Protocol - Cigarette Nicotine Dependence

Description

Measurement of respondent’s symptoms of cigarette dependence.

Specific Instructions

Respondents are asked the cigarette nicotine dependence questions only if they have been classified as a Current Every-Day Smoker, Current Some-Day Smoker, or Former Smoker based on responses to the adolescent and adult Tobacco - Smoking Status protocols. Respondents are asked six categorical questions to assess nicotine dependence. The six questions in this protocol may be asked twice for Current Every-Day and Current Some-Day Smokers: the first time using the current time frame and then a second time if there was a time period when the respondent smoked more than the current amount. During the second round of questions, the time frame is the 6-month period when the respondent was smoking the most. Former Smokers are asked the six questions once; the period of reference is the 6-month period when the respondent was smoking the most.

It should be noted that this measure is not intended to be used for other tobacco products and could be difficult to use with light smokers because cigarettes per day is a key variable.

Availability

Available

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Protocol

The Working Group acknowledges that the following questions may gather sensitive information relating to the use of substances and/or illegal conduct. If the information is released it might be damaging to an individual’s employability, lead to social stigmatization, or other consequences. For information on obtaining a Certificate of Confidentiality, which helps researchers protect the privacy of human research participants, please go to the National Human Genome Research Institute’s Institutional Review Board website. The Working Group modified the questions to ask about current and past behaviors. The interviewer should change the introductory statement, depending on whether they are asking about current or past behaviors and choose the appropriate verb tense.

Current Every-Day or Current Some-Day Smokers: Instructions to interviewer: The following six questions are asked twice: once with the lead-in statement about current usage and, if appropriate, a second time with the lead-in statement about the period of maximum usage. a. Currently,... (ask 6 questions) b. Was there a 6-month period when you smoked more than you do now? (If "Yes," then continue to ask 6 questions again. If "No," stop.)

1. How soon after you wake up do/did you smoke your first cigarette?

1[ ]Within 5 minutes [3 points]

2[ ]6-30 minutes [2 points]

3[ ]31-60 minutes [1 point]

4[ ]After 60 minutes [0 points] 2. Do/Did you find it difficult to refrain from smoking in places where it is forbidden, e.g., in church, at the library, in a cinema, etc.?

1[ ]Yes [1 point]

2[ ]No [0 points]

3. Which cigarette would you hate most to give up?

1[ ]The first one in the morning [1 point]

2[ ]All others [0 points]

4. How many cigarettes per day do/did you smoke?

1[ ]10 or less [0 points]

2[ ]11-20 [1 point]

3[ ]21-30 [2 points]

4[ ]31 or more [3 points]

5. Do/did you smoke more frequently during the first hours after waking than during the rest of the day?

1[ ]Yes [1 point]

2[ ]No [0 points]

6. Do/did you smoke if you are so ill that you are in bed most of the day?

1[ ]Yes [1 point]

2[ ]No [0 points]

Former Smokers: Instructions to interviewer: The following 6 questions are asked about the period of maximum usage. Read the lead-in statement before asking the questions. Think about the six-month period when you were smoking the most... (ask 6 questions)

1. How soon after you wake up did you smoke your first cigarette?

1[ ]Within 5 minutes [3 points]

2[ ]6-30 minutes [2 points]

3[ ]31-60 minutes [1 point]

4[ ]after 60 minutes [0 points]

2. Did you find it difficult to refrain from smoking in places where it is forbidden, e.g., in church, at the library, in a cinema, etc.?

1[ ]Yes [1 point]

2[ ]No [0 points]

3. Which cigarette would you have hated most to give up?

1[ ]The first one in the morning [1 point]

2[ ]All others [0 points]

4. How many cigarettes per day did you smoke?

1[ ]10 or less [0 points]

2[ ]11-20 [1 point]

3[ ]21-30 [2 points]

4[ ]31 or more [3 points]

5. Did you smoke more frequently during the first hours after waking than during the rest of the day?

1[ ]Yes [1 point]

2[ ]No [0 points]

6. Did you smoke when you are so ill that you are in bed most of the day?

1[ ]Yes [1 point]

2[ ]No [0 points]

Note on how to score the results:

Sum the points for each round of 6 questions asked.
The highest score determines lifetime dependence. If the highest score is greater than 4, then the subject meets criteria for lifetime nicotine dependence.

If the score is 4 or more for current smokers who answered the first round of questions ("Currently..."), then the respondent also meets criteria for current dependence.

Personnel and Training Required

Interviewer must be trained and found competent to conduct personal interviews with individuals from the general population. The interviewer should be trained to prompt respondents further if a "don’t know" response is provided.

Equipment Needs

None

Requirements

Requirement Category	Required
Major equipment	No
Specialized training	No
Specialized requirements for biospecimen collection	No
Average time of greater than 15 minutes in an unaffected individual	No

Mode of Administration

Interviewer-administered questionnaire

Lifestage

Adult

Participants

≥17 years old

Selection Rationale

The Fagerstrom Test for Nicotine Dependence has been validated and psychometrically tested and has been widely used in the nicotine research field.

Language

Chinese, English, Other languages available at source

Standards

Standard	Name	ID	Source
Logical Observation Identifiers Names and Codes (LOINC)	Tobac nicotine depend proto	62503-8	LOINC
caDSR Form	PhenX PX031001 - Tobacco Nicotine Dependence	5828404	caDSR Form

Derived Variables

Pack-years: (Tobacco - 30-Day Quantity and Frequency)¹ X (Duration)² The estimation of the components of this calculation can be derived from several PhenX measures. ¹ Tobacco - 30-Day Quantity and Frequency:

Adolescents: Response to question "On the [number of days reported in 2a or 2b] you smoked cigarettes during the past 30 days, how many cigarettes did you smoke per day, on average?"
Adults

Every-day smokers: Response to question "On the average, about how many cigarettes do you now smoke each day?"
Some-day smokers: [(Response to question "On the average, on those days, how many cigarettes did you usually smoke each day?") X (Response to "On how many of the past 30 days did you smoke cigarettes?")] / 30
Former smokers:

Respondents who smoked every day for ≥6 months: Response to question "When you last smoked every day, on average how many cigarettes did you smoke each day?"
Respondents who did not smoke every day for ≥6 months: Response to question "When you last smoked fairly regularly, on average how many cigarettes did you smoke each day?"

The Fagerstrom Test for Nicotine Dependence measure (4. How many cigarettes/day do you smoke?) can also be used to calculate the amount of cigarettes smoked.

Use the midpoint from the response category to obtain the number of cigarettes smoked per day.

² Duration of smoking: (Tobacco - Age of Offset of Cigarette Use³ OR Current age) - (Tobacco - Age of Initiation of First Cigarette Use)⁴ ³ Tobacco - Age of Offset of Cigarette Use:

Adolescents: (Current Age) - (length of time response to the question: "How old were you the last time you smoked part or all of a cigarette?")
Adults: (Current Age) - (length of time response to the question: "About how long has it been since you COMPLETELY quit smoking cigarettes?")

⁴ Tobacco - Age of Initiation of First Cigarette Use:

Adolescents: Age derived from the answer to: 2. "How old were you when you first started smoking cigarettes every day?" OR - For those who never smoked every day, the answer from 1. "How old were you when you first smoked part or all of a cigarette?"

Adults: Age derived from the answer to: 1. "How old were you when you first started smoking cigarettes every day?" OR - For those who never smoked every day, the answer from 2. "How old were you when you first started smoking cigarettes fairly regularly?"

Process and Review

The Expert Review Panel #3 (ERP 3) reviewed the measures in Alcohol, Tobacco and Other Substances, and Substance Abuse and Addiction domains.

Guidance from ERP 3 includes:

• Changed Name of Measure and updated specific instructions to notify users of this measure’s exclusive use to cigarette smokers.

Back-compatible: Partially back-compatible (updated/similar protocol which would require some changes to the data dictionary), variable mapping between current and previous protocols can be found here.

Previous version in Toolkit archive (link)

Protocol Name from Source

Fagerstrom Test for Nicotine Dependence, 1991

Source

Permission to use this scale was obtained from K. O. Fagerstrom (personal communication, January 2009). Heatherton, T. F., Kozlowski, L. T., Frecker, R. C., & Fagerstrom, K. O. (1991). The Fagerstrom Test for Nicotine Dependence: A revision of the Fagerstrom Tolerance Questionnaire. British Journal of Addiction, 86, 1119-1127. Fagerstrom Test for Nicotine Dependence (questions 1-6).

