Protocol - Family History of Pregnancy Complications

Description

A two-item, multi-part set of interviewer-administered questions about the woman’s family members who have had pregnancy complications. The relationship between the woman and her family members and the list of pregnancy complications are coded.

Specific Instructions

None

Availability

Available

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Protocol

1. Have any of your biological mother, sisters, half-sisters, or female first cousins ever had any of the following pregnancy complications?

a. Delivery of a child more than 3 weeks before the expected due date

01[ ]Yes

02[ ]No

-8[ ]Don’t know

b. Delivery of a child weighing less than 5 lb 8 oz (or 2500 grams)

01[ ]Yes

02[ ]No

-8[ ]Don’t know

c. Spontaneous preterm delivery (<37 weeks)

01[ ]Yes

02[ ]No

-8[ ]Don’t know

d. Early or preterm rupture of the membranes

01[ ]Yes

02[ ]No

-8[ ]Don’t know

e. Preeclampsia, eclampsia, toxemia, or pregnancy-induced hypertension

01[ ]Yes

02[ ]No

-8[ ]Don’t know

f. Induction of labor due to low amniotic fluid or poor fetal growth

01[ ]Yes

02[ ]No

-8[ ]Don’t know

g. Stillbirth

01[ ]Yes

02[ ]No

-8[ ]Don’t know

h. Delivery of an infant with a birth defect

01[ ]Yes

02[ ]No

-8[ ]Don’t know

i. Other pregnancy complication, specify

01[ ]Yes

02[ ]No

-8[ ]Don’t know

1. Specify ____________________

IF YES TO ANY OF THE ABOVE [COMPLETE #2]

IF NO OR DON’T KNOW TO ALL OF THE ABOVE [END]

2. For each family member, tell me the relation and the pregnancy complications. (Use codes in lists below)

Code Family Relation and up to five pregnancy complications for any family member

a. Family relation code ________

Pregnancy complication 1 _________

Pregnancy complication 2 _________

Pregnancy complication 3 _________

Pregnancy complication 4 _________

Pregnancy complication 5 _________

Other specify pregnancy complication 1 _________

Other specify pregnancy complication 2 _________

b. Family relation code ________

Pregnancy complication 1 _________

Pregnancy complication 2 _________

Pregnancy complication 3 _________

Pregnancy complication 4 _________

Pregnancy complication 5 _________

Other specify pregnancy complication 1 _________

Other specify pregnancy complication 2 _________

c. Family relation code ________

Pregnancy complication 1 _________

Pregnancy complication 2 _________

Pregnancy complication 3 _________

Pregnancy complication 4 _________

Pregnancy complication 5 _________

Other specify pregnancy complication 1 _________

Other specify pregnancy complication 2 _________

d. Family relation code ________

Pregnancy complication 1 _________

Pregnancy complication 2 _________

Pregnancy complication 3 _________

Pregnancy complication 4 _________

Pregnancy complication 5 _________

Other specify pregnancy complication 1 _________

Other specify pregnancy complication 2 _________

e. Family relation code ________

Pregnancy complication 1 _________

Pregnancy complication 2 _________

Pregnancy complication 3 _________

Pregnancy complication 4 _________

Pregnancy complication 5 _________

Other specify pregnancy complication 1 _________

Other specify pregnancy complication 2 _________

Codes for Question #2

Codes for Family Relation to Participant

01 = Participant’s mother

02 = Participant’s sister/half-sister

03 = Participant’s female first cousin, maternal

04 = Participant’s female first cousin, paternal

Codes for Pregnancy Complication

01 = Delivery of a child more than 3 weeks before the expected due date

02 = Delivery of a child weighing less than 5 lb 8 oz (or 2500 grams)

03 = Spontaneous preterm delivery (<37 weeks)

04 = Early or preterm rupture of the membranes

05 = Preeclampsia, eclampsia, toxemia or pregnancy induced hypertension

06 = Induction of labor due to low amniotic fluid or poor fetal growth

07 = Stillbirth

08 = Delivery of an infant with a birth defect

09 = Other pregnancy complication (SPECIFY)

Personnel and Training Required

None

Equipment Needs

None

Requirements

Requirement Category	Required
Major equipment	No
Specialized training	No
Specialized requirements for biospecimen collection	No
Average time of greater than 15 minutes in an unaffected individual	No

Mode of Administration

Interviewer-administered questionnaire

Lifestage

Adult, Pregnancy

Participants

Pregnant women

Selection Rationale

The Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-Be (nuMoM2b) is a major prospective cohort study collecting data from the first trimester of pregnancy through the end of pregnancy on approximately 10,000 nulliparous women. The protocols, consent forms, and data collection instruments were developed by the nuMoM2b investigators in collaboration with Project Scientists from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and vetted by an independent Advisory and Safety Monitoring Board reporting to NICHD.

