Protocol - Exogenous Female Hormone Use
Description
Female respondents self-report the use of estrogen and progesterone, including the duration and dose.
Specific Instructions
None
Availability
Protocol
1. Have you ever taken estrogen ("female hormones") for symptoms of menopause (the change of life) or for other reasons?
[ ] No (go to question 11)
[ ] Yes, and I am currently taking estrogens
[ ] Yes, but I am no longer taking estrogens
2. The most frequently used estrogen is oral Premarin®. Have you ever taken Premarin® by mouth (as pills)?
[ ] No (go to question 7)
[ ] Yes
3. At what age did you first take Premarin®?
[ ] Before age 45
[ ] 45-49
[ ] 50-54
[ ] 55-59
[ ] 60-64
[ ] 65-69
[ ] 70 or older
4. At what age did you last take Premarin®?
[ ] Currently taking
[ ] Before age 45
[ ] 45-49
[ ] 50-54
[ ] 55-59
[ ] 60-64
[ ] 65-69
[ ] 70 or older
5. How many years in total did you take Premarin® (exclude those periods when you temporarily stopped)?
YEARS __ (If less than 1 year, mark as 1)
| 6. Five commonly used doses of Premarin® can be distinguished by the color of the pill. Please indicate any you have ever used and the one you used for the longest period. | |||
| Ever Used | Longest Used | ||
| (Answer for each) | (Mark one) | ||
| No | Yes | [_] | |
| Green (0.3 mg) | [_] | [_] | [_] |
| Brown/Red (0.625 mg) | [_] | [_] | [_] |
| White (0.9 mg) | [_] | [_] | [_] |
| Yellow/Orange (1.25 mg) | [_] | [_] | [_] |
| Purple (2.5 mg) | [_] | [_] | [_] |
7. Have you ever used estrogen other than Premarin® pills? (Answer for each)
Estrogen by mouth
[ ] No
[ ] Yes
Estrogen by injection
[ ] No
[ ] Yes
Estrogen by patch or implant
[ ] No
[ ] Yes
Estrogen vaginal cream or suppository
[ ] No
[ ] Yes
If you answered no to all parts of question 7, go to question 11.
8. At what age did you first use estrogens other than Premarin® pills?
[ ] Before age 45
[ ] 45-49
[ ] 50-54
[ ] 55-59
[ ] 60-64
[ ] 65-69
[ ] 70 or older
9. At what age did you last use estrogens other than Premarin® pills?
[ ] Currently taking
[ ] Before age 45
[ ] 45-49
[ ] 50-54
[ ] 55-59
[ ] 60-64
[ ] 65-69
[ ] 70 or older
10. How many years in total did you take estrogens other than Premarin® pills (exclude any time when you temporarily stopped)?
[ ] Less than 1 year
[ ] 1-2
[ ] 3-5
[ ] 6-9
[ ] 10-14
[ ] 15-19
20[ ]years or more
11. Sometimes another type of female hormone, progesterone (or "progestin"), is given for symptoms of menopause, either alone or in combination with estrogen. The most frequently used progestin is Provera® (medroxyprogesterone acetate). Have you ever used progesterone or a progestin?
[ ] No (End Survey)
[ ] Provera® only
[ ] Another type only
[ ] Provera® and another type of progestin
[ ] Yes, but dont know type
12. At what age did you first take progesterone or a progestin?
[ ] Before age 40
[ ] 40-44
[ ] 45-49
[ ] 50-54
[ ] 55-59
[ ] 60-64
[ ] 65-69
70[ ]years or older
13. At what age did you last take progesterone or a progestin?
[ ] Currently taking
[ ] Before 45
[ ] 45-49
[ ] 50-54
[ ] 55-59
[ ] 60-64
[ ] 65-69
70[ ]years or older
14. How many years in total did you take progesterone or a progestin (excluding any time when you temporarily stopped)?
[ ] Less than 1 year
[ ] 1-2
[ ] 3-5
[ ] 6-9
[ ] 10-14
[ ] 15-19
20[ ]years or more
15. If you used Provera®, what was your usual dose?
[ ] Did not use Provera®
2.5[ ]mg per day
5.0[ ]mg per day
10[ ]mg per day
20[ ]mg per day
[ ] Another dose
[ ] Dont know
16. When using progestin or progesterone, for how many days each month would you usually take it?
__[ ]DAYS
Premarin® is a registered trademark, Wyeth Pharmaceuticals, Inc.; Provera® is a registered trademark, Pfizer, Inc.
Personnel and Training Required
None
Equipment Needs
None
Requirements
| Requirement Category | Required |
|---|---|
| Major equipment | No |
| Specialized training | No |
| Specialized requirements for biospecimen collection | No |
| Average time of greater than 15 minutes in an unaffected individual | No |
Mode of Administration
Self-administered questionnaire
Lifestage
Adult
Participants
Females aged 21 years and older, current and former public school teachers or administrators who participate in the California State Teachers Retirement System (STRS)*
*While this protocol was used in a study of California women, the Cancer Working Group deems it appropriate to use with women aged 18 years old and above.