General References

Bierut, L. J., Madden, P. A., Breslau, N., Johnson, E. O., Hatsukami, D., Pomerleau, O. F., Swan, G. E., Rutter, J., Bertelsen, S., Fox, L., Fugman, D., Goate, A. M., Hinrichs, A. L., Konvicka, K., Martin, N. G., Montgomery, G. W., Saccone, N. L., Saccone, S. F., Wang, J. C., Chase, G. A., Rice, J. P., & Ballinger, D. G. (2007). Novel genes identified in a high-density genome wide association study for nicotine dependence. Human Molecular Genetics, 16(1), 24-35.

Protocol ID

31001

Variables

Export Variables

Variable Name	Variable ID	Variable Description	dbGaP Mapping
PX031001_Current_Smoker_1stSmoke_Givingup
	PX031001030000	Current Every-Day or Current Some-Day more Smokers Which cigarette would you hate most to give up? show less	Variable Mapping
PX031001_Current_Smoker_1stSmoke_Time
	PX031001010000	Current Every-Day or Current Some-Day more Smokers How soon after you wake up do/did you smoke your first cigarette? show less	Variable Mapping
PX031001_Current_Smoker_More
	PX031001070000	Was there a 6-month period when you smoked more more than you do now? show less	Variable Mapping
PX031001_Current_Smoker_More_1stHour
	PX031001050000	Current Every-Day or Current Some-Day more Smokers Do/did you smoke more frequently during the first hours after waking than during the rest of the day? show less	Variable Mapping
PX031001_Current_Smoker_More_1stSmoke_Givingup
	PX031001100000	Current Every-Day or Current Some-Day more Smokers Which cigarette would you hate most to give up? show less	Variable Mapping
PX031001_Current_Smoker_More_1stSmoke_Time
	PX031001080000	Current Every-Day or Current Some-Day more Smokers How soon after you wake up do/did you smoke your first cigarette? show less	Variable Mapping
PX031001_Current_Smoker_More_More_1stHour
	PX031001120000	Current Every-Day or Current Some-Day more Smokers Do/did you smoke more frequently during the first hours after waking than during the rest of the day? show less	Variable Mapping
PX031001_Current_Smoker_More_Quantity_1Day
	PX031001110000	Current Every-Day or Current Some-Day more Smokers How many cigarettes per day do/did you smoke? show less	Variable Mapping
PX031001_Current_Smoker_More_Refraining_Difficulty
	PX031001090000	Current Every-Day or Current Some-Day more Smokers Do/Did you find it difficult to refrain from smoking in places where it is forbidden, e.g., in church, at the library, in a cinema, etc.? show less	Variable Mapping
PX031001_Current_Smoker_More_Smoking_During_Illness
	PX031001130000	Current Every-Day or Current Some-Day more Smokers Do/did you smoke if you are so ill that you are in bed most of the day? show less	Variable Mapping
PX031001_Current_Smoker_Quantity_1Day
	PX031001040000	Current Every-Day or Current Some-Day more Smokers How many cigarettes per day do/did you smoke? show less	Variable Mapping
PX031001_Current_Smoker_Refraining_Difficulty
	PX031001020000	Current Every-Day or Current Some-Day more Smokers Do/Did you find it difficult to refrain from smoking in places where it is forbidden, e.g., in church, at the library, in a cinema, etc.? show less	Variable Mapping
PX031001_Current_Smoker_Smoking_During_Illness
	PX031001060000	Current Every-Day or Current Some-Day more Smokers Do/did you smoke if you are so ill that you are in bed most of the day? show less	Variable Mapping
PX031001_Former_Smoker_1stSmoke_Givingup
	PX031001160000	Former Smokers Which cigarette would you more hate most to give up? show less	Variable Mapping
PX031001_Former_Smoker_1stSmoke_Time
	PX031001140000	Former Smokers How soon after you wake up more do/did you smoke your first cigarette? show less	Variable Mapping
PX031001_Former_Smoker_More_1stHour
	PX031001180000	Former Smokers Do/did you smoke more more frequently during the first hours after waking than during the rest of the day? show less	Variable Mapping
PX031001_Former_Smoker_Quantity_1Day
	PX031001170000	Former Smokers How many cigarettes per day more do/did you smoke? show less	Variable Mapping
PX031001_Former_Smoker_Refraining_Difficulty
	PX031001150000	Former Smokers Do/Did you find it difficult more to refrain from smoking in places where it is forbidden, e.g., in church, at the library, in a cinema, etc.? show less	Variable Mapping
PX031001_Former_Smoker_Smoking_During_Illness
	PX031001190000	Former Smokers Do/did you smoke if you are more so ill that you are in bed most of the day? show less	Variable Mapping

Alcohol, Tobacco and Other Substances

Measure Name

Cigarette Nicotine Dependence

Release Date

February 6, 2009

Definition

Questions query respondent on whether s/he has symptoms of nicotine dependence.

Purpose

This measure can be used to assess the participant’s dependence on nicotine.

Keywords

tobacco, smoking, cigarette, nicotine dependence, nicotine, pack years, Fagerstrom Test for Nicotine Dependence, Fagerstrom Tolerance Questionnaire, Fagerstrom, gerontology, aging, geriatrics

Measure Protocols

Protocol ID	Protocol Name
31001	Cigarette Nicotine Dependence

Publications

Klein, E. G., et al. (2024) A Randomized Clinical Trial of a Quitline Vaping Cessation Intervention: Baseline Characteristics of Young Adult Exclusive E-Cigarette Users Seeking Treatment. International Journal of Environmental Research and Public Health. 2024 June; 21(6): 809. doi: 10.3390/ijerph21060809

Kosyluk, K., et al. (2024) Mental Distress, Label Avoidance, and Use of a Mental Health Chatbot: Results From a US Survey. JMIR Formative Research. 2024 April; 8(17). doi: 10.2196/45959

Riley, E. D., et al. (2022) Ongoing tobacco use in women who experience homelessness and unstable housing: A prospective study to inform tobacco cessation interventions and policies. Addictive Behaviors. 2022 February; 125: 107125. doi: 10.1016/j.addbeh.2021.107125

Quach, B. C., et al. (2020) Expanding the genetic architecture of nicotine dependence and its shared genetics with multiple traits. Nature Communications. 2020 November; 11(1): Article Number: 5562. doi: 10.1038/s41467-020-19265-z

Lisdahl, K. M., et al. (2018) Adolescent brain cognitive development (ABCD) study: Overview of substance use assessment methods. Dev Cogn Neurosci. 2018 August; 32: 80-96. doi: 10.1016/j.dcn.2018.02.007

Krebs, N. M., et al. (2016) Comparison of Puff Volume With Cigarettes per Day in Predicting Nicotine Uptake Among Daily Smokers. Am J Epidemiol. 2016 July; 184(1): 48-57. doi: 10.1093/aje/kwv341

Mapping for PX031001_Current_Smoker_1stSmoke_Givingup

dbGAP Study	dbGAP Variable	dbGAP Variable Description
Genetic Epidemiology of COPD (COPDGene)	phv00159638	Which cigarette would you hate most to give up
Genome-Wide Association Study of Schizophrenia	phv00020413	During this period, which one cigarette would you have hated most to give up?
Genome-Wide Association Study of Schizophrenia	phv00034779	During this period, which one cigarette would you have hated most to give up?
Jackson Heart Study (JHS) Cohort	phv00128504	8: Which cigarette hate to give up?
Molecular Genetics of Schizophrenia - nonGAIN Sample (MGS_nonGAIN)	phv00071639	During this period, which one cigarette would you have hated most to give up?
Study of Addiction: Genetics and Environment (SAGE)	phv00066371	Participant's lifetime score for FTND question 3: Which cigarette would you hate most to give up?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162846	Participant's lifetime score for FTND question 3: Which cigarette would you hate most to give up?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162926	Participant's lifetime score for FTND question 3: Which cigarette would you hate most to give up?
Whole Genome Association Study of Bipolar Disorder	phv00035230	During this period, which one cigarette would you have hated most to give up? (Participants with European ancestry)
Whole Genome Association Study of Bipolar Disorder	phv00054538	During this period, which one cigarette would you have hated most to give up? (African American participants)

