Protocol - Substances - Lifetime Use

Personnel and Training Required

The interviewer must be trained and found competent to conduct personal interviews with individuals from the general population. The interviewer should be trained to prompt respondents further if a "don’t know" response is provided. It is preferable either to read the questionnaire aloud to the respondent or administer it in an audio-assisted computer interview (ACASI) format. The questions are sensitive in nature, and the interviewer should be trained to react appropriately to emotional responses. If a distressed respondent protocol is adopted, the interviewer should be trained to administer those procedures.

Equipment Needs

While the Alcohol Use Disorder and Associated Disabilities Interview Schedule-5 (AUDADIS-5) instrument was developed for administration by computer, the PhenX WG acknowledges that these questions can be administered in a noncomputerized format. Hasin et al. (1997) and Grant et al. (1995) used the AUDADIS in paper-and-pencil format, while Grant et al. (2003) obtained data with the computerized format.

Requirements

Requirement Category	Required
Major equipment	No
Specialized training	No
Specialized requirements for biospecimen collection	No
Average time of greater than 15 minutes in an unaffected individual	No

Mode of Administration

Interviewer-administered questionnaire

Lifestage

Adult

Participants

Adults aged 18 years or older

Selection Rationale

The National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III) captures "diagnostic" information via the Alcohol Use Disorder and Associated Disabilities Interview Schedule (AUDADIS-5). Therefore, the user can link diagnostic data from the NESARC directly to treatment utilization also collected from the NESARC.

Language

English

Standards

Standard	Name	ID	Source
caDSR Form	PhenX PX031102 - Substances Lifetime Use	6872198	caDSR Form

Derived Variables

None

Process and Review

The Expert Review Panel 3 (ERP3) reviewed the measures in the Alcohol, Tobacco and Other Substances domain and in the Substance Abuse and Addiction Collection.

Guidance from the ERP includes:

• Updated protocol (same source)

Partially back-compatible (updated/similar protocol which would require some changes to the data dictionary), variable mapping between current and previous protocols can be found here (link).

Previous version in Toolkit archive.

Protocol Name from Source

National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III)

Source

National Institute on Alcohol Abuse and Alcoholism (NIAAA). (N.d.). National Epidemiologic Survey on Alcohol and Related Conditions-III (NESARC-III). Rockville, MD: National Institutes of Health. Alcohol Use Disorder and Associated Disabilities Interview Schedule (AUDADIS-5), Section 3B - Medicine Use (Question 1a).

General References

Grant, B. F., Dawson, D. A., Stinson, F. S., Chou, P. S., Kay, W., & Pickering, R. (2003). The Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV): Reliability of alcohol consumption, tobacco use, family history of depression and psychiatric diagnostic modules in a general population sample. Drug and Alcohol Dependence, 71(1), 7-16.

Grant, B. F., Goldstein, R. B., Saha, T. D., Chou, S. P., Jung, J., Zhang, H., Pickering, R. P., Ruan, W. J., Smith, S. M., Huang, B., Hasin, D. S. (2015). Epidemiology of DSM-5 Alcohol Use Disorder: Results from the National Epidemiologic Survey on Alcohol and Related Conditions III. JAMA Psychiatry, 72(8), 757-766.

Grant, B. F., Goldstein, R. B., Smith, S. M., Jung, J., Zhang, H., Chou, S. P., Pickering, R. P., Ruan, W. J., Huang, B., Saha, T. D., Aivadyan, C., Greenstein, E., & Hasin, D. S. (2015). The Alcohol Use Disorder and Associated Disabilities Interview Schedule-5 (AUDADIS-5): Reliability of substance use and psychiatric disorder modules in a general population sample. Drug and Alcohol Dependence, 148, 27-33.

Grant, B. F., Harford, T. C., Dawson, D. A., Chou, P. S., & Pickering, R. P. (1995). The Alcohol Use Disorder and Associated Disabilities Interview Schedule (AUDADIS): Reliability of alcohol and drug modules in a general population sample. Drug and Alcohol Dependence, 39(1), 37-44.

Hasin, D., Carpenter, K. M., McCloud, S., Smith, M., & Grant, B. F. (1997). The alcohol use disorder and associated disabilities interview schedule (AUDADIS): Reliability of alcohol and drug modules in a clinical sample. Drug and Alcohol Dependence, 44(2-3), 133-141.

Hasin, D. S., Greenstein, E., Aivadyan, C., Stohl, M., Aharonovich, E., Saha, T., Goldstein, R., Nunes, E. V., Jung, J., Zhang, H., & Grant, B. F. (2015). The Alcohol Use Disorder and Associated Disabilities Interview Schedule-5 (AUDADIS-5): Procedural validity of substance use disorders modules through clinical re-appraisal in a general population sample. Drug and Alcohol Dependence, 148, 40-46.

