ||
| PX220801_CCHS_GSQ_Bloating_Diagnosis | ||||
| PX220801240900 | Gastrointestinal System Questions - If yes, more | N/A | ||
| PX220801_CCHS_GSQ_Bloating_Frequency | ||||
| PX220801240600 | Gastrointestinal System Questions - How often: | N/A | ||
| PX220801_CCHS_GSQ_Bloating_Last_Event | ||||
| PX220801240700 | Gastrointestinal System Questions - Last event | N/A | ||
| PX220801_CCHS_GSQ_Bloating_Medical_Attention | ||||
| PX220801240800 | Gastrointestinal System Questions - Did you more | N/A | ||
| PX220801_CCHS_GSQ_Bloating_Severity | ||||
| PX220801240200 | Gastrointestinal System Questions - How more | N/A | ||
| PX220801_CCHS_GSQ_Bloating_Time | ||||
| PX220801240400 | Gastrointestinal System Questions - When do more | N/A | ||
| PX220801_CCHS_GSQ_Dysphagia_Difficulty_Swallowing | ||||
| PX220801210100 | Gastrointestinal System Questions - Have you more | Variable Mapping | ||
| PX220801_CCHS_GSQ_Dysphagia_Difficulty_Swallowing_Age | ||||
| PX220801210300 | Gastrointestinal System Questions - Age at more | N/A | ||
| PX220801_CCHS_GSQ_Dysphagia_Difficulty_Swallowing_Associated_Factor | ||||
| PX220801210500 | Gastrointestinal System Questions - more | N/A | ||
| PX220801_CCHS_GSQ_Dysphagia_Difficulty_Swallowing_Diagnosis | ||||
| PX220801210900 | Gastrointestinal System Questions - If yes, more | N/A | ||
| PX220801_CCHS_GSQ_Dysphagia_Difficulty_Swallowing_Frequency | ||||
| PX220801210600 | Gastrointestinal System Questions - How often: | N/A | ||
| PX220801_CCHS_GSQ_Dysphagia_Difficulty_Swallowing_Last_Event | ||||
| PX220801210700 | Gastrointestinal System Questions - Last event | N/A | ||
| PX220801_CCHS_GSQ_Dysphagia_Difficulty_Swallowing_Medical_Attention | ||||
| PX220801210801 | Gastrointestinal System Questions - Did you more | N/A | ||
| PX220801_CCHS_GSQ_Dysphagia_Difficulty_Swallowing_Severity | ||||
| PX220801210200 | Gastrointestinal System Questions - How more | N/A | ||
| PX220801_CCHS_GSQ_Dysphagia_Difficulty_Swallowing_Time | ||||
| PX220801210400 | Gastrointestinal System Questions - When do more | N/A | ||
| PX220801_CCHS_GSQ_Early_Satiety | ||||
| PX220801230100 | Gastrointestinal System Questions - Have you more | N/A | ||
| PX220801_CCHS_GSQ_Early_Satiety_Age | ||||
| PX220801230300 | Gastrointestinal System Questions - Age at more | N/A | ||
| PX220801_CCHS_GSQ_Early_Satiety_Associated_Factor | ||||
| PX220801230500 | Gastrointestinal System Questions - more | N/A | ||
| PX220801_CCHS_GSQ_Early_Satiety_Diagnosis | ||||
| PX220801230900 | Gastrointestinal System Questions - If yes, more | N/A | ||
| PX220801_CCHS_GSQ_Early_Satiety_Frequency | ||||
| PX220801230600 | Gastrointestinal System Questions - How often: | N/A | ||
| PX220801_CCHS_GSQ_Early_Satiety_Last_Event | ||||
| PX220801230700 | Gastrointestinal System Questions - Last event | N/A | ||
| PX220801_CCHS_GSQ_Early_Satiety_Medical_Attention | ||||
| PX220801230800 | Gastrointestinal System Questions - Did you more | N/A | ||
| PX220801_CCHS_GSQ_Early_Satiety_Severity | ||||
| PX220801230200 | Gastrointestinal System Questions - How more | N/A | ||
| PX220801_CCHS_GSQ_Early_Satiety_Time | ||||
| PX220801230400 | Gastrointestinal System Questions - When do more | N/A | ||
| PX220801_CCHS_GSQ_Frequent_Nausea | ||||
| PX220801250100 | Gastrointestinal System Questions - Have you more | N/A | ||
| PX220801_CCHS_GSQ_Frequent_Nausea_Age | ||||
| PX220801250300 | Gastrointestinal System Questions - Age at more | N/A | ||
| PX220801_CCHS_GSQ_Frequent_Nausea_Associated_Factor | ||||
| PX220801250500 | Gastrointestinal System Questions - more | N/A | ||
| PX220801_CCHS_GSQ_Frequent_Nausea_Diagnosis | ||||
| PX220801250900 | Gastrointestinal System Questions - If yes, more | N/A | ||
| PX220801_CCHS_GSQ_Frequent_Nausea_Frequency | ||||
| PX220801250600 | Gastrointestinal System Questions - How often: | N/A | ||
| PX220801_CCHS_GSQ_Frequent_Nausea_Last_Event | ||||
| PX220801250700 | Gastrointestinal System Questions - Last event | N/A | ||
| PX220801_CCHS_GSQ_Frequent_Nausea_Medical_Attention | ||||
| PX220801250800 | Gastrointestinal System Questions - Did you more | N/A | ||
| PX220801_CCHS_GSQ_Frequent_Nausea_Severity | ||||
| PX220801250200 | Gastrointestinal System Questions - How more | N/A | ||
| PX220801_CCHS_GSQ_Frequent_Nausea_Time | ||||
| PX220801250400 | Gastrointestinal System Questions - When do more | N/A | ||
| PX220801_CCHS_GSQ_Hirschsprung_Disease_Diagnosis | ||||
| PX220801280100 | Gastrointestinal System Questions - Have you more | N/A | ||
| PX220801_CCHS_GSQ_Profuse_Oral_Secretion | ||||
| PX220801200100 | Gastrointestinal System Questions - Have you more | N/A | ||
| PX220801_CCHS_GSQ_Profuse_Oral_Secretion_Age | ||||
| PX220801200300 | Gastrointestinal System Questions - Age at more | N/A | ||
| PX220801_CCHS_GSQ_Profuse_Oral_Secretion_Associated_Factor | ||||
| PX220801200500 | Gastrointestinal System Questions - more | N/A | ||
| PX220801_CCHS_GSQ_Profuse_Oral_Secretion_Diagnosis | ||||
| PX220801210802 | Gastrointestinal System Questions - If yes, more | N/A | ||
| PX220801_CCHS_GSQ_Profuse_Oral_Secretion_Frequency | ||||
| PX220801200600 | Gastrointestinal System Questions - How often: | N/A | ||
| PX220801_CCHS_GSQ_Profuse_Oral_Secretion_Last_Event | ||||
| PX220801200700 | Gastrointestinal System Questions - Last event | N/A | ||