Selection Rationale
This protocol was selected because it obtains detailed information of the most frequently used female hormones: estrogen (Premarin®) and progesterone (Provera®).
Language
Chinese, English
Standards
| Standard | Name | ID | Source |
|---|---|---|---|
| Logical Observation Identifiers Names and Codes (LOINC) | Exogenous female hormone proto | 62565-7 | LOINC |
| Human Phenotype Ontology | Abnormal circulating estrogen level | HP:0025132 | HPO |
| caDSR Form | PhenX PX070401 - Exogenous Female Hormone Use | 5872630 | caDSR Form |
Derived Variables
None
Process and Review
Not applicable.
Protocol Name from Source
The California Teachers Study, Baseline, Fall 1995
Source
State of California, The California Teachers Study, Baseline, Fall 1995, questions 41–56, pages 6 and 7 (source for questions 1–16).General References
Protocol ID
70401
Variables
Export Variables| Variable Name | Variable ID | Variable Description | dbGaP Mapping | |
|---|---|---|---|---|
| PX070401_Estrogen_Except_Premarin_Age_First | ||||
| PX070401080000 | At what age did you first use estrogens more | N/A | ||
| PX070401_Estrogen_Except_Premarin_Age_Last | ||||
| PX070401090000 | At what age did you last use estrogens other more | N/A | ||
| PX070401_Estrogen_Except_Premarin_Years | ||||
| PX070401100000 | How many years in total did you take more | N/A | ||
| PX070401_Ever_Estrogen_By_Cream_Suppository | ||||
| PX070401070400 | Have you ever used estrogen other than more | N/A | ||
| PX070401_Ever_Estrogen_By_Injection | ||||
| PX070401070200 | Have you ever used estrogen other than more | N/A | ||
| PX070401_Ever_Estrogen_By_Mouth | ||||
| PX070401070100 | Have you ever used estrogen other than more | N/A | ||
| PX070401_Ever_Estrogen_By_Patch_Implant | ||||
| PX070401070300 | Have you ever used estrogen other than more | N/A | ||
| PX070401_Ever_Premarin | ||||
| PX070401020000 | The most frequently used estrogen is oral more | N/A | ||
| PX070401_Ever_Progesterone_Progestin | ||||
| PX070401110000 | Sometimes another type of female hormone, more | N/A | ||
| PX070401_Ever_Taken_Estrogen | ||||
| PX070401010000 | Have you ever taken estrogen (female more | Variable Mapping | ||
| PX070401_Premarin_Age_First | ||||
| PX070401030000 | At what age did you first take Premarin? | N/A | ||
| PX070401_Premarin_Age_Last | ||||
| PX070401040000 | At what age did you last take Premarin? | N/A | ||
| PX070401_Premarin_Dose_Brown_Red | ||||
| PX070401060200 | Five commonly used doses of Premarin can be more | N/A | ||
| PX070401_Premarin_Dose_Green | ||||
| PX070401060100 | Five commonly used doses of Premarin can be more | N/A | ||
| PX070401_Premarin_Dose_Longest_Used | ||||
| PX070401060600 | Longest Used | N/A | ||
| PX070401_Premarin_Dose_Purple | ||||
| PX070401060500 | Five commonly used doses of Premarin can be more | N/A | ||
| PX070401_Premarin_Dose_White | ||||
| PX070401060300 | Five commonly used doses of Premarin can be more | N/A | ||
| PX070401_Premarin_Dose_Yellow_Orange | ||||
| PX070401060400 | Five commonly used doses of Premarin can be more | N/A | ||
| PX070401_Premarin_Years | ||||
| PX070401050000 | How many years in total did you take more | N/A | ||
| PX070401_Progesterone_Progestin_Age_First | ||||
| PX070401120000 | At what age did you first take progesterone more | N/A | ||
| PX070401_Progesterone_Progestin_Age_Last | ||||
| PX070401130000 | At what age did you last take progesterone more | Variable Mapping | ||
| PX070401_Progesterone_Progestin_Days | ||||
| PX070401160000 | When using progestin or progesterone, for more | Variable Mapping | ||
| PX070401_Progesterone_Progestin_Years | ||||
| PX070401140000 | How many years in total did you take more | Variable Mapping | ||
| PX070401_Provera_Dose | ||||
| PX070401150000 | If you used Provera, what was your usual dose? | N/A | ||
Measure Name
Exogenous Female Hormone Use
Release Date
December 30, 2009
Definition
Measure to assess use of the hormones estrogen and progesterone
Purpose
Estrogen and progesterone use has been linked to cancer risk. Assessing use of these hormones will help quantify their association with either increased or decreased risk of cancer.
Keywords
cancer, estrogen, progesterone, Premarin®, Provera®, hormones, risk, The California Teachers Study (CTS)
Measure Protocols
| Protocol ID | Protocol Name |
|---|---|
| 70401 | Exogenous Female Hormone Use |
Publications
There are no publications listed for this protocol.