Mapping for PX031001_Current_Smoker_1stSmoke_Time

dbGAP Study	dbGAP Variable	dbGAP Variable Description
CARDIA Cohort	phv00115559	HOW SOON SMOKE AFTER WAKING. Q 2.09
Genetic Epidemiology of COPD (COPDGene)	phv00159636	How soon after waking do you smoke first cigarette
Genome-Wide Association Study of Schizophrenia	phv00020411	During this time when you smoked the most, how soon after waking did you smoke your first cigarette?
Genome-Wide Association Study of Schizophrenia	phv00034777	During this time when you smoked the most, how soon after waking did you smoke your first cigarette?
GWAS on Cataract and HDL in the PMRP	phv00181750	Current Every-Day or Current Some-Day Smokers Question 1 - How soon after you wake up do/did you smoke your first cigarette?
GWAS on Cataract and HDL in the PMRP	phv00181762	Current Every-Day or Current Some-Day Smokers (Maximum use-for those that said yes to: was there a 6 month period when you smoked more) Question 1 - How soon after you wake up do/did you smoke your first cigarette?
Molecular Genetics of Schizophrenia - nonGAIN Sample (MGS_nonGAIN)	phv00071637	During this time when you smoked the most, how soon after waking did you smoke your first cigarette?
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00175431	TIME FROM WAKING UP TO SMOKING FIRST MORNING CIGARETTE
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00176865	TIME FROM WAKING UP TO SMOKING FIRST MORNING CIGARETTE
Study of Addiction: Genetics and Environment (SAGE)	phv00066369	Participant's lifetime score for Fagerstr????m Test for Nicotine Dependence (FTND) question 1: How soon after waking do you smoke your first cigarette?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162844	Participant's lifetime score for Fagerstr????m Test for Nicotine Dependence (FTND) question 1: How soon after waking do you smoke your first cigarette?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162924	Participant's lifetime score for Fagerstr????m Test for Nicotine Dependence (FTND) question 1: How soon after waking do you smoke your first cigarette?
Whole Genome Association Study of Bipolar Disorder	phv00015796	J4. Mins after Waking Smoke, (Participants with European ancestry). DIGS3
Whole Genome Association Study of Bipolar Disorder	phv00035228	During this time when you smoked the most, how soon after waking did you smoke your first cigarette? (Participants with European ancestry)
Whole Genome Association Study of Bipolar Disorder	phv00054536	During this time when you smoked the most, how soon after waking did you smoke your first cigarette? (African American participants)

Mapping for PX031001_Current_Smoker_More

dbGAP Study	dbGAP Variable	dbGAP Variable Description
GWAS on Cataract and HDL in the PMRP	phv00181768	Was there a 6 month period when you smoked more than you do now? If yes {Return to 11 and answer for MAXIMUM Use - not for data entry} If No go to question 23

Mapping for PX031001_Current_Smoker_More_1stHour

dbGAP Study	dbGAP Variable	dbGAP Variable Description
Genetic Epidemiology of COPD (COPDGene)	phv00159637	Smoke more during first 2 hours of day than rest of day
Genome-Wide Association Study of Schizophrenia	phv00020414	During this period, did you smoke more frequently during the first hours after waking than during the rest of the day?
Genome-Wide Association Study of Schizophrenia	phv00034780	During this period, did you smoke more frequently during the first hours after waking than during the rest of the day?
Jackson Heart Study (JHS) Cohort	phv00128502	6: Smoke more first few hrs after wake
Molecular Genetics of Schizophrenia - nonGAIN Sample (MGS_nonGAIN)	phv00071640	During this period, did you smoke more frequently during the first hours after waking than during the rest of the day?
Study of Addiction: Genetics and Environment (SAGE)	phv00066373	Participant's lifetime score for FTND question 5: Do you smoke more frequently during the first hours after waking than during the rest of the day?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162848	Participant's lifetime score for FTND question 5: Do you smoke more frequently during the first hours after waking than during the rest of the day?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162928	Participant's lifetime score for FTND question 5: Do you smoke more frequently during the first hours after waking than during the rest of the day?
Whole Genome Association Study of Bipolar Disorder	phv00015797	J5. Smoke More First Thing, (Participants with European ancestry). DIGS3
Whole Genome Association Study of Bipolar Disorder	phv00018288	J5. Smoke more after waking. (Participants with European ancestry). DIGS4
Whole Genome Association Study of Bipolar Disorder	phv00035231	During this period, did you smoke more frequently during the first hours after waking than during the rest of the day? (Participants with European ancestry)
Whole Genome Association Study of Bipolar Disorder	phv00054539	During this period, did you smoke more frequently during the first hours after waking than during the rest of the day? (African American participants)

Mapping for PX031001_Current_Smoker_More_1stSmoke_Givingup

dbGAP Study	dbGAP Variable	dbGAP Variable Description
Genetic Epidemiology of COPD (COPDGene)	phv00159638	Which cigarette would you hate most to give up
Genome-Wide Association Study of Schizophrenia	phv00020413	During this period, which one cigarette would you have hated most to give up?
Genome-Wide Association Study of Schizophrenia	phv00034779	During this period, which one cigarette would you have hated most to give up?
Jackson Heart Study (JHS) Cohort	phv00128504	8: Which cigarette hate to give up?
Molecular Genetics of Schizophrenia - nonGAIN Sample (MGS_nonGAIN)	phv00071639	During this period, which one cigarette would you have hated most to give up?
Study of Addiction: Genetics and Environment (SAGE)	phv00066371	Participant's lifetime score for FTND question 3: Which cigarette would you hate most to give up?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162846	Participant's lifetime score for FTND question 3: Which cigarette would you hate most to give up?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162926	Participant's lifetime score for FTND question 3: Which cigarette would you hate most to give up?
Whole Genome Association Study of Bipolar Disorder	phv00035230	During this period, which one cigarette would you have hated most to give up? (Participants with European ancestry)
Whole Genome Association Study of Bipolar Disorder	phv00054538	During this period, which one cigarette would you have hated most to give up? (African American participants)

Mapping for PX031001_Current_Smoker_More_1stSmoke_Time

dbGAP Study	dbGAP Variable	dbGAP Variable Description
CARDIA Cohort	phv00115559	HOW SOON SMOKE AFTER WAKING. Q 2.09
Genetic Epidemiology of COPD (COPDGene)	phv00159636	How soon after waking do you smoke first cigarette
Genome-Wide Association Study of Schizophrenia	phv00020411	During this time when you smoked the most, how soon after waking did you smoke your first cigarette?
Genome-Wide Association Study of Schizophrenia	phv00034777	During this time when you smoked the most, how soon after waking did you smoke your first cigarette?
GWAS on Cataract and HDL in the PMRP	phv00181750	Current Every-Day or Current Some-Day Smokers Question 1 - How soon after you wake up do/did you smoke your first cigarette?
GWAS on Cataract and HDL in the PMRP	phv00181762	Current Every-Day or Current Some-Day Smokers (Maximum use-for those that said yes to: was there a 6 month period when you smoked more) Question 1 - How soon after you wake up do/did you smoke your first cigarette?
Molecular Genetics of Schizophrenia - nonGAIN Sample (MGS_nonGAIN)	phv00071637	During this time when you smoked the most, how soon after waking did you smoke your first cigarette?
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00175431	TIME FROM WAKING UP TO SMOKING FIRST MORNING CIGARETTE
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00176865	TIME FROM WAKING UP TO SMOKING FIRST MORNING CIGARETTE
Study of Addiction: Genetics and Environment (SAGE)	phv00066369	Participant's lifetime score for Fagerstr????m Test for Nicotine Dependence (FTND) question 1: How soon after waking do you smoke your first cigarette?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162844	Participant's lifetime score for Fagerstr????m Test for Nicotine Dependence (FTND) question 1: How soon after waking do you smoke your first cigarette?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162924	Participant's lifetime score for Fagerstr????m Test for Nicotine Dependence (FTND) question 1: How soon after waking do you smoke your first cigarette?
Whole Genome Association Study of Bipolar Disorder	phv00015796	J4. Mins after Waking Smoke, (Participants with European ancestry). DIGS3
Whole Genome Association Study of Bipolar Disorder	phv00035228	During this time when you smoked the most, how soon after waking did you smoke your first cigarette? (Participants with European ancestry)
Whole Genome Association Study of Bipolar Disorder	phv00054536	During this time when you smoked the most, how soon after waking did you smoke your first cigarette? (African American participants)