Language

English

Standards

Standard	Name	ID	Source
caDSR Form	PhenX PX240801 - Family History Of Pregnancy Complications	6886110	caDSR Form

Derived Variables

None

Process and Review

Not applicable.

Protocol Name from Source

Nulliparous Pregnancy Outcomes Study Monitoring Mothers-to-Be (nuMoM2b), Difficulties in Pregnancy, 2011

Source

Nulliparous Pregnancy Outcomes Study Monitoring Mothers-to-Be (nuMoM2b) Difficulties in Pregnancy, Maternal Interview Visit 2, version 4, Form V2A, December 9, 2011. Questions 6 & 7.

General References

Haas, D. M., Parker, C. B., Wing, D. A., Parry, S., Grobman, W. A., Mercer, B. M., Simhan, H. N., Hoffman, M. K., Silver, R. M., Wadhwa, P., Iams, J. D., Koch, M. A., Caritis, S. N., Wapner, R. J., Esplin, M. S., Elovitz, M. A., Foroud, T., Peaceman, A. M., Saade, G. R., Willinger, M., & Reddy, U. M. (2015). NuMoM2b study. American Journal of Obstetrics and Gynecology, 212(4), 539.e1--539.e24.

Protocol ID

240801

Variables

Export Variables

Variable Name	Variable ID	Variable Description	dbGaP Mapping
PX240801_Pregnancy_History_Birth_Defect
	PX240801010800	Have any of your biological mother, sisters, more half-sisters, or female first cousins ever had the following pregnancy complication? Delivery of an infant with a birth defect show less	N/A
PX240801_Pregnancy_History_Family_1_Complication_1
	PX240801020102	Family member #1: Pregnancy complication #1	N/A
PX240801_Pregnancy_History_Family_1_Complication_2
	PX240801020103	Family member #1: Pregnancy complication #2	N/A
PX240801_Pregnancy_History_Family_1_Complication_3
	PX240801020104	Family member #1: Pregnancy complication #3	N/A
PX240801_Pregnancy_History_Family_1_Complication_4
	PX240801020105	Family member #1: Pregnancy complication #4	N/A
PX240801_Pregnancy_History_Family_1_Complication_5
	PX240801020106	Family member #1: Pregnancy complication #5	N/A
PX240801_Pregnancy_History_Family_1_Relation
	PX240801020101	Family member #1: What is his or her family more relation? show less	N/A
PX240801_Pregnancy_History_Family_2_Complication_1
	PX240801020202	Family member #2: Pregnancy complication #1	N/A
PX240801_Pregnancy_History_Family_2_Complication_2
	PX240801020203	Family member #2: Pregnancy complication #2	N/A
PX240801_Pregnancy_History_Family_2_Complication_3
	PX240801020204	Family member #2: Pregnancy complication #3	N/A
PX240801_Pregnancy_History_Family_2_Complication_4
	PX240801020205	Family member #2: Pregnancy complication #4	N/A
PX240801_Pregnancy_History_Family_2_Complication_5
	PX240801020206	Family member #2: Pregnancy complication #5	N/A
PX240801_Pregnancy_History_Family_2_Relation
	PX240801020201	Family member #2: What is his or her family more relation? show less	N/A
PX240801_Pregnancy_History_Family_3_Complication_1
	PX240801020302	Family member #3: Pregnancy complication #1	N/A
PX240801_Pregnancy_History_Family_3_Complication_2
	PX240801020303	Family member #3: Pregnancy complication #2	N/A
PX240801_Pregnancy_History_Family_3_Complication_3
	PX240801020304	Family member #3: Pregnancy complication #3	N/A
PX240801_Pregnancy_History_Family_3_Complication_4
	PX240801020305	Family member #3: Pregnancy complication #4	N/A
PX240801_Pregnancy_History_Family_3_Complication_5
	PX240801020306	Family member #3: Pregnancy complication #5	N/A
PX240801_Pregnancy_History_Family_3_Relation
	PX240801020301	Family member #3: What is his or her family more relation? show less	N/A
PX240801_Pregnancy_History_Family_4_Complication_1
	PX240801020402	Family member #4: Pregnancy complication #1	N/A
PX240801_Pregnancy_History_Family_4_Complication_2
	PX240801020403	Family member #4: Pregnancy complication #2	N/A
PX240801_Pregnancy_History_Family_4_Complication_3
	PX240801020404	Family member #4: Pregnancy complication #3	N/A
PX240801_Pregnancy_History_Family_4_Complication_4
	PX240801020405	Family member #4: Pregnancy complication #4	N/A
PX240801_Pregnancy_History_Family_4_Complication_5
	PX240801020406	Family member #4: Pregnancy complication #5	N/A
PX240801_Pregnancy_History_Family_4_Relation