| PX220801_CCHS_GSQ_Profuse_Oral_Secretion_Medical_Attention | ||||
| PX220801200800 | Gastrointestinal System Questions - Did you more | N/A | ||
| PX220801_CCHS_GSQ_Profuse_Oral_Secretion_Severity | ||||
| PX220801200200 | Gastrointestinal System Questions - How more | N/A | ||
| PX220801_CCHS_GSQ_Profuse_Oral_Secretion_Time | ||||
| PX220801200400 | Gastrointestinal System Questions - When do more | N/A | ||
| PX220801_CCHS_GSQ_Recurrent_Vomiting | ||||
| PX220801260100 | Gastrointestinal System Questions - Have you more | N/A | ||
| PX220801_CCHS_GSQ_Recurrent_Vomiting_Age | ||||
| PX220801260300 | Gastrointestinal System Questions - Age at more | N/A | ||
| PX220801_CCHS_GSQ_Recurrent_Vomiting_Associated_Factor | ||||
| PX220801260500 | Gastrointestinal System Questions - more | N/A | ||
| PX220801_CCHS_GSQ_Recurrent_Vomiting_Diagnosis | ||||
| PX220801260900 | Gastrointestinal System Questions - If yes, more | N/A | ||
| PX220801_CCHS_GSQ_Recurrent_Vomiting_Frequency | ||||
| PX220801260600 | Gastrointestinal System Questions - How often: | N/A | ||
| PX220801_CCHS_GSQ_Recurrent_Vomiting_Last_Event | ||||
| PX220801260700 | Gastrointestinal System Questions - Last event | N/A | ||
| PX220801_CCHS_GSQ_Recurrent_Vomiting_Medical_Attention | ||||
| PX220801260800 | Gastrointestinal System Questions - Did you more | N/A | ||
| PX220801_CCHS_GSQ_Recurrent_Vomiting_Severity | ||||
| PX220801260200 | Gastrointestinal System Questions - How more | N/A | ||
| PX220801_CCHS_GSQ_Recurrent_Vomiting_Time | ||||
| PX220801260400 | Gastrointestinal System Questions - When do more | N/A | ||
| PX220801_CCHS_GSQ_Severe_Constipation | ||||
| PX220801290100 | Gastrointestinal System Questions - Have you more | N/A | ||
| PX220801_CCHS_GSQ_Severe_Constipation_Age | ||||
| PX220801290300 | Gastrointestinal System Questions - Age at more | N/A | ||
| PX220801_CCHS_GSQ_Severe_Constipation_Associated_Factor | ||||
| PX220801290500 | Gastrointestinal System Questions - more | N/A | ||
| PX220801_CCHS_GSQ_Severe_Constipation_Diagnosis | ||||
| PX220801290900 | Gastrointestinal System Questions - If yes, more | N/A | ||
| PX220801_CCHS_GSQ_Severe_Constipation_Frequency | ||||
| PX220801290600 | Gastrointestinal System Questions - How often: | Variable Mapping | ||
| PX220801_CCHS_GSQ_Severe_Constipation_Last_Event | ||||
| PX220801290700 | Gastrointestinal System Questions - Last event | N/A | ||
| PX220801_CCHS_GSQ_Severe_Constipation_Medical_Attention | ||||
| PX220801290800 | Gastrointestinal System Questions - Did you more | N/A | ||
| PX220801_CCHS_GSQ_Severe_Constipation_Severity | ||||
| PX220801290200 | Gastrointestinal System Questions - How more | Variable Mapping | ||
| PX220801_CCHS_GSQ_Severe_Constipation_Time | ||||
| PX220801290400 | Gastrointestinal System Questions - When do more | N/A | ||
| PX220801_CCHS_GT_PHOX2B_MLPA_Test | ||||
| PX220801730100 | Genetic Testing - PHOX2B MLPA Test | N/A | ||
| PX220801_CCHS_GT_PHOX2B_Screening_Test | ||||
| PX220801710100 | Genetic Testing - PHOX2B Screening Test | N/A | ||
| PX220801_CCHS_GT_PHOX2B_Sequencing_Test | ||||
| PX220801720100 | Genetic Testing - PHOX2B Sequencing Test | N/A | ||
| PX220801_CCHS_NSQ_Altered_Pain_Perception | ||||
| PX220801340200 | Neurologic System Questions - Have you ever more | N/A | ||
| PX220801_CCHS_NSQ_Altered_Pain_Perception_Age | ||||
| PX220801340400 | Neurologic System Questions - Age at onset more | N/A | ||
| PX220801_CCHS_NSQ_Altered_Pain_Perception_Associated_Factor | ||||
| PX220801340600 | Neurologic System Questions - Associated more | N/A | ||
| PX220801_CCHS_NSQ_Altered_Pain_Perception_Diagnosis | ||||
| PX220801341000 | Neurologic System Questions - If yes, was a more | N/A | ||
| PX220801_CCHS_NSQ_Altered_Pain_Perception_Frequency | ||||
| PX220801340700 | Neurologic System Questions - How often: | N/A | ||
| PX220801_CCHS_NSQ_Altered_Pain_Perception_Last_Event | ||||
| PX220801340800 | Neurologic System Questions - Last event | N/A | ||
| PX220801_CCHS_NSQ_Altered_Pain_Perception_Medical_Attention | ||||
| PX220801340900 | Neurologic System Questions - Did you seek more | N/A | ||
| PX220801_CCHS_NSQ_Altered_Pain_Perception_Severity | ||||
| PX220801340300 | Neurologic System Questions - How severe is more | N/A | ||
| PX220801_CCHS_NSQ_Altered_Pain_Perception_Time | ||||
| PX220801340500 | Neurologic System Questions - When do more | N/A | ||
| PX220801_CCHS_NSQ_Decreased_Limb_Muscle_Tone | ||||
| PX220801330101 | Neurologic System Questions - Have you ever more | N/A | ||
| PX220801_CCHS_NSQ_Decreased_Limb_Muscle_Tone_Age | ||||
| PX220801330301 | Neurologic System Questions - Age at onset more | N/A | ||
| PX220801_CCHS_NSQ_Decreased_Limb_Muscle_Tone_Associated_Factor | ||||
| PX220801330501 | Neurologic System Questions - Associated more | N/A | ||
| PX220801_CCHS_NSQ_Decreased_Limb_Muscle_Tone_Diagnosis | ||||
| PX220801330901 | Neurologic System Questions - If yes, was a more | N/A | ||
| PX220801_CCHS_NSQ_Decreased_Limb_Muscle_Tone_Frequency | ||||
| PX220801330601 | Neurologic System Questions - How often: | N/A | ||
| PX220801_CCHS_NSQ_Decreased_Limb_Muscle_Tone_Last_Event | ||||
| PX220801330701 | Neurologic System Questions - Last event | N/A | ||
| PX220801_CCHS_NSQ_Decreased_Limb_Muscle_Tone_Medical_Attention | ||||
| PX220801330801 | Neurologic System Questions - Did you seek more | N/A | ||
