Protocol - Hormone Therapy
- Current Contraception Use - Female
- Current Contraception Use - Male
- Current Pregnancy Status - Self-Report
- Reproductive History - Female
- Reproductive History - Male
Description
This protocol includes 10 interviewer-administered questions from the Reproductive Health section of the National Health and Nutrition Examination Survey (NHANES) 2013-2014 that capture use of female hormones (including pills and patches) and duration of use.
Specific Instructions
The Sickle Cell Disease Genitourinary Working Group notes some questions in this assessment are sensitive. Investigators should provide a private space for completing assessments and to be prepared to offer appropriate support.
Availability
Protocol
Reproductive Health Questions from National Health and Nutrition Examination Survey (NHANES) 2013-2014
1. {Have you/Has SP} ever used female hormones such as estrogen and progesterone? Please include any forms of prescription female hormones, such as pills, creams, patches, and injectables, but do not include birth control methods or use for infertility.
[ ] 1 Yes
[ ] 2 No
[ ] 7 Refused
[ ] 9 Don’t Know
2. Which forms of female hormones {have you/has SP} used? (Code all that apply)
[ ] 10 Pills (go to question 3)
[ ] 11 Patches (go to question 7)
[ ] 12 Cream/Suppository/Injection
[ ] 77 Refused
[ ] 99 Don’t Know
3. {Have you/Has SP} ever taken female hormone pills containing estrogen only (like Premarin)? (Do not include birth control pills.)
[ ] 1 Yes
[ ] 2 No
[ ] 7 Refused
[ ] 9 Don’t Know
4. Not counting any time when {you/SP} stopped taking them, for how long altogether {did you take/did she take} pills containing estrogen only? (Code “1” for less than a month.)
|__|__| Enter Number
[ ] 77 Refused
[ ] 99 Don’t Know
Enter Unit
[ ] 1 Months
[ ] 2 Years
[ ] 7 Refused
[ ] 9 Don’t Know
5. {Have you/Has SP} taken female hormone pills containing both estrogen and progestin (like Prempro, Premphase)? (Do not include birth control pills.)
[ ] 1 Yes
[ ] 2 No (go to question 7)
[ ] 7 Refused (go to question 7)
[ ] 9 Don’t Know (go to question 7)
6. Not counting any time when {you/SP} stopped taking them, for how long altogether {did you take/did she take} pills containing both estrogen and progestin? (Code “1” for less than a month.)
|__|__| Enter Number
[ ] 77 Refused
[ ] 99 Don’t Know
Enter Unit
[ ] 1 Months
[ ] 2 Years
[ ] 7 Refused
[ ] 9 Don’t Know
7. {Have you/Has SP} ever used female hormone patches containing estrogen only?
[ ] 1 Yes
[ ] 2 No (go to question 9)
[ ] 7 Refused (go to question 9)
[ ] 9 Don’t Know (go to question 9)
8. Not counting any time when {you/SP} stopped using them, for how long altogether {did you use/did she use} patches containing estrogen only? (Code “1” for less than a month.)
|__|__| Enter Number
[ ] 77 Refused
[ ] 99 Don’t Know
Enter Unit
[ ] 1 Months
[ ] 2 Years
[ ] 7 Refused
[ ] 9 Don’t Know
9. {Have you/Has SP} used female hormone patches containing both estrogen and progestin?
[ ] 1 Yes
[ ] 2 No (go to end)
[ ] 7 Refused (go to end)
[ ] 9 Don’t Know (go to end)
10. Not counting any time when {you/SP} stopped using them, for how long altogether {did you use/did she use} patches containing both estrogen and progestin? (Code “1” for less than a month.)
|__|__| Enter Number
[ ] 77 Refused
[ ] 99 Don’t Know
Enter Unit
[ ] 1 Months
[ ] 2 Years
[ ] 7 Refused
[ ] 9 Don’t Know
Personnel and Training Required
No specific training is needed if data are collected through a self-administered questionnaire. If interviewers administer the questionnaire, the interviewer must be trained to conduct personal interviews with individuals from the general population and found competent to administer these particