Protocol - Parkinsons Disease Symptoms

Personnel and Training Required

The interviewer must be trained to and found competent to conduct motor examinations, as well as be competent to recognize the impact of comorbidities (such as stroke, arthritis, etc.) on motor movements. Additionally, the interviewer must be trained and found competent in the recognition of motor movements and ratings listed in this protocol, such as the signs and degree of tremor and rigidity and the presence of bradykinesia/hypokinesia.

Equipment Needs

None

Requirements

Requirement Category	Required
Major equipment	No
Specialized training	Yes
Specialized requirements for biospecimen collection	No
Average time of greater than 15 minutes in an unaffected individual	Yes

Mode of Administration

Physical Examination

Lifestage

Adult, Senior

Participants

Adult, aged 18 or older

Selection Rationale

The Movement Disorders Society United Parkinson’s Disease Rating Scale (MDS-UPDRS) was selected because it is the standard, validated protocol that is the most-widely used method to follow the progression of Parkinson’s disease over time.

Language

English

Standards

Standard	Name	ID	Source
Logical Observation Identifiers Names and Codes (LOINC)	Parkinsonian proto	62757-0	LOINC

Derived Variables

None

Process and Review

Expert Review Panel 4 (ERP 4) reviewed the measures in the Neurology, Psychiatric, and Psychosocial domains.

Guidance from ERP 4 included the following:

· Changed measure name

· Updated protocol

· Created new data dictionary

Previous version in Toolkit archive (link)

Protocol Name from Source

Movement Disorder Society United Parkinsons Disease Rating Scale (MDS-UPDRS)

Source

Goetz, C. G., Tilley, B .C., Shaftman, S. R., Stebbins, G. T., Fahn, S., Martinez-Martin, P., Poewe, W., Sampaio, C., Stern, M. B., Dodel, R., Dubois, B., Holloway, R., Jankovic, J., Kulisevsky, J., Lang, A. E., Lees, A., Leurgans, S., LeWitt, P. A., Nyenhuis, D., Olanow, C. W., Rascol, O., Schrag, A., Teresi, J. A., van Hilten, J. J., & LaPelle, N.; Movement Disorder Society UPDRS Revision Task Force. (2008). Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): Scale presentation and clinimetric testing results. Movement Disorders, 23(15), 2129-2170.

The Movement Disorder Society United Parkinson’s Disease Rating Scale (MDS-UPDRS) is a proprietary instrument and administration (with the exception of personal use) requires a license from the International Parkinson Movement Disorder Society.

General References

Aminoff, M. J., Greenberg, D. A., & Simon, R. P. (2005). Clinical neurology (6th ed.). New York: Lange/McGraw-Hill Medical.

Fahn, S., & Elton, R. L.; UPDRS Program Members. (1987). Unified Parkinson’s Disease Rating Scale. In S. Fahn, C. D. Marsden, M. Goldstein, D. B. Calne (Eds.). Recent developments in Parkinson’s disease, Vol 2. Florham Park; NJ: Macmillan Healthcare Information.

Goetz, C. G., Fahn, S., Martinez-Martin, P., Poewe, W., Sampaio, C., Stebbins, G. T., Stern, M. B., Tilley, B. C., Dodel, R., Dubois, B., Holloway, R., Jankovic, J., Kulisevsky, J., Lang, A. E., Lees, A., Leurgans, S., LeWitt, P. A., Nyenhuis, D., Olanow, C. W., Rascol, O., Schrag, A., Teresi, J. A., Van Hilten, J. J., & LaPelle, N. (2007). Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale (MDS-UPDRS): Process, format, and clinimetric testing plan. Movement Disorders, 22(1), 41-47.

Goetz, C. G., Stebbins, G. T., Chmura, T. A., Fahn, S., Poewe, W., & Tanner, C. M. (2010). Teaching program for the Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale: (MDS-UPDRS). Movement Disorders, 25(9), 1190-1194.

Hentz, J. G., Mehta, S. H., Shill, H. A., Driver-Dunckley, E., Beach, T. G., & Adler, C. H. (2015). Simplified conversion method for Unified Parkinson’s Disease Rating Scale motor examinations. Movement Disorders, 30(14), 1967-1970.

Jain, S., Himali, J., Beiser, A., Ton, T.G., Kelly-Hayes, M., Biggs, M. L., Delaney, J. A., Rosano, C., Seshadri, S., & Frank, S. A. (2015). Validation of secondary data sources to identify Parkinson disease against clinical diagnostic criteria. American Journal of Epidemiology 181(3), 185-190.

Protocol ID

130102

Variables

Export Variables

Variable Name	Variable ID	Variable Description	dbGaP Mapping
	PX130102000000	Protocol 130102 - proprietary. Check DCW for more contact. show less	N/A

Neurology

Measure Name

Parkinsons Disease Symptoms

Release Date

November 28, 2017

Definition

A physical examination to assess parkinsonism symptoms, including resting tremor, resistance to movement, slowed voluntary and automatic movement, and abnormal gait and posture.

Purpose

This measure is used to screen an individual for the symptoms of parkinsonism. Parkinsonism occurs in about 0.2% of the population and the risk increases with age. Parkinsonism can be caused by genetics, vascular disease, certain medications, and environmental contaminants such as manganese dust, carbon monoxide, or pesticides (Aminoff et al., 2005).

Keywords

Neurology, parkinsonism, Parkinson’s disease, movement disorders, ataxia, tremor, gait, posture, gerontology, aging, geriatrics

Measure Protocols

Protocol ID	Protocol Name
130102	Parkinsons Disease Symptoms

Publications

There are no publications listed for this protocol.