| PX220801_CCHS_NSQ_Decreased_Limb_Muscle_Tone_Severity | ||||
| PX220801330201 | Neurologic System Questions - How severe is more | N/A | ||
| PX220801_CCHS_NSQ_Decreased_Limb_Muscle_Tone_Time | ||||
| PX220801330401 | Neurologic System Questions - When do more | N/A | ||
| PX220801_CCHS_NSQ_Migraine | ||||
| PX220801320100 | Neurologic System Questions - Have you ever more | Variable Mapping | ||
| PX220801_CCHS_NSQ_Migraine_Age | ||||
| PX220801320300 | Neurologic System Questions - Age at onset more | N/A | ||
| PX220801_CCHS_NSQ_Migraine_Associated_Factor | ||||
| PX220801320500 | Neurologic System Questions - Is the more | N/A | ||
| PX220801_CCHS_NSQ_Migraine_Diagnosis | ||||
| PX220801320900 | Neurologic System Questions - If yes, was a more | N/A | ||
| PX220801_CCHS_NSQ_Migraine_Frequency | ||||
| PX220801320600 | Neurologic System Questions - How often: | N/A | ||
| PX220801_CCHS_NSQ_Migraine_Last_Event | ||||
| PX220801320700 | Neurologic System Questions - Last event | N/A | ||
| PX220801_CCHS_NSQ_Migraine_Medical_Attention | ||||
| PX220801320800 | Neurologic System Questions - Did you seek more | N/A | ||
| PX220801_CCHS_NSQ_Migraine_Severity | ||||
| PX220801320200 | Neurologic System Questions - How severe is more | N/A | ||
| PX220801_CCHS_NSQ_Migraine_Time | ||||
| PX220801320400 | Neurologic System Questions - When do more | N/A | ||
| PX220801_CCHS_NSQ_Severe_Burning_Pain | ||||
| PX220801330102 | Neurologic System Questions - Have you ever more | N/A | ||
| PX220801_CCHS_NSQ_Severe_Burning_Pain_Age | ||||
| PX220801330302 | Neurologic System Questions - Age at onset more | N/A | ||
| PX220801_CCHS_NSQ_Severe_Burning_Pain_Associated_Factor | ||||
| PX220801330502 | Neurologic System Questions - Associated more | N/A | ||
| PX220801_CCHS_NSQ_Severe_Burning_Pain_Diagnosis | ||||
| PX220801330902 | Neurologic System Questions - If yes, was a more | N/A | ||
| PX220801_CCHS_NSQ_Severe_Burning_Pain_Frequency | ||||
| PX220801330602 | Neurologic System Questions - How often: | N/A | ||
| PX220801_CCHS_NSQ_Severe_Burning_Pain_Last_Event | ||||
| PX220801330702 | Neurologic System Questions - Last event | N/A | ||
| PX220801_CCHS_NSQ_Severe_Burning_Pain_Medical_Attention | ||||
| PX220801330802 | Neurologic System Questions - Did you seek more | N/A | ||
| PX220801_CCHS_NSQ_Severe_Burning_Pain_Severity | ||||
| PX220801330202 | Neurologic System Questions - How severe is more | N/A | ||
| PX220801_CCHS_NSQ_Severe_Burning_Pain_Time | ||||
| PX220801330402 | Neurologic System Questions - When do more | N/A | ||
| PX220801_CCHS_OQ_Droopy_Eyelids | ||||
| PX220801360100 | Ocular Questions - Do you have droopy eyelids? | N/A | ||
| PX220801_CCHS_OQ_Droopy_Eyelids_Age | ||||
| PX220801360400 | Ocular Questions - Age at onset of symptoms | N/A | ||
| PX220801_CCHS_OQ_Droopy_Eyelids_Associated_Factor | ||||
| PX220801360600 | Ocular Questions - Associated with any other more | N/A | ||
| PX220801_CCHS_OQ_Droopy_Eyelids_Diagnosis | ||||
| PX220801361000 | Ocular Questions - If yes, was a diagnosis made? | N/A | ||
| PX220801_CCHS_OQ_Droopy_Eyelids_Eye | ||||
| PX220801360200 | Ocular Questions - which eye? | N/A | ||
| PX220801_CCHS_OQ_Droopy_Eyelids_Frequency | ||||
| PX220801360700 | Ocular Questions - How often: | N/A | ||
| PX220801_CCHS_OQ_Droopy_Eyelids_Last_Event | ||||
| PX220801360800 | Ocular Questions - Last event | N/A | ||
| PX220801_CCHS_OQ_Droopy_Eyelids_Medical_Attention | ||||
| PX220801360900 | Ocular Questions - Did you seek medical more | N/A | ||
| PX220801_CCHS_OQ_Droopy_Eyelids_Severity | ||||
| PX220801360300 | Ocular Questions - How severe is this problem? | N/A | ||
| PX220801_CCHS_OQ_Droopy_Eyelids_Time | ||||
| PX220801360500 | Ocular Questions - When do symptoms occur: | N/A | ||
| PX220801_CCHS_OQ_Respond_To_Light | ||||
| PX220801370100 | Ocular Questions - Were you told that your more | N/A | ||
| PX220801_CCHS_OQ_Respond_To_Light_Age | ||||
| PX220801370400 | Ocular Questions - Age at onset of symptoms | N/A | ||
| PX220801_CCHS_OQ_Respond_To_Light_Associated_Factor | ||||
| PX220801370600 | Ocular Questions - Associated with any other more | N/A | ||
| PX220801_CCHS_OQ_Respond_To_Light_Diagnosis | ||||
| PX220801371000 | Ocular Questions - If yes, was a diagnosis made? | N/A | ||
| PX220801_CCHS_OQ_Respond_To_Light_Eye | ||||
| PX220801370200 | Ocular Questions - which eye? | N/A | ||
| PX220801_CCHS_OQ_Respond_To_Light_Frequency | ||||
| PX220801370700 | Ocular Questions - How often: | N/A | ||
| PX220801_CCHS_OQ_Respond_To_Light_Last_Event | ||||
| PX220801370800 | Ocular Questions - Last event | N/A | ||
| PX220801_CCHS_OQ_Respond_To_Light_Medical_Attention | ||||
| PX220801370900 | Ocular Questions - Did you seek medical more | N/A | ||
| PX220801_CCHS_OQ_Respond_To_Light_Severity | ||||
| PX220801370300 | Ocular Questions - How severe is this problem? | N/A | ||
| PX220801_CCHS_OQ_Respond_To_Light_Time | ||||
| PX220801370500 | Ocular Questions - When do symptoms occur: | N/A | ||
| PX220801_CCHS_OQ_Tearing_Problem | ||||
| PX220801390100 | Ocular Questions - Have you had problems more | N/A | ||
| PX220801_CCHS_OQ_Tearing_Problem_Age | ||||
| PX220801390300 | Ocular Questions - Age at onset of symptoms | N/A | ||
| PX220801_CCHS_OQ_Tearing_Problem_Associated_Factor | ||||
| PX220801390500 | Ocular Questions - Associated with any other more | N/A | ||