Mapping for PX031001_Current_Smoker_More_More_1stHour

dbGAP Study	dbGAP Variable	dbGAP Variable Description
Genetic Epidemiology of COPD (COPDGene)	phv00159637	Smoke more during first 2 hours of day than rest of day
Genome-Wide Association Study of Schizophrenia	phv00020414	During this period, did you smoke more frequently during the first hours after waking than during the rest of the day?
Genome-Wide Association Study of Schizophrenia	phv00034780	During this period, did you smoke more frequently during the first hours after waking than during the rest of the day?
Jackson Heart Study (JHS) Cohort	phv00128502	6: Smoke more first few hrs after wake
Molecular Genetics of Schizophrenia - nonGAIN Sample (MGS_nonGAIN)	phv00071640	During this period, did you smoke more frequently during the first hours after waking than during the rest of the day?
Study of Addiction: Genetics and Environment (SAGE)	phv00066373	Participant's lifetime score for FTND question 5: Do you smoke more frequently during the first hours after waking than during the rest of the day?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162848	Participant's lifetime score for FTND question 5: Do you smoke more frequently during the first hours after waking than during the rest of the day?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162928	Participant's lifetime score for FTND question 5: Do you smoke more frequently during the first hours after waking than during the rest of the day?
Whole Genome Association Study of Bipolar Disorder	phv00015797	J5. Smoke More First Thing, (Participants with European ancestry). DIGS3
Whole Genome Association Study of Bipolar Disorder	phv00018288	J5. Smoke more after waking. (Participants with European ancestry). DIGS4
Whole Genome Association Study of Bipolar Disorder	phv00035231	During this period, did you smoke more frequently during the first hours after waking than during the rest of the day? (Participants with European ancestry)
Whole Genome Association Study of Bipolar Disorder	phv00054539	During this period, did you smoke more frequently during the first hours after waking than during the rest of the day? (African American participants)

Mapping for PX031001_Current_Smoker_More_Quantity_1Day

dbGAP Study	dbGAP Variable	dbGAP Variable Description
Atherosclerosis Risk in Communities (ARIC) Cohort	phv00214122	If yes to [SMKNOW15]: How many cigarettes do you smoke per day now?
Atherosclerosis Risk in Communities (ARIC) Cohort	phv00209086	[Smoking]. How many cigarettes do you usually smoke per day now? Q11 [Personal History form, exam 4]
Atherosclerosis Risk in Communities (ARIC) Cohort	phv00209085	[Smoking]. Prior to quitting, how many cigarettes did you usually smoke per day? Q10 [Personal History form, exam 4]
Atherosclerosis Risk in Communities (ARIC) Cohort	phv00209026	[Smoking]. How many cigarettes do you smoke per day now? Q30 [Personal History Form, exam 3]
Atherosclerosis Risk in Communities (ARIC) Cohort	phv00207375	On the average of the entire time you smoked, how many cigarettes did you usually smoke per day? Q35 [Home Interview, exam 1]
Atherosclerosis Risk in Communities (ARIC) Cohort	phv00207123	[Smoking]. How many cigarettes do you smoke per day now? [Code 00 if less than one per day]. Q48 [Health/Medical History, exam 2]
Cardiovascular Health Study (CHS) Cohort	phv00198830	24 average number of cigarettes/day
Cardiovascular Health Study (CHS) Cohort	phv00197482	How many cigarettes per day did you average over all the time you smoked?
Cardiovascular Health Study (CHS) Cohort	phv00197481	If yes to [SMKNOW15]: How many cigarettes do you smoke per day now?
Framingham Cohort	phv00004274	HOW MANY CIGARETTES DO/DID YOU SMOKE PER DAY?
Framingham Cohort	phv00177305	Medical History-Smoking: Question refers to 'whole lifetime'. On the average of the entire time you smoked, how many cigarettes did you smoke per day?
Framingham Cohort	phv00177304	Medical History-Smoking: How many cigarettes do you smoke per day now?
Framingham Cohort	phv00072092	ON AVERAGE, SINCE YOUR LAST EXAM, HOW MANY CIGARETTES DID YOU SMOKE PER DAY?
Framingham Cohort	phv00072091	HOW MANY CIGARETTES DO YOU SMOKE PER DAY NOW?
Framingham Cohort	phv00056745	On average, during the entire time you smoked, how many cigarettes did you usually smoke per day?
Framingham Cohort	phv00055319	If yes to [SMKNOW15]: How many cigarettes do you smoke per day now?
Framingham Cohort	phv00003831	HOW MANY CIGARETTES DO/DID YOU SMOKE PER DAY
Framingham Cohort	phv00005034	CIGARETTES - HOW MANY CIGARETTES DO/DID YOU SMOKE PER DAY?
Framingham Cohort	phv00006180	IF YES (TO FQ194), HOW MANY CIGARETTES DO/DID YOU SMOKE A DAY?
Framingham Cohort	phv00006526	SMOKING HISTORY HOW MANY CIGARETTES DO/DID YOU SMOKE A DAY?
Framingham Cohort	phv00006957	SMOKING: HOW MANY CIGARETTES DO/DID YOU SMOKE A DAY?
Framingham Cohort	phv00007389	SMOKING: HOW MANY CIGARETTES DO/DID YOU SMOKE A DAY?
Framingham Cohort	phv00008863	HOW MANY CIGARETTES DO/DID YOU SMOKE PER DAY
Framingham Cohort	phv00020929	IF EVER SMOKED CIGS REGULARLY: ON THE AVERAGE OF THE ENTIRE TIME YOU SMOKED, HOW MANY CIGARETTES DID YOU SMOKE PER DAY?
Framingham Cohort	phv00009779	HOW MANY CIGARETTES DO/DID YOU SMOKE A DAY
Framingham Cohort	phv00010260	HOW MANY CIGARETTES DO/DID YOU SMOKE A DAY
Framingham Cohort	phv00010668	RESPIRATORY: HOW MANY CIGARETTES DO/DID YOU SMOKE A DAY?
Genetic Epidemiology of COPD (COPDGene)	phv00159750	How many cigarettes do you smoke per day now? [Cigarettes/day]
Genetic Epidemiology of COPD (COPDGene)	phv00159766	How many cigars do you smoke per day now. [Cigars per day]
Genetic Epidemiology of COPD (COPDGene)	phv00159762	On average ounces of tobacco smoked per week [oz per week]
Genetic Epidemiology of COPD (COPDGene)	phv00159752	Average for entire time how many cigarettes smoked per day [cigarettes/day]
GENEVA Genetics of Early Onset Stroke (GEOS) Study	phv00111939	For current smokers, the average number of packs smoked per day (1 pack=20 cigarettes)
Genome-Wide Association Study of Schizophrenia	phv00034783	How many cigarettes do you smoke in a typical day?
Genome-Wide Association Study of Schizophrenia	phv00034776	How many cigarettes did you smoke on a typical day?
Genome-Wide Association Study of Schizophrenia	phv00020410	How many cigarettes did you smoke on a typical day?
Genome-Wide Association Study of Schizophrenia	phv00020417	How many cigarettes do you smoke in a typical day?
GWAS on Cataract and HDL in the PMRP	phv00181740	Protocol A is used with adults who are Every-Day Smokers. On the average, about how many cigarettes do you now smoke each day?
GWAS on Cataract and HDL in the PMRP	phv00181753	Current Every-Day or Current Some-Day Smokers Question 4 - How many cigarettes per day do/did you smoke
HMP Core Microbiome Sampling Protocol A (HMP-A)	phv00158620	Frequency of cigarette
HMP Core Microbiome Sampling Protocol A (HMP-A)	phv00158621	Frequency of cigarette - coded fields
Molecular Genetics of Schizophrenia - nonGAIN Sample (MGS_nonGAIN)	phv00071643	How many cigarettes do you smoke in a typical day?
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00086582	CIGARETTES: AVERAGE
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00085574	CIGARETTES: AVERAGE
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00176867	AVERAGE CIGARETTES SMOKED PER DAY
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00175433	AVERAGE CIGARETTES SMOKED PER DAY
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00083247	CIGARETTES: AVERAGE
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00086098	CIGARETTES: AVERAGE
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00087014	AVERAGE CIGARETTES SMOKED PER DAY
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00087256	AVERAGE NUMBER OF CIGARETTES SMOKED PER DAY
NEI Age-Related Eye Disease Study (AREDS)	phv00053865	HOW MANY CIGARETTES A DAY SMOKE (ALL PARTICIPANTS)
NEI Age-Related Eye Disease Study (AREDS)	phv00053992	HOW MANY CIGARETTES PER DAY SMOKE (ALL PARTICIPANTS)
NEI Age-Related Eye Disease Study (AREDS)	phv00053990	AVERAGE PACKS PER DAY SMOKED (ALL PARTICIPANTS)
NEI Age-Related Eye Disease Study (AREDS)	phv00053863	AVERAGE PACKS PER DAY SMOKED (ALL PARTICIPANTS)
NHLBI Cleveland Family Study (CFS) Candidate Gene Association Resource (CARe)	phv00123027	Smoking: Average packs smoked/year
NHLBI Cleveland Family Study (CFS) Candidate Gene Association Resource (CARe)	phv00122546	Average number of cigarettes smoked/day (C)
NHLBI Cleveland Family Study (CFS) Candidate Gene Association Resource (CARe)	phv00122342	Average number of cigarettes smoke per day (A)
NIA Long Life Family Study (LLFS)	phv00163301	Average Number of Cigarettes Usually Smoke(d) Per Day
Study of Addiction: Genetics and Environment (SAGE)	phv00066372	Participant's lifetime score for FTND question 4: How many cigarettes/day do you smoke?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162927	Participant's lifetime score for FTND question 4: How many cigarettes/day do you smoke?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162847	Participant's lifetime score for FTND question 4: How many cigarettes/day do you smoke?
The Genomics and Randomized Trials Network (GARNET) Vitamin Intervention Stroke Prevention (VISP) trial	phv00180534	How many cigarettes do you usually smoke per day?
The Genomics and Randomized Trials Network (GARNET) Vitamin Intervention Stroke Prevention (VISP) trial	phv00179639	How many cigarettes do you smoke per day?
The Vaginal Microbiome: Disease, Genetics and the Environment	phv00090475	During the last 30 days, on average, how many cigarettes have you smoked per day?