Hasin, D. S., O’Brien, C. P., Auriacombe, M., Borges, G., Bucholz, K., Budney, A., Compton, W. M., Crowley, T., Ling, W., Petry, N. M., Schuckit, M., & Grant, B. F. (2013). DSM-5 criteria for substance use disorders: Recommendations and rationale. American Journal of Psychiatry, 170(8), 834-851.

Protocol ID

31102

Variables

Export Variables

Variable Name	Variable ID	Variable Description	dbGaP Mapping
PX031102_Substances_Lifetime_Use_Classify_User
	PX031102020000	Is at least one category marked in 1a?	N/A
PX031102_Substances_Lifetime_Use_Club_Drugs
	PX031102010600	Have you EVER used any of these medicines or more drugs? Club drugs, for exampleÆ’MDMA, ecstasy, GHB, Ro-hip'-nol, kett'-amine, Special K, XTC, roofies. show less	N/A
PX031102_Substances_Lifetime_Use_Cocaine
	PX031102010400	Have you EVER used any of these medicines or more drugs? Cocaine or crack, for exampleÆ’blow, rock, snow. show less	N/A
PX031102_Substances_Lifetime_Use_Hallucinogens
	PX031102010700	Have you EVER used any of these medicines or more drugs? Hallucinogens, for exampleÆ’LSD, acid, PCP, mescaline, pay-o'-tee, sillosy'-bin, mushrooms, angel dust, cactus. show less	N/A
PX031102_Substances_Lifetime_Use_Heroin
	PX031102010900	Have you EVER used any of these medicines or more drugs? Heroin, for exampleÆ’smack, black tar, poppy. show less	N/A
PX031102_Substances_Lifetime_Use_Inhalants
	PX031102010800	Have you EVER used any of these medicines or more drugs? Inhalants or solvents, for exampleÆ’nitrous oxide, lighter fluid, gasoline, cleaning fluid, glue, poppers, whippets. show less	N/A
PX031102_Substances_Lifetime_Use_Marijuana
	PX031102010300	Have you EVER used any of these medicines or more drugs? Mariwa'-na, including THC, for exampleÆ’weed, pot, dope, hashish, Mary Jane, joint, blunt. show less	N/A
PX031102_Substances_Lifetime_Use_Other
	PX031102011000	Have you EVER used any of these medicines or more drugs? Any OTHER medicines or drugs, for exampleÆ’steroids, Elavil, Thoarazine, or Haldol. show less	N/A
PX031102_Substances_Lifetime_Use_Painkillers
	PX031102010200	Have you EVER used any of these medicines or more drugs? Painkillers, for exampleÆ’methadone, codeine, Demerol, Vy'-ko-din, Oxi-kon'-tin, opium, oxy, Per'-ko-set, Dill-odd'-id, Per'-ko-dan, morphine. show less	N/A
PX031102_Substances_Lifetime_Use_Sedatives
	PX031102010100	Have you EVER used any of these medicines or more drugs? Sedatives or tranquilizers, for exampleÆ’barbs, downers, Am'-bee-en, Lunesta, phenobarbital, pentobarbital, Hal'-see-on, Tuinal, Nembutal, Seconal, Librium, Valium, Xanax, benzodiayz'-a-peens, tr show less	N/A
PX031102_Substances_Lifetime_Use_Stimulants
	PX031102010500	Have you EVER used any of these medicines or more drugs? Stimulants, for exampleÆ’Add'-erall, Concerta, Sy'-lert, Pro-vig'-il, Ritalin or Dexedrine, speed, amphetamine, methamphetamine, uppers, bennies, pep pills, crystal, crank. show less	N/A

Alcohol, Tobacco and Other Substances

Measure Name

Substances - Lifetime Use

Release Date

November 28, 2017

Definition

Questions ask the respondent if he or she has ever used a drug during his or her entire life.

Purpose

This measure can be used to assess the participant’s lifetime use of any drug. The question is often used as a prelude to more detailed questions about substance use to screen out individuals who have ever used these substances.

Keywords

Drugs, substance use, illicit substances, Alcohol Use Disorder and Associated Disabilities Interview Schedule, AUDADIS, National Institute on Alcohol Abuse and Alcoholism, NIAAA, National Epidemiologic Survey on Alcohol and Related Conditions, NESARC, Diagnostic and Statistical Manual of Mental Disorders, DSM, alcohol, Tobacco and Other Substances, ATOS, gerontology, aging, geriatrics

Measure Protocols

Protocol ID	Protocol Name
31102	Substances - Lifetime Use

Publications

Garrison-Desany, H. M., et al. (2024) Post-traumatic stress and future substance use outcomes: leveraging antecedent factors to stratify risk Frontiers in Psychiatry. 2024 March; 15. doi: 10.3389/fpsyt.2024.1249382

Kim-Spoon, J., et al. (2019) Longitudinal pathways linking family risk, neural risk processing, delay discounting, and adolescent substance use. Journal of Child Psychology and Psychiatry. 2019 February; 60(6): 655-664. doi: 10.1111/jcpp.13015