| PX220801_CCHS_OQ_Tearing_Problem_Diagnosis | ||||
| PX220801390900 | Ocular Questions - If yes, was a diagnosis made? | N/A | ||
| PX220801_CCHS_OQ_Tearing_Problem_Frequency | ||||
| PX220801390600 | Ocular Questions - How often: | N/A | ||
| PX220801_CCHS_OQ_Tearing_Problem_Last_Event | ||||
| PX220801390700 | Ocular Questions - Last event | N/A | ||
| PX220801_CCHS_OQ_Tearing_Problem_Medical_Attention | ||||
| PX220801390800 | Ocular Questions - Did you seek medical more | N/A | ||
| PX220801_CCHS_OQ_Tearing_Problem_Severity | ||||
| PX220801390200 | Ocular Questions - How severe is this problem? | N/A | ||
| PX220801_CCHS_OQ_Tearing_Problem_Time | ||||
| PX220801390400 | Ocular Questions - When do symptoms occur: | N/A | ||
| PX220801_CCHS_OQ_Tightly_Constricted_Pupils | ||||
| PX220801380100 | Ocular Questions - Do you have tightly more | N/A | ||
| PX220801_CCHS_OQ_Tightly_Constricted_Pupils_Age | ||||
| PX220801380400 | Ocular Questions - Age at onset of symptoms | N/A | ||
| PX220801_CCHS_OQ_Tightly_Constricted_Pupils_Associated_Factor | ||||
| PX220801380600 | Ocular Questions - Associated with any other more | N/A | ||
| PX220801_CCHS_OQ_Tightly_Constricted_Pupils_Diagnosis | ||||
| PX220801381000 | Ocular Questions - If yes, was a diagnosis made? | N/A | ||
| PX220801_CCHS_OQ_Tightly_Constricted_Pupils_Eye | ||||
| PX220801380200 | Ocular Questions - which eye? | N/A | ||
| PX220801_CCHS_OQ_Tightly_Constricted_Pupils_Frequency | ||||
| PX220801380700 | Ocular Questions - How often: | N/A | ||
| PX220801_CCHS_OQ_Tightly_Constricted_Pupils_Last_Event | ||||
| PX220801380800 | Ocular Questions - Last event | N/A | ||
| PX220801_CCHS_OQ_Tightly_Constricted_Pupils_Medical_Attention | ||||
| PX220801380900 | Ocular Questions - Did you seek medical more | N/A | ||
| PX220801_CCHS_OQ_Tightly_Constricted_Pupils_Severity | ||||
| PX220801380300 | Ocular Questions - How severe is this problem? | N/A | ||
| PX220801_CCHS_OQ_Tightly_Constricted_Pupils_Time | ||||
| PX220801380500 | Ocular Questions - When do symptoms occur: | N/A | ||
| PX220801_CCHS_OQ_Unequal_Pupils | ||||
| PX220801350100 | Ocular Questions - Do you have unequal pupils? | N/A | ||
| PX220801_CCHS_OQ_Unequal_Pupils_Age | ||||
| PX220801350300 | Ocular Questions - Age at onset of symptoms | N/A | ||
| PX220801_CCHS_OQ_Unequal_Pupils_Associated_Factor | ||||
| PX220801350500 | Ocular Questions - Associated with any other more | N/A | ||
| PX220801_CCHS_OQ_Unequal_Pupils_Diagnosis | ||||
| PX220801350900 | Ocular Questions - If yes, was a diagnosis made? | N/A | ||
| PX220801_CCHS_OQ_Unequal_Pupils_Frequency | ||||
| PX220801350600 | Ocular Questions - How often: | N/A | ||
| PX220801_CCHS_OQ_Unequal_Pupils_Last_Event | ||||
| PX220801350700 | Ocular Questions - Last event | N/A | ||
| PX220801_CCHS_OQ_Unequal_Pupils_Medical_Attention | ||||
| PX220801350800 | Ocular Questions - Did you seek medical more | N/A | ||
| PX220801_CCHS_OQ_Unequal_Pupils_Severity | ||||
| PX220801350200 | Ocular Questions - How severe is this problem? | N/A | ||
| PX220801_CCHS_OQ_Unequal_Pupils_Time | ||||
| PX220801350400 | Ocular Questions - When do symptoms occur: | N/A | ||
| PX220801_CCHS_OQ_Vision_Accommodating_Trouble | ||||
| PX220801400100 | Ocular Questions - Have you ever had trouble more | N/A | ||
| PX220801_CCHS_OQ_Vision_Accommodating_Trouble_Age | ||||
| PX220801400300 | Ocular Questions - Age at onset of symptoms | N/A | ||
| PX220801_CCHS_OQ_Vision_Accommodating_Trouble_Associated_Factor | ||||
| PX220801400500 | Ocular Questions - Associated with any other more | N/A | ||
| PX220801_CCHS_OQ_Vision_Accommodating_Trouble_Diagnosis | ||||
| PX220801400900 | Ocular Questions - If yes, was a diagnosis made? | N/A | ||
| PX220801_CCHS_OQ_Vision_Accommodating_Trouble_Frequency | ||||
| PX220801400600 | Ocular Questions - How often: | N/A | ||
| PX220801_CCHS_OQ_Vision_Accommodating_Trouble_Last_Event | ||||
| PX220801400700 | Ocular Questions - Last event | N/A | ||
| PX220801_CCHS_OQ_Vision_Accommodating_Trouble_Medical_Attention | ||||
| PX220801400800 | Ocular Questions - Did you seek medical more | N/A | ||
| PX220801_CCHS_OQ_Vision_Accommodating_Trouble_Severity | ||||
| PX220801400200 | Ocular Questions - How severe is this problem? | N/A | ||
| PX220801_CCHS_OQ_Vision_Accommodating_Trouble_Time | ||||
| PX220801400400 | Ocular Questions - When do symptoms occur: | N/A | ||
| PX220801_CCHS_POCT_72_Hour_Holter | ||||
| PX220801810100 | Physiologic and other clinical testing - more | N/A | ||
| PX220801_CCHS_POCT_Autonomic_Testing | ||||
| PX220801850100 | Physiologic and other clinical testing - Age more | N/A | ||
| PX220801_CCHS_POCT_Chest_Abdomen_Movement | ||||
| PX220801750100 | Physiologic and other clinical testing - more | N/A | ||
| PX220801_CCHS_POCT_ECG | ||||
| PX220801790100 | Physiologic and other clinical testing - ECG | Variable Mapping | ||
| PX220801_CCHS_POCT_End_Tidal_Carbon_Dioxide | ||||
| PX220801780100 | Physiologic and other clinical testing - End more | N/A | ||
| PX220801_CCHS_POCT_Exogenous_Endogenous_Ventilatory_Challenges | ||||
| PX220801800100 | Physiologic and other clinical testing - more | N/A | ||
| PX220801_CCHS_POCT_Hemoglobin_Saturation | ||||
| PX220801770100 | Physiologic and other clinical testing - more | N/A | ||
| PX220801_CCHS_POCT_Hirschsprung_Disease | ||||