Mapping for PX031001_Current_Smoker_More_Refraining_Difficulty

dbGAP Study	dbGAP Variable	dbGAP Variable Description
Genetic Epidemiology of COPD (COPDGene)	phv00159639	Do you find it hard to not smoke in forbidden places
Genome-Wide Association Study of Schizophrenia	phv00020412	Did you find it difficult to refrain from smoking in places where it is forbidden, e.g., in church, at the library, in the cinema, etc.?
Genome-Wide Association Study of Schizophrenia	phv00034778	Did you find it difficult to refrain from smoking in places where it is forbidden, e.g., in church, at the library, in the cinema, etc.?
Molecular Genetics of Schizophrenia - nonGAIN Sample (MGS_nonGAIN)	phv00071638	Did you find it difficult to refrain from smoking in places where it is forbidden, e.g., in church, at the library, in the cinema, etc.?
Study of Addiction: Genetics and Environment (SAGE)	phv00066370	Participant's lifetime score for FTND question 2: Do you find it difficult to refrain from smoking in places where it is forbidden?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162845	Participant's lifetime score for FTND question 2: Do you find it difficult to refrain from smoking in places where it is forbidden?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162925	Participant's lifetime score for FTND question 2: Do you find it difficult to refrain from smoking in places where it is forbidden?
Whole Genome Association Study of Bipolar Disorder	phv00018290	J6. Forbidden places. (Participants with European ancestry). DIGS4
Whole Genome Association Study of Bipolar Disorder	phv00035229	Did you find it difficult to refrain from smoking in places where it is forbidden, e.g., in church, at the library, in the cinema, etc.? (Participants with European ancestry)
Whole Genome Association Study of Bipolar Disorder	phv00052658	J6 Forbidden places, (African American participants). DIGS4
Whole Genome Association Study of Bipolar Disorder	phv00054537	Did you find it difficult to refrain from smoking in places where it is forbidden, e.g., in church, at the library, in the cinema, etc.? (African American participants)

Mapping for PX031001_Current_Smoker_More_Smoking_During_Illness

dbGAP Study	dbGAP Variable	dbGAP Variable Description
Genetic Epidemiology of COPD (COPDGene)	phv00159640	Smoke when so ill you are in bed most of day
Genome-Wide Association Study of Schizophrenia	phv00020415	During this period, did you smoke if you are so ill that you are in bed most of the day?
Genome-Wide Association Study of Schizophrenia	phv00034781	During this period, did you smoke if you are so ill that you are in bed most of the day?
GWAS on Cataract and HDL in the PMRP	phv00181755	Current Every-Day or Current Some-Day Smokers Question 6 - Do/did you smoke if you are so ill that you are in bed most of the day?
GWAS on Cataract and HDL in the PMRP	phv00181767	Current Every-Day or Current Some-Day Smokers (Maximum use-for those that said yes to: was there a 6 month period when you smoked more) Question 6 - Do/did you smoke if you are so ill that you are in bed most of the day?
Jackson Heart Study (JHS) Cohort	phv00128506	10: Smoke when ill?
Molecular Genetics of Schizophrenia - nonGAIN Sample (MGS_nonGAIN)	phv00071641	During this period, did you smoke if you are so ill that you are in bed most of the day?
Study of Addiction: Genetics and Environment (SAGE)	phv00066374	Participant's lifetime score for FTND question 6: Do you smoke when you are so ill that you are in bed most of the day?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162849	Participant's lifetime score for FTND question 6: Do you smoke when you are so ill that you are in bed most of the day?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162929	Participant's lifetime score for FTND question 6: Do you smoke when you are so ill that you are in bed most of the day?
Whole Genome Association Study of Bipolar Disorder	phv00015800	J8. Smoked While Ill in Bed, (Participants with European ancestry). DIGS3
Whole Genome Association Study of Bipolar Disorder	phv00015858	J19. Smoke w Serious Ill Spec, (Participants with European ancestry). DIGS3
Whole Genome Association Study of Bipolar Disorder	phv00018294	J8. Smoked even when ill. (Participants with European ancestry). DIGS4
Whole Genome Association Study of Bipolar Disorder	phv00035232	During this period, did you smoke if you are so ill that you are in bed most of the day? (Participants with European ancestry)
Whole Genome Association Study of Bipolar Disorder	phv00052660	J8 Smoked even when ill, (African American participants). DIGS4
Whole Genome Association Study of Bipolar Disorder	phv00054540	During this period, did you smoke if you are so ill that you are in bed most of the day? (African American participants)

