Protocol - Vitamin D
Description
Any methodology that uses the appropriate National Institute of Standards and Technology (NIST) standard reference material and whose use is monitored by participation in the Vitamin D External Quality Assessment Scheme (DEQAS), can be used to quantify vitamin D exposure.
Specific Instructions
None
Availability
Protocol
All bioassays that follow the guidelines present in the Description of Protocol are equally valid, and the data collected can be compared across studies.
Personnel and Training Required
Personnel and required training will depend on Vitamin D protocol selected.
Equipment Needs
Equipment needed will depend on Vitamin D protocol selected.
Requirements
| Requirement Category | Required |
|---|---|
| Major equipment | No |
| Specialized training | No |
| Specialized requirements for biospecimen collection | No |
| Average time of greater than 15 minutes in an unaffected individual | No |
Mode of Administration
Bioassay
Lifestage
Infant, Toddler, Child, Adolescent, Adult, Senior, Pregnancy
Participants
All ages, but most important for infants and the elderly
Selection Rationale
The PhenX Working Group selected this protocol because two recent systematic evidence-based reviews suggest that serum 25 hydroxy vitamin D is the best biomarker for vitamin D exposure and captures exposure levels from both diet and sunlight.
Language
Chinese, English
Standards
| Standard | Name | ID | Source |
|---|---|---|---|
| Logical Observation Identifiers Names and Codes (LOINC) | PhenX - vitamin D protocol | 62288-6 | LOINC |
| Human Phenotype Ontology | Vitamin D deficiency | HP:0100512 | HPO |
| Human Phenotype Ontology | Abnormality of viatmin D metabolism | HP:0100511 | HPO |
| caDSR Form | PhenX PX051101 - Vitamin D | 5850321 | caDSR Form |
Derived Variables
None
Process and Review
The Expert Review Panel #1 reviewed the measures in the Anthropometrics, Diabetes, Physical Activity and Physical Fitness, and Nutrition and Dietary Supplements domains.
Guidance from the ERP includes:
• No significant changes to measure
Back-compatible: no changes to Data Dictionary
Previous version in Toolkit archive (link)
Protocol Name from Source
Vitamin D External Quality Assessment Scheme (DEQAS)
Source
National Institute of Standards and Technology (NIST)
Vitamin D External Quality Assessment Scheme (DEQAS)
General References
None
Protocol ID
51101
Variables
Export Variables| Variable Name | Variable ID | Variable Description | dbGaP Mapping | |
|---|---|---|---|---|
| PX051101_VitaminD_Collection_NanogramsPerLiter | ||||
| PX051101010100 | Vitamin D Concentration in ng/L | Variable Mapping | ||
Measure Name
Vitamin D
Release Date
October 30, 2009
Definition
A measure to assess serum vitamin D.
Purpose
Vitamin D functions as a hormone and is one of the most important biological regulators of calcium metabolism, in conjunction with parathyroid hormone and calcitonin. The measurement of 25(OH)D (referred to as the vitamin D assay) is becoming increasingly important in managing patients with various disorders of calcium metabolism associated with rickets, neonatal hypocalcemia, pregnancy, nutritional and renal osteodystrophy, hypoparathyroidism, and postmenopausal osteoporosis.
Keywords
Nutrition and Dietary Supplements, calcitriol, calcium metabolism, Rickets, hypocalcemia, osteodystrophy, hypoparathyroidism, osteoporosis, DEQAS
Measure Protocols
| Protocol ID | Protocol Name |
|---|---|
| 51101 | Vitamin D |
Publications
Kwok, R. K., et al. (2017) The GuLF STUDY: A Prospective Study of Persons Involved in the Deepwater Horizon Oil Spill Response and Clean-Up. Environ Health Perspect. 2017 April; 125(4): 570-578. doi: 10.1289/EHP715