| PX220801840100 | Physiologic and other clinical testing - more | N/A | ||
| PX220801_CCHS_POCT_Neural_Crest_Tumors | ||||
| PX220801830100 | Physiologic and other clinical testing - more | N/A | ||
| PX220801_CCHS_POCT_Neurocognitive_Testing | ||||
| PX220801820100 | Physiologic and other clinical testing - more | N/A | ||
| PX220801_CCHS_POCT_Respiratory_Frequencye | ||||
| PX220801760100 | Physiologic and other clinical testing - more | Variable Mapping | ||
| PX220801_CCHS_POCT_Tidal_Volume | ||||
| PX220801740100 | Physiologic and other clinical testing - more | N/A | ||
| PX220801_CCHS_PSQ_Anxiety | ||||
| PX220801410100 | Psychological System Questions - Have you more | Variable Mapping | ||
| PX220801_CCHS_PSQ_Anxiety_Age | ||||
| PX220801410300 | Psychological System Questions - Age at more | Variable Mapping | ||
| PX220801_CCHS_PSQ_Anxiety_Associated_Factor | ||||
| PX220801410500 | Psychological System Questions - Associated more | N/A | ||
| PX220801_CCHS_PSQ_Anxiety_Diagnosis | ||||
| PX220801410900 | Psychological System Questions - If yes, was more | N/A | ||
| PX220801_CCHS_PSQ_Anxiety_Frequency | ||||
| PX220801410600 | Psychological System Questions - How often: | Variable Mapping | ||
| PX220801_CCHS_PSQ_Anxiety_Last_Event | ||||
| PX220801410700 | Psychological System Questions - Last event | N/A | ||
| PX220801_CCHS_PSQ_Anxiety_Medical_Attention | ||||
| PX220801410800 | Psychological System Questions - Did you more | N/A | ||
| PX220801_CCHS_PSQ_Anxiety_Severity | ||||
| PX220801410200 | Psychological System Questions - How severe more | Variable Mapping | ||
| PX220801_CCHS_PSQ_Anxiety_Time | ||||
| PX220801410400 | Psychological System Questions - When do more | N/A | ||
| PX220801_CCHS_PSQ_Eye_Contact_Problem | ||||
| PX220801430200 | Psychological System Questions - Have you more | N/A | ||
| PX220801_CCHS_PSQ_Learning_Disability | ||||
| PX220801420100 | Psychological System Questions - Have you more | N/A | ||
| PX220801_CCHS_PSQ_Learning_Disability_Age | ||||
| PX220801420300 | Psychological System Questions - Age at more | N/A | ||
| PX220801_CCHS_PSQ_Learning_Disability_Associated_Other | ||||
| PX220801420500 | Psychological System Questions - Is the more | N/A | ||
| PX220801_CCHS_PSQ_Learning_Disability_Diagnosis | ||||
| PX220801420800 | Psychological System Questions - If yes, was more | N/A | ||
| PX220801_CCHS_PSQ_Learning_Disability_Frequency | ||||
| PX220801420600 | Psychological System Questions - How often: | N/A | ||
| PX220801_CCHS_PSQ_Learning_Disability_Medical_Attention | ||||
| PX220801420700 | Psychological System Questions - Did you more | N/A | ||
| PX220801_CCHS_PSQ_Learning_Disability_Medication | ||||
| PX220801420900 | Psychological System Questions - Was more | N/A | ||
| PX220801_CCHS_PSQ_Learning_Disability_Severity | ||||
| PX220801420200 | Psychological System Questions - How severe more | N/A | ||
| PX220801_CCHS_PSQ_Learning_Disability_Time | ||||
| PX220801420400 | Psychological System Questions - When do more | N/A | ||
| PX220801_CCHS_PSQ_Recognizing_Social_Cues | ||||
| PX220801430100 | Psychological System Questions - Have you more | N/A | ||
| PX220801_CCHS_PSQ_Recognizing_Social_Cues_Comprehend | ||||
| PX220801430300 | Psychological System Questions - Do you more | N/A | ||
| PX220801_CCHS_PSQ_Recognizing_Social_Cues_Inability | ||||
| PX220801430400 | Psychological System Questions - Do you have more | N/A | ||
| PX220801_CCHS_RSQ_Home_Monitor | ||||
| PX220801570100 | Respiratory System Questions - Has anyone in more | N/A | ||
| PX220801_CCHS_RSQ_Loss_Of_Libido | ||||
| PX220801480100 | Reproductive System Questions - - Have you more | N/A | ||
| PX220801_CCHS_RSQ_Loss_Of_Libido_Age | ||||
| PX220801480300 | Reproductive System Questions - Age at onset more | N/A | ||
| PX220801_CCHS_RSQ_Loss_Of_Libido_Associated_Other | ||||
| PX220801480500 | Reproductive System Questions - Is the loss more | N/A | ||
| PX220801_CCHS_RSQ_Loss_Of_Libido_Diagnosis | ||||
| PX220801480900 | Reproductive System Questions - If yes, was more | N/A | ||
| PX220801_CCHS_RSQ_Loss_Of_Libido_Frequency | ||||
| PX220801480600 | Reproductive System Questions - How often: | N/A | ||
| PX220801_CCHS_RSQ_Loss_Of_Libido_Last_Event | ||||
| PX220801480700 | Reproductive System Questions - Last event | N/A | ||
| PX220801_CCHS_RSQ_Loss_Of_Libido_Medical_Attention | ||||
| PX220801480800 | Reproductive System Questions - Did you seek more | N/A | ||
| PX220801_CCHS_RSQ_Loss_Of_Libido_Severity | ||||
| PX220801480200 | Reproductive System Questions - How severe more | N/A | ||
| PX220801_CCHS_RSQ_Loss_Of_Libido_Time | ||||
| PX220801480400 | Reproductive System Questions - When do more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Alveolar_Hypoventilation | ||||
| PX220801540100 | Respiratory System Questions - Have you ever more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Alveolar_Hypoventilation_Age | ||||
| PX220801540300 | Respiratory System Questions - Age at onset more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Alveolar_Hypoventilation_Associated_Other | ||||
| PX220801540500 | Respiratory System Questions - Is the more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Alveolar_Hypoventilation_Diagnosis | ||||