Mapping for PX031001_Current_Smoker_Quantity_1Day

dbGAP Study	dbGAP Variable	dbGAP Variable Description
Atherosclerosis Risk in Communities (ARIC) Cohort	phv00214122	If yes to [SMKNOW15]: How many cigarettes do you smoke per day now?
Atherosclerosis Risk in Communities (ARIC) Cohort	phv00209086	[Smoking]. How many cigarettes do you usually smoke per day now? Q11 [Personal History form, exam 4]
Atherosclerosis Risk in Communities (ARIC) Cohort	phv00209085	[Smoking]. Prior to quitting, how many cigarettes did you usually smoke per day? Q10 [Personal History form, exam 4]
Atherosclerosis Risk in Communities (ARIC) Cohort	phv00209026	[Smoking]. How many cigarettes do you smoke per day now? Q30 [Personal History Form, exam 3]
Atherosclerosis Risk in Communities (ARIC) Cohort	phv00207375	On the average of the entire time you smoked, how many cigarettes did you usually smoke per day? Q35 [Home Interview, exam 1]
Atherosclerosis Risk in Communities (ARIC) Cohort	phv00207123	[Smoking]. How many cigarettes do you smoke per day now? [Code 00 if less than one per day]. Q48 [Health/Medical History, exam 2]
Cardiovascular Health Study (CHS) Cohort	phv00198830	24 average number of cigarettes/day
Cardiovascular Health Study (CHS) Cohort	phv00197482	How many cigarettes per day did you average over all the time you smoked?
Cardiovascular Health Study (CHS) Cohort	phv00197481	If yes to [SMKNOW15]: How many cigarettes do you smoke per day now?
Framingham Cohort	phv00004274	HOW MANY CIGARETTES DO/DID YOU SMOKE PER DAY?
Framingham Cohort	phv00177305	Medical History-Smoking: Question refers to 'whole lifetime'. On the average of the entire time you smoked, how many cigarettes did you smoke per day?
Framingham Cohort	phv00177304	Medical History-Smoking: How many cigarettes do you smoke per day now?
Framingham Cohort	phv00072092	ON AVERAGE, SINCE YOUR LAST EXAM, HOW MANY CIGARETTES DID YOU SMOKE PER DAY?
Framingham Cohort	phv00072091	HOW MANY CIGARETTES DO YOU SMOKE PER DAY NOW?
Framingham Cohort	phv00056745	On average, during the entire time you smoked, how many cigarettes did you usually smoke per day?
Framingham Cohort	phv00055319	If yes to [SMKNOW15]: How many cigarettes do you smoke per day now?
Framingham Cohort	phv00003831	HOW MANY CIGARETTES DO/DID YOU SMOKE PER DAY
Framingham Cohort	phv00005034	CIGARETTES - HOW MANY CIGARETTES DO/DID YOU SMOKE PER DAY?
Framingham Cohort	phv00006180	IF YES (TO FQ194), HOW MANY CIGARETTES DO/DID YOU SMOKE A DAY?
Framingham Cohort	phv00006526	SMOKING HISTORY HOW MANY CIGARETTES DO/DID YOU SMOKE A DAY?
Framingham Cohort	phv00006957	SMOKING: HOW MANY CIGARETTES DO/DID YOU SMOKE A DAY?
Framingham Cohort	phv00007389	SMOKING: HOW MANY CIGARETTES DO/DID YOU SMOKE A DAY?
Framingham Cohort	phv00008863	HOW MANY CIGARETTES DO/DID YOU SMOKE PER DAY
Framingham Cohort	phv00020929	IF EVER SMOKED CIGS REGULARLY: ON THE AVERAGE OF THE ENTIRE TIME YOU SMOKED, HOW MANY CIGARETTES DID YOU SMOKE PER DAY?
Framingham Cohort	phv00009779	HOW MANY CIGARETTES DO/DID YOU SMOKE A DAY
Framingham Cohort	phv00010260	HOW MANY CIGARETTES DO/DID YOU SMOKE A DAY
Framingham Cohort	phv00010668	RESPIRATORY: HOW MANY CIGARETTES DO/DID YOU SMOKE A DAY?
Genetic Epidemiology of COPD (COPDGene)	phv00159750	How many cigarettes do you smoke per day now? [Cigarettes/day]
Genetic Epidemiology of COPD (COPDGene)	phv00159766	How many cigars do you smoke per day now. [Cigars per day]
Genetic Epidemiology of COPD (COPDGene)	phv00159762	On average ounces of tobacco smoked per week [oz per week]
Genetic Epidemiology of COPD (COPDGene)	phv00159752	Average for entire time how many cigarettes smoked per day [cigarettes/day]
GENEVA Genetics of Early Onset Stroke (GEOS) Study	phv00111939	For current smokers, the average number of packs smoked per day (1 pack=20 cigarettes)
Genome-Wide Association Study of Schizophrenia	phv00034783	How many cigarettes do you smoke in a typical day?
Genome-Wide Association Study of Schizophrenia	phv00034776	How many cigarettes did you smoke on a typical day?
Genome-Wide Association Study of Schizophrenia	phv00020410	How many cigarettes did you smoke on a typical day?
Genome-Wide Association Study of Schizophrenia	phv00020417	How many cigarettes do you smoke in a typical day?
GWAS on Cataract and HDL in the PMRP	phv00181740	Protocol A is used with adults who are Every-Day Smokers. On the average, about how many cigarettes do you now smoke each day?
GWAS on Cataract and HDL in the PMRP	phv00181753	Current Every-Day or Current Some-Day Smokers Question 4 - How many cigarettes per day do/did you smoke
HMP Core Microbiome Sampling Protocol A (HMP-A)	phv00158620	Frequency of cigarette
HMP Core Microbiome Sampling Protocol A (HMP-A)	phv00158621	Frequency of cigarette - coded fields
Molecular Genetics of Schizophrenia - nonGAIN Sample (MGS_nonGAIN)	phv00071643	How many cigarettes do you smoke in a typical day?
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00086582	CIGARETTES: AVERAGE
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00085574	CIGARETTES: AVERAGE
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00176867	AVERAGE CIGARETTES SMOKED PER DAY
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00175433	AVERAGE CIGARETTES SMOKED PER DAY
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00083247	CIGARETTES: AVERAGE
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00086098	CIGARETTES: AVERAGE
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00087014	AVERAGE CIGARETTES SMOKED PER DAY
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00087256	AVERAGE NUMBER OF CIGARETTES SMOKED PER DAY
NEI Age-Related Eye Disease Study (AREDS)	phv00053865	HOW MANY CIGARETTES A DAY SMOKE (ALL PARTICIPANTS)
NEI Age-Related Eye Disease Study (AREDS)	phv00053992	HOW MANY CIGARETTES PER DAY SMOKE (ALL PARTICIPANTS)
NEI Age-Related Eye Disease Study (AREDS)	phv00053990	AVERAGE PACKS PER DAY SMOKED (ALL PARTICIPANTS)
NEI Age-Related Eye Disease Study (AREDS)	phv00053863	AVERAGE PACKS PER DAY SMOKED (ALL PARTICIPANTS)
NHLBI Cleveland Family Study (CFS) Candidate Gene Association Resource (CARe)	phv00123027	Smoking: Average packs smoked/year
NHLBI Cleveland Family Study (CFS) Candidate Gene Association Resource (CARe)	phv00122546	Average number of cigarettes smoked/day (C)
NHLBI Cleveland Family Study (CFS) Candidate Gene Association Resource (CARe)	phv00122342	Average number of cigarettes smoke per day (A)
NIA Long Life Family Study (LLFS)	phv00163301	Average Number of Cigarettes Usually Smoke(d) Per Day
Study of Addiction: Genetics and Environment (SAGE)	phv00066372	Participant's lifetime score for FTND question 4: How many cigarettes/day do you smoke?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162927	Participant's lifetime score for FTND question 4: How many cigarettes/day do you smoke?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162847	Participant's lifetime score for FTND question 4: How many cigarettes/day do you smoke?
The Genomics and Randomized Trials Network (GARNET) Vitamin Intervention Stroke Prevention (VISP) trial	phv00180534	How many cigarettes do you usually smoke per day?
The Genomics and Randomized Trials Network (GARNET) Vitamin Intervention Stroke Prevention (VISP) trial	phv00179639	How many cigarettes do you smoke per day?
The Vaginal Microbiome: Disease, Genetics and the Environment	phv00090475	During the last 30 days, on average, how many cigarettes have you smoked per day?

Mapping for PX031001_Current_Smoker_Refraining_Difficulty

dbGAP Study	dbGAP Variable	dbGAP Variable Description
Genetic Epidemiology of COPD (COPDGene)	phv00159639	Do you find it hard to not smoke in forbidden places
Genome-Wide Association Study of Schizophrenia	phv00020412	Did you find it difficult to refrain from smoking in places where it is forbidden, e.g., in church, at the library, in the cinema, etc.?
Genome-Wide Association Study of Schizophrenia	phv00034778	Did you find it difficult to refrain from smoking in places where it is forbidden, e.g., in church, at the library, in the cinema, etc.?
Molecular Genetics of Schizophrenia - nonGAIN Sample (MGS_nonGAIN)	phv00071638	Did you find it difficult to refrain from smoking in places where it is forbidden, e.g., in church, at the library, in the cinema, etc.?
Study of Addiction: Genetics and Environment (SAGE)	phv00066370	Participant's lifetime score for FTND question 2: Do you find it difficult to refrain from smoking in places where it is forbidden?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162845	Participant's lifetime score for FTND question 2: Do you find it difficult to refrain from smoking in places where it is forbidden?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162925	Participant's lifetime score for FTND question 2: Do you find it difficult to refrain from smoking in places where it is forbidden?
Whole Genome Association Study of Bipolar Disorder	phv00018290	J6. Forbidden places. (Participants with European ancestry). DIGS4
Whole Genome Association Study of Bipolar Disorder	phv00035229	Did you find it difficult to refrain from smoking in places where it is forbidden, e.g., in church, at the library, in the cinema, etc.? (Participants with European ancestry)
Whole Genome Association Study of Bipolar Disorder	phv00052658	J6 Forbidden places, (African American participants). DIGS4
Whole Genome Association Study of Bipolar Disorder	phv00054537	Did you find it difficult to refrain from smoking in places where it is forbidden, e.g., in church, at the library, in the cinema, etc.? (African American participants)