	PX240801020401	Family member #4: What is his or her family more relation? show less	N/A
PX240801_Pregnancy_History_Family_5_Complication_1
	PX240801020502	Family member #5: Pregnancy complication #1	N/A
PX240801_Pregnancy_History_Family_5_Complication_2
	PX240801020503	Family member #5: Pregnancy complication #2	N/A
PX240801_Pregnancy_History_Family_5_Complication_3
	PX240801020504	Family member #5: Pregnancy complication #3	N/A
PX240801_Pregnancy_History_Family_5_Complication_4
	PX240801020505	Family member #5: Pregnancy complication #4	N/A
PX240801_Pregnancy_History_Family_5_Complication_5
	PX240801020506	Family member #5: Pregnancy complication #5	N/A
PX240801_Pregnancy_History_Family_5_Relation
	PX240801020501	Family member #5: What is his or her family more relation? show less	N/A
PX240801_Pregnancy_History_Low_Amniotic_Fluid
	PX240801010600	Have any of your biological mother, sisters, more half-sisters, or female first cousins ever had the following pregnancy complication? Induction of labor due to low amniotic fluid or poor fetal growth show less	N/A
PX240801_Pregnancy_History_More_Three_Weeks_Premature
	PX240801010100	Have any of your biological mother, sisters, more half-sisters, or female first cousins ever had the following pregnancy complication? Delivery of a child more than 3 weeks before the expected due date show less	N/A
PX240801_Pregnancy_History_Other_Complications
	PX240801010900	Have any of your biological mother, sisters, more half-sisters, or female first cousins ever had the following pregnancy complication? Other pregnancy complication, specify show less	N/A
PX240801_Pregnancy_History_Preeclampsia
	PX240801010500	Have any of your biological mother, sisters, more half-sisters, or female first cousins ever had the following pregnancy complication? Preeclampsia, eclampsia, toxemia, or pregnancy-induced hypertension show less	N/A
PX240801_Pregnancy_History_Preterm_Membrane_Rupture
	PX240801010400	Have any of your biological mother, sisters, more half-sisters, or female first cousins ever had the following pregnancy complication? Early or preterm rupture of the membranes show less	N/A
PX240801_Pregnancy_History_Spontaneous_Preterm_Delivery
	PX240801010300	Have any of your biological mother, sisters, more half-sisters, or female first cousins ever had the following pregnancy complication? Spontaneous preterm delivery (<37 weeks) show less	N/A
PX240801_Pregnancy_History_Stillbirth
	PX240801010700	Have any of your biological mother, sisters, more half-sisters, or female first cousins ever had the following pregnancy complication? Stillbirth show less	N/A
PX240801_Pregnancy_History_Weight_Premature
	PX240801010200	Have any of your biological mother, sisters, more half-sisters, or female first cousins ever had the following pregnancy complication? Delivery of a child weighing less than 5 lb 8 oz (or 2500 grams) show less	N/A

Pregnancy

Measure Name

Family History of Pregnancy Complications

Release Date

January 31, 2017

Definition

Questions to assess a woman’s family history of pregnancy complications

Purpose

Researchers should be knowledgeable about a woman’s family history of pregnancy complications because some complications may be passed from one generation to the next.

Keywords

pregnancy, fertility problems, miscarriage, premature delivery, preterm delivery, premature rupture of membranes, stillbirth, Birth defects, nuMoM2b

Measure Protocols

Protocol ID	Protocol Name
240801	Family History of Pregnancy Complications

Publications

There are no publications listed for this protocol.

Protocol - Family History of Pregnancy Complications

Related Protocols:

Essential Protocols:

Description

Specific Instructions

Availability

Protocol

Personnel and Training Required

Equipment Needs

Requirements

Mode of Administration

Lifestage

Participants

Selection Rationale

Language

Standards

Derived Variables

Process and Review

Protocol Name from Source

Source

General References

Protocol ID

Variables

Measure Name

Release Date

Definition

Purpose

Keywords

Measure Protocols

Publications