| PX220801540900 | Respiratory System Questions - If yes, was a more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Alveolar_Hypoventilation_Frequency | ||||
| PX220801540600 | Respiratory System Questions - How often: | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Alveolar_Hypoventilation_Last_Event | ||||
| PX220801540700 | Respiratory System Questions - Last event | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Alveolar_Hypoventilation_Medical_Attention | ||||
| PX220801540800 | Respiratory System Questions - Did you seek more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Alveolar_Hypoventilation_Severity | ||||
| PX220801540200 | Respiratory System Questions - How severe is more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Alveolar_Hypoventilation_Time | ||||
| PX220801540400 | Respiratory System Questions - When do more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Apnea | ||||
| PX220801530100 | Respiratory System Questions - Have you ever more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Apnea_Age | ||||
| PX220801530300 | Respiratory System Questions - Age at onset more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Apnea_Associated_Other | ||||
| PX220801530500 | Respiratory System Questions - Is the more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Apnea_Diagnosis | ||||
| PX220801530900 | Respiratory System Questions - If yes, was a more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Apnea_Frequency | ||||
| PX220801530600 | Respiratory System Questions - How often: | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Apnea_Last_Event | ||||
| PX220801530700 | Respiratory System Questions - Last event | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Apnea_Medical_Attention | ||||
| PX220801530800 | Respiratory System Questions - Did you seek more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Apnea_Severity | ||||
| PX220801530200 | Respiratory System Questions - How severe is more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Apnea_Time | ||||
| PX220801530400 | Respiratory System Questions - When do more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Breath_Holding_Spells | ||||
| PX220801550100 | Respiratory System Questions - Have you ever more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Breath_Holding_Spells_Age | ||||
| PX220801550300 | Respiratory System Questions - Age at onset more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Breath_Holding_Spells_Associated_Other | ||||
| PX220801550500 | Respiratory System Questions - Is the more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Breath_Holding_Spells_Diagnosis | ||||
| PX220801550900 | Respiratory System Questions - If yes, was a more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Breath_Holding_Spells_Frequency | ||||
| PX220801550600 | Respiratory System Questions - How often: | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Breath_Holding_Spells_Last_Event | ||||
| PX220801550700 | Respiratory System Questions - Last event | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Breath_Holding_Spells_Medical_Attention | ||||
| PX220801550800 | Respiratory System Questions - Did you seek more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Breath_Holding_Spells_Severity | ||||
| PX220801550200 | Respiratory System Questions - How severe is more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Breath_Holding_Spells_Time | ||||
| PX220801550400 | Respiratory System Questions - When do more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Erection | ||||
| PX220801490100 | Reproductive System Questions - Have you had more | Variable Mapping | ||
| PX220801_CCHS_RSQ_Problems_With_Erection_Age | ||||
| PX220801490300 | Reproductive System Questions - Age at onset more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Erection_Associated_Other | ||||
| PX220801490500 | Reproductive System Questions - Is the more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Erection_Diagnosis | ||||
| PX220801490900 | Reproductive System Questions - If yes, was more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Erection_Frequency | ||||
| PX220801490600 | Reproductive System Questions - How often: | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Erection_Last_Event | ||||
| PX220801490700 | Reproductive System Questions - Last event | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Erection_Medical_Attention | ||||
| PX220801490800 | Reproductive System Questions - Did you seek more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Erection_Severity | ||||
| PX220801490200 | Reproductive System Questions - How severe more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Erection_Time | ||||
| PX220801490400 | Reproductive System Questions - When do more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Priapism | ||||
| PX220801500100 | Reproductive System Questions - Have you had more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Priapism_Age | ||||
| PX220801500300 | Reproductive System Questions - Age at onset more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Priapism_Associated_Other | ||||
| PX220801500500 | Reproductive System Questions - Is the more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Priapism_Diagnosis | ||||
| PX220801500900 | Reproductive System Questions - If yes, was more | Variable Mapping | ||