Mapping for PX031001_Current_Smoker_Smoking_During_Illness

dbGAP Study	dbGAP Variable	dbGAP Variable Description
Genetic Epidemiology of COPD (COPDGene)	phv00159640	Smoke when so ill you are in bed most of day
Genome-Wide Association Study of Schizophrenia	phv00020415	During this period, did you smoke if you are so ill that you are in bed most of the day?
Genome-Wide Association Study of Schizophrenia	phv00034781	During this period, did you smoke if you are so ill that you are in bed most of the day?
GWAS on Cataract and HDL in the PMRP	phv00181755	Current Every-Day or Current Some-Day Smokers Question 6 - Do/did you smoke if you are so ill that you are in bed most of the day?
GWAS on Cataract and HDL in the PMRP	phv00181767	Current Every-Day or Current Some-Day Smokers (Maximum use-for those that said yes to: was there a 6 month period when you smoked more) Question 6 - Do/did you smoke if you are so ill that you are in bed most of the day?
Jackson Heart Study (JHS) Cohort	phv00128506	10: Smoke when ill?
Molecular Genetics of Schizophrenia - nonGAIN Sample (MGS_nonGAIN)	phv00071641	During this period, did you smoke if you are so ill that you are in bed most of the day?
Study of Addiction: Genetics and Environment (SAGE)	phv00066374	Participant's lifetime score for FTND question 6: Do you smoke when you are so ill that you are in bed most of the day?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162849	Participant's lifetime score for FTND question 6: Do you smoke when you are so ill that you are in bed most of the day?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162929	Participant's lifetime score for FTND question 6: Do you smoke when you are so ill that you are in bed most of the day?
Whole Genome Association Study of Bipolar Disorder	phv00015800	J8. Smoked While Ill in Bed, (Participants with European ancestry). DIGS3
Whole Genome Association Study of Bipolar Disorder	phv00015858	J19. Smoke w Serious Ill Spec, (Participants with European ancestry). DIGS3
Whole Genome Association Study of Bipolar Disorder	phv00018294	J8. Smoked even when ill. (Participants with European ancestry). DIGS4
Whole Genome Association Study of Bipolar Disorder	phv00035232	During this period, did you smoke if you are so ill that you are in bed most of the day? (Participants with European ancestry)
Whole Genome Association Study of Bipolar Disorder	phv00052660	J8 Smoked even when ill, (African American participants). DIGS4
Whole Genome Association Study of Bipolar Disorder	phv00054540	During this period, did you smoke if you are so ill that you are in bed most of the day? (African American participants)

Mapping for PX031001_Former_Smoker_1stSmoke_Givingup

dbGAP Study	dbGAP Variable	dbGAP Variable Description
Genetic Epidemiology of COPD (COPDGene)	phv00159638	Which cigarette would you hate most to give up
Genome-Wide Association Study of Schizophrenia	phv00020413	During this period, which one cigarette would you have hated most to give up?
Genome-Wide Association Study of Schizophrenia	phv00034779	During this period, which one cigarette would you have hated most to give up?
Jackson Heart Study (JHS) Cohort	phv00128504	8: Which cigarette hate to give up?
Molecular Genetics of Schizophrenia - nonGAIN Sample (MGS_nonGAIN)	phv00071639	During this period, which one cigarette would you have hated most to give up?
Study of Addiction: Genetics and Environment (SAGE)	phv00066371	Participant's lifetime score for FTND question 3: Which cigarette would you hate most to give up?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162846	Participant's lifetime score for FTND question 3: Which cigarette would you hate most to give up?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162926	Participant's lifetime score for FTND question 3: Which cigarette would you hate most to give up?
Whole Genome Association Study of Bipolar Disorder	phv00035230	During this period, which one cigarette would you have hated most to give up? (Participants with European ancestry)
Whole Genome Association Study of Bipolar Disorder	phv00054538	During this period, which one cigarette would you have hated most to give up? (African American participants)

Mapping for PX031001_Former_Smoker_1stSmoke_Time

dbGAP Study	dbGAP Variable	dbGAP Variable Description
CARDIA Cohort	phv00115559	HOW SOON SMOKE AFTER WAKING. Q 2.09
Genetic Epidemiology of COPD (COPDGene)	phv00159636	How soon after waking do you smoke first cigarette
Genome-Wide Association Study of Schizophrenia	phv00020411	During this time when you smoked the most, how soon after waking did you smoke your first cigarette?
Genome-Wide Association Study of Schizophrenia	phv00034777	During this time when you smoked the most, how soon after waking did you smoke your first cigarette?
GWAS on Cataract and HDL in the PMRP	phv00181756	Former Smokers Question 17 - How soon after you wake up do/did you smoke your first cigarette?
Molecular Genetics of Schizophrenia - nonGAIN Sample (MGS_nonGAIN)	phv00071637	During this time when you smoked the most, how soon after waking did you smoke your first cigarette?
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00175431	TIME FROM WAKING UP TO SMOKING FIRST MORNING CIGARETTE
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00176865	TIME FROM WAKING UP TO SMOKING FIRST MORNING CIGARETTE
Study of Addiction: Genetics and Environment (SAGE)	phv00066369	Participant's lifetime score for Fagerstr??m Test for Nicotine Dependence (FTND) question 1: How soon after waking do you smoke your first cigarette?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162844	Participant's lifetime score for Fagerstr??m Test for Nicotine Dependence (FTND) question 1: How soon after waking do you smoke your first cigarette?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162924	Participant's lifetime score for Fagerstr??m Test for Nicotine Dependence (FTND) question 1: How soon after waking do you smoke your first cigarette?
Whole Genome Association Study of Bipolar Disorder	phv00015796	J4. Mins after Waking Smoke, (Participants with European ancestry). DIGS3
Whole Genome Association Study of Bipolar Disorder	phv00035228	During this time when you smoked the most, how soon after waking did you smoke your first cigarette? (Participants with European ancestry)
Whole Genome Association Study of Bipolar Disorder	phv00054536	During this time when you smoked the most, how soon after waking did you smoke your first cigarette? (African American participants)

Mapping for PX031001_Former_Smoker_More_1stHour

dbGAP Study	dbGAP Variable	dbGAP Variable Description
Genetic Epidemiology of COPD (COPDGene)	phv00159637	Smoke more during first 2 hours of day than rest of day
Genome-Wide Association Study of Schizophrenia	phv00020414	During this period, did you smoke more frequently during the first hours after waking than during the rest of the day?
Genome-Wide Association Study of Schizophrenia	phv00034780	During this period, did you smoke more frequently during the first hours after waking than during the rest of the day?
Jackson Heart Study (JHS) Cohort	phv00128502	6: Smoke more first few hrs after wake
Molecular Genetics of Schizophrenia - nonGAIN Sample (MGS_nonGAIN)	phv00071640	During this period, did you smoke more frequently during the first hours after waking than during the rest of the day?
Study of Addiction: Genetics and Environment (SAGE)	phv00066373	Participant's lifetime score for FTND question 5: Do you smoke more frequently during the first hours after waking than during the rest of the day?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162848	Participant's lifetime score for FTND question 5: Do you smoke more frequently during the first hours after waking than during the rest of the day?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162928	Participant's lifetime score for FTND question 5: Do you smoke more frequently during the first hours after waking than during the rest of the day?
Whole Genome Association Study of Bipolar Disorder	phv00015797	J5. Smoke More First Thing, (Participants with European ancestry). DIGS3
Whole Genome Association Study of Bipolar Disorder	phv00018288	J5. Smoke more after waking. (Participants with European ancestry). DIGS4
Whole Genome Association Study of Bipolar Disorder	phv00035231	During this period, did you smoke more frequently during the first hours after waking than during the rest of the day? (Participants with European ancestry)
Whole Genome Association Study of Bipolar Disorder	phv00054539	During this period, did you smoke more frequently during the first hours after waking than during the rest of the day? (African American participants)