| PX220801_CCHS_RSQ_Problems_With_Priapism_Frequency | ||||
| PX220801500600 | Reproductive System Questions - How often: | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Priapism_Last_Event | ||||
| PX220801500700 | Reproductive System Questions - Last event | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Priapism_Medical_Attention | ||||
| PX220801500800 | Reproductive System Questions - Did you seek more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Priapism_Severity | ||||
| PX220801500200 | Reproductive System Questions - How severe more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Priapism_Time | ||||
| PX220801500400 | Reproductive System Questions - When do more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Sigh | ||||
| PX220801520100 | Respiratory System Questions - Do you notice more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Sigh_Age | ||||
| PX220801520300 | Respiratory System Questions - Age at onset more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Sigh_Associated_Other | ||||
| PX220801520500 | Respiratory System Questions - Is the more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Sigh_Diagnosis | ||||
| PX220801520900 | Respiratory System Questions - If yes, was a more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Sigh_Frequency | ||||
| PX220801520600 | Respiratory System Questions - How often: | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Sigh_Last_Event | ||||
| PX220801520700 | Respiratory System Questions - Last event | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Sigh_Medical_Attention | ||||
| PX220801520800 | Respiratory System Questions - Did you seek more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Sigh_Severity | ||||
| PX220801520200 | Respiratory System Questions - How severe is more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Sigh_Time | ||||
| PX220801520400 | Respiratory System Questions - When do more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Stridor | ||||
| PX220801510100 | Respiratory System Questions - Have you had more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Stridor_Age | ||||
| PX220801510300 | Respiratory System Questions - Age at onset more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Stridor_Associated_Other | ||||
| PX220801510500 | Respiratory System Questions - Is the more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Stridor_Diagnosis | ||||
| PX220801510900 | Respiratory System Questions - If yes, was a more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Stridor_Frequency | ||||
| PX220801510600 | Respiratory System Questions - How often: | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Stridor_Last_Event | ||||
| PX220801510700 | Respiratory System Questions - Last event | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Stridor_Medical_Attention | ||||
| PX220801510800 | Respiratory System Questions - Did you seek more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Stridor_Severity | ||||
| PX220801510200 | Respiratory System Questions - How severe is more | N/A | ||
| PX220801_CCHS_RSQ_Problems_With_Stridor_Time | ||||
| PX220801510400 | Respiratory System Questions - When do more | N/A | ||
| PX220801_CCHS_RSQ_SIDS_Death | ||||
| PX220801560100 | Respiratory System Questions - Has there more | Variable Mapping | ||
| PX220801_CCHS_RUSQ_Frequent_Urination | ||||
| PX220801450100 | Renal and Urinary System Questions - Have more | N/A | ||
| PX220801_CCHS_RUSQ_Frequent_Urination_Age | ||||
| PX220801450300 | Renal and Urinary System Questions - Age at more | N/A | ||
| PX220801_CCHS_RUSQ_Frequent_Urination_Associated_Other | ||||
| PX220801450500 | Renal and Urinary System Questions - Is the more | N/A | ||
| PX220801_CCHS_RUSQ_Frequent_Urination_Diagnosis | ||||
| PX220801450900 | Renal and Urinary System Questions - If yes, more | N/A | ||
| PX220801_CCHS_RUSQ_Frequent_Urination_Frequency | ||||
| PX220801450600 | Renal and Urinary System Questions - How often: | N/A | ||
| PX220801_CCHS_RUSQ_Frequent_Urination_Last_Event | ||||
| PX220801450700 | Renal and Urinary System Questions - Last event | N/A | ||
| PX220801_CCHS_RUSQ_Frequent_Urination_Medical_Attention | ||||
| PX220801450800 | Renal and Urinary System Questions - Did you more | N/A | ||
| PX220801_CCHS_RUSQ_Frequent_Urination_Severity | ||||
| PX220801450200 | Renal and Urinary System Questions - How more | N/A | ||
| PX220801_CCHS_RUSQ_Frequent_Urination_Time | ||||
| PX220801450400 | Renal and Urinary System Questions - When do more | N/A | ||
| PX220801_CCHS_RUSQ_Retaining_Urine | ||||
| PX220801440100 | Renal and Urinary System Questions - Have more | N/A | ||
| PX220801_CCHS_RUSQ_Retaining_Urine_Age | ||||
| PX220801440300 | Renal and Urinary System Questions - Age at more | N/A | ||
| PX220801_CCHS_RUSQ_Retaining_Urine_Associated_Other | ||||
| PX220801440500 | Renal and Urinary System Questions - Is the more | N/A | ||
| PX220801_CCHS_RUSQ_Retaining_Urine_Diagnosis | ||||
| PX220801440900 | Renal and Urinary System Questions - If yes, more | N/A | ||
| PX220801_CCHS_RUSQ_Retaining_Urine_Frequency | ||||
| PX220801440600 | Renal and Urinary System Questions - How often: | N/A | ||
| PX220801_CCHS_RUSQ_Retaining_Urine_Last_Event | ||||
| PX220801440700 | Renal and Urinary System Questions - Last event | N/A | ||
| PX220801_CCHS_RUSQ_Retaining_Urine_Medical_Attention | ||||
| PX220801440800 | Renal and Urinary System Questions - Did you more | N/A | ||
| PX220801_CCHS_RUSQ_Retaining_Urine_Severity | ||||
| PX220801440200 | Renal and Urinary System Questions - How more | N/A | ||
| PX220801_CCHS_RUSQ_Retaining_Urine_Time | ||||
| PX220801440400 | Renal and Urinary System Questions - When do more | N/A | ||
| PX220801_CCHS_RUSQ_Urgency_To_Urinate | ||||
| PX220801460100 | Renal and Urinary System Questions - Have more | N/A | ||
| PX220801_CCHS_RUSQ_Urgency_To_Urinate_Age | ||||
| PX220801460300 | Renal and Urinary System Questions - Age at more | N/A | ||
| PX220801_CCHS_RUSQ_Urgency_To_Urinate_Associated_Other | ||||
| PX220801460500 | Renal and Urinary System Questions - Is the more | N/A | ||
| PX220801_CCHS_RUSQ_Urgency_To_Urinate_Diagnosis | ||||
| PX220801460900 | Renal and Urinary System Questions - If yes, more | N/A | ||
| PX220801_CCHS_RUSQ_Urgency_To_Urinate_Frequency | ||||
| PX220801460600 | Renal and Urinary System Questions - How often: | N/A | ||
| PX220801_CCHS_RUSQ_Urgency_To_Urinate_Last_Event | ||||
| PX220801460700 | Renal and Urinary System Questions - Last event | N/A | ||
| PX220801_CCHS_RUSQ_Urgency_To_Urinate_Medical_Attention | ||||
| PX220801460800 | Renal and Urinary System Questions - Did you more | N/A | ||
| PX220801_CCHS_RUSQ_Urgency_To_Urinate_Severity | ||||
| PX220801460200 | Renal and Urinary System Questions - How more | N/A | ||
| PX220801_CCHS_RUSQ_Urgency_To_Urinate_Time | ||||
| PX220801460400 | Renal and Urinary System Questions - When do more | N/A | ||
| PX220801_CCHS_RUSQ_Urinary_Incontinence | ||||
| PX220801470100 | Renal and Urinary System Questions - Have more | Variable Mapping | ||
| PX220801_CCHS_RUSQ_Urinary_Incontinence_Age | ||||
| PX220801470300 | Renal and Urinary System Questions - Age at more | N/A | ||
| PX220801_CCHS_RUSQ_Urinary_Incontinence_Associated_Other | ||||
| PX220801470500 | Renal and Urinary System Questions - Is the more | N/A | ||
| PX220801_CCHS_RUSQ_Urinary_Incontinence_Diagnosis | ||||
| PX220801470900 | Renal and Urinary System Questions - If yes, more | N/A | ||
| PX220801_CCHS_RUSQ_Urinary_Incontinence_Frequency | ||||
| PX220801470600 | Renal and Urinary System Questions - How often: | N/A | ||
| PX220801_CCHS_RUSQ_Urinary_Incontinence_Last_Event | ||||
| PX220801470700 | Renal and Urinary System Questions - Last event | N/A | ||
| PX220801_CCHS_RUSQ_Urinary_Incontinence_Medical_Attention | ||||
| PX220801470800 | Renal and Urinary System Questions - Did you more | N/A | ||
| PX220801_CCHS_RUSQ_Urinary_Incontinence_Severity | ||||
| PX220801470200 | Renal and Urinary System Questions - How more | N/A | ||
| PX220801_CCHS_RUSQ_Urinary_Incontinence_Time | ||||
| PX220801470400 | Renal and Urinary System Questions - When do more | N/A | ||
| PX220801_CCHS_SSQ_Problems_With_Difficulty_Sweating | ||||
| PX220801580100 | Sudomotor System Questions - Have you ever more | N/A | ||
| PX220801_CCHS_SSQ_Problems_With_Difficulty_Sweating_Age | ||||
| PX220801580300 | Sudomotor System Questions - Age at onset of more | N/A | ||
| PX220801_CCHS_SSQ_Problems_With_Difficulty_Sweating_Associated_Other | ||||
| PX220801580500 | Sudomotor System Questions - Is the problems more | N/A | ||
| PX220801_CCHS_SSQ_Problems_With_Difficulty_Sweating_Diagnosis | ||||
| PX220801580900 | Sudomotor System Questions - If yes, was a more | N/A | ||
| PX220801_CCHS_SSQ_Problems_With_Difficulty_Sweating_Frequency | ||||
| PX220801580600 | Sudomotor System Questions - How often: | N/A | ||
| PX220801_CCHS_SSQ_Problems_With_Difficulty_Sweating_Last_Event | ||||
| PX220801580700 | Sudomotor System Questions - Last event | N/A | ||
| PX220801_CCHS_SSQ_Problems_With_Difficulty_Sweating_Medical_Attention | ||||
| PX220801580800 | Sudomotor System Questions - Did you seek more | N/A | ||
| PX220801_CCHS_SSQ_Problems_With_Difficulty_Sweating_Severity | ||||
| PX220801580200 | Sudomotor System Questions - How severe is more | N/A | ||
| PX220801_CCHS_SSQ_Problems_With_Difficulty_Sweating_Time | ||||
| PX220801580400 | Sudomotor System Questions - When do more | N/A | ||
Measure Name
Disorders of Respiratory Control with Inherent Autonomic Dysregulation
Release Date
April 30, 2015
Definition
The measure is used to assess dysregulation of the autonomic nervous system and whether the individual may have characteristic autonomic dysregulation as anticipated in congenital central hypoventilation syndrome (CCHS).
Purpose
Congenital central hypoventilation syndrome (CCHS) represents the extreme end of a spectrum of autonomic nervous system dysregulation, characterized by hypoventilation during sleep (and, in more severe cases, during wakefulness and sleep), with markedly diminished or absent ventilatory responses to hypoxia/hypercarbia, coupled with signs of autonomic dysfunction.
Keywords
Pulmonary, respiratory control, congenital central hypoventilation syndrome, CCHS, paired-like homeobox gene, PHOX2B gene, autonomic nervous system dysfunction, ANSD, pediatric, birth, autonomic dysregulation, breathing, genetic, Autonomic Nervous System Questionnaire, ANSQ
Measure Protocols
| Protocol ID | Protocol Name |
|---|---|
| 220801 | Disorders of Respiratory Control with Inherent Autonomic Dysregulation |
Publications
There are no publications listed for this protocol.