Mapping for PX031001_Former_Smoker_Quantity_1Day

dbGAP Study	dbGAP Variable	dbGAP Variable Description
Atherosclerosis Risk in Communities (ARIC) Cohort	phv00207375	On the average of the entire time you smoked, how many cigarettes did you usually smoke per day? Q35 [Home Interview, exam 1]
Cardiovascular Health Study (CHS) Cohort	phv00197482	How many cigarettes per day did you average over all the time you smoked?
Cardiovascular Health Study (CHS) Cohort	phv00198830	24 average number of cigarettes/day
Framingham Cohort	phv00020929	IF EVER SMOKED CIGS REGULARLY: ON THE AVERAGE OF THE ENTIRE TIME YOU SMOKED, HOW MANY CIGARETTES DID YOU SMOKE PER DAY?
Framingham Cohort	phv00177305	Medical History-Smoking: Question refers to 'whole lifetime'. On the average of the entire time you smoked, how many cigarettes did you smoke per day?
Framingham Cohort	phv00072092	ON AVERAGE, SINCE YOUR LAST EXAM, HOW MANY CIGARETTES DID YOU SMOKE PER DAY?
Framingham Cohort	phv00056745	On average, during the entire time you smoked, how many cigarettes did you usually smoke per day?
Genetic Epidemiology of COPD (COPDGene)	phv00159762	On average ounces of tobacco smoked per week [oz per week]
Genetic Epidemiology of COPD (COPDGene)	phv00159752	Average for entire time how many cigarettes smoked per day [cigarettes/day]
GENEVA Genetics of Early Onset Stroke (GEOS) Study	phv00111939	For current smokers, the average number of packs smoked per day (1 pack=20 cigarettes)
GWAS on Cataract and HDL in the PMRP	phv00181744	Protocol C is used with adults who are Former Smokers. Question 7a - When you last smoked every day, on average how many cigarettes did you smoke each day? Go to question 8
GWAS on Cataract and HDL in the PMRP	phv00181759	Former Smokers Question 20 - How many cigarettes per day do/did you smoke?
GWAS on Cataract and HDL in the PMRP	phv00181745	Protocol C is used with adults who are Former Smokers. Question 7b - When you last smoked every day, on average how many cigarettes did you smoke each day? Go to question 8
HMP Core Microbiome Sampling Protocol A (HMP-A)	phv00158620	Frequency of cigarette
HMP Core Microbiome Sampling Protocol A (HMP-A)	phv00158621	Frequency of cigarette - coded fields
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00085574	CIGARETTES: AVERAGE
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00176867	AVERAGE CIGARETTES SMOKED PER DAY
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00175433	AVERAGE CIGARETTES SMOKED PER DAY
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00087256	AVERAGE NUMBER OF CIGARETTES SMOKED PER DAY
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00087014	AVERAGE CIGARETTES SMOKED PER DAY
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00086582	CIGARETTES: AVERAGE
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00086098	CIGARETTES: AVERAGE
Multi-Ethnic Study of Atherosclerosis (MESA) Cohort	phv00083247	CIGARETTES: AVERAGE
NEI Age-Related Eye Disease Study (AREDS)	phv00053863	AVERAGE PACKS PER DAY SMOKED (ALL PARTICIPANTS)
NEI Age-Related Eye Disease Study (AREDS)	phv00053990	AVERAGE PACKS PER DAY SMOKED (ALL PARTICIPANTS)
NHLBI Cleveland Family Study (CFS) Candidate Gene Association Resource (CARe)	phv00123027	Smoking: Average packs smoked/year
NHLBI Cleveland Family Study (CFS) Candidate Gene Association Resource (CARe)	phv00122546	Average number of cigarettes smoked/day (C)
NHLBI Cleveland Family Study (CFS) Candidate Gene Association Resource (CARe)	phv00122342	Average number of cigarettes smoke per day (A)
NIA Long Life Family Study (LLFS)	phv00163301	Average Number of Cigarettes Usually Smoke(d) Per Day
The Vaginal Microbiome: Disease, Genetics and the Environment	phv00090475	During the last 30 days, on average, how many cigarettes have you smoked per day?

Mapping for PX031001_Former_Smoker_Refraining_Difficulty

dbGAP Study	dbGAP Variable	dbGAP Variable Description
Genetic Epidemiology of COPD (COPDGene)	phv00159639	Do you find it hard to not smoke in forbidden places
Genome-Wide Association Study of Schizophrenia	phv00020412	Did you find it difficult to refrain from smoking in places where it is forbidden, e.g., in church, at the library, in the cinema, etc.?
Genome-Wide Association Study of Schizophrenia	phv00034778	Did you find it difficult to refrain from smoking in places where it is forbidden, e.g., in church, at the library, in the cinema, etc.?
Molecular Genetics of Schizophrenia - nonGAIN Sample (MGS_nonGAIN)	phv00071638	Did you find it difficult to refrain from smoking in places where it is forbidden, e.g., in church, at the library, in the cinema, etc.?
Study of Addiction: Genetics and Environment (SAGE)	phv00066370	Participant's lifetime score for FTND question 2: Do you find it difficult to refrain from smoking in places where it is forbidden?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162845	Participant's lifetime score for FTND question 2: Do you find it difficult to refrain from smoking in places where it is forbidden?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162925	Participant's lifetime score for FTND question 2: Do you find it difficult to refrain from smoking in places where it is forbidden?
Whole Genome Association Study of Bipolar Disorder	phv00018290	J6. Forbidden places. (Participants with European ancestry). DIGS4
Whole Genome Association Study of Bipolar Disorder	phv00035229	Did you find it difficult to refrain from smoking in places where it is forbidden, e.g., in church, at the library, in the cinema, etc.? (Participants with European ancestry)
Whole Genome Association Study of Bipolar Disorder	phv00052658	J6 Forbidden places, (African American participants). DIGS4
Whole Genome Association Study of Bipolar Disorder	phv00054537	Did you find it difficult to refrain from smoking in places where it is forbidden, e.g., in church, at the library, in the cinema, etc.? (African American participants)

Mapping for PX031001_Former_Smoker_Smoking_During_Illness

dbGAP Study	dbGAP Variable	dbGAP Variable Description
Genetic Epidemiology of COPD (COPDGene)	phv00159640	Smoke when so ill you are in bed most of day
Genome-Wide Association Study of Schizophrenia	phv00020415	During this period, did you smoke if you are so ill that you are in bed most of the day?
Genome-Wide Association Study of Schizophrenia	phv00034781	During this period, did you smoke if you are so ill that you are in bed most of the day?
GWAS on Cataract and HDL in the PMRP	phv00181761	Former Smokers Question 22 - Did you smoke if you are so ill that you are in bed most of the day?
Jackson Heart Study (JHS) Cohort	phv00128506	10: Smoke when ill?
Molecular Genetics of Schizophrenia - nonGAIN Sample (MGS_nonGAIN)	phv00071641	During this period, did you smoke if you are so ill that you are in bed most of the day?
Study of Addiction: Genetics and Environment (SAGE)	phv00066374	Participant's lifetime score for FTND question 6: Do you smoke when you are so ill that you are in bed most of the day?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162849	Participant's lifetime score for FTND question 6: Do you smoke when you are so ill that you are in bed most of the day?
The Genetic Architecture of Smoking and Smoking Cessation	phv00162929	Participant's lifetime score for FTND question 6: Do you smoke when you are so ill that you are in bed most of the day?
Whole Genome Association Study of Bipolar Disorder	phv00015800	J8. Smoked While Ill in Bed, (Participants with European ancestry). DIGS3
Whole Genome Association Study of Bipolar Disorder	phv00015858	J19. Smoke w Serious Ill Spec, (Participants with European ancestry). DIGS3
Whole Genome Association Study of Bipolar Disorder	phv00018294	J8. Smoked even when ill. (Participants with European ancestry). DIGS4
Whole Genome Association Study of Bipolar Disorder	phv00035232	During this period, did you smoke if you are so ill that you are in bed most of the day? (Participants with European ancestry)
Whole Genome Association Study of Bipolar Disorder	phv00052660	J8 Smoked even when ill, (African American participants). DIGS4
Whole Genome Association Study of Bipolar Disorder	phv00054540	During this period, did you smoke if you are so ill that you are in bed most of the day? (African American participants)

Protocol - Cigarette Nicotine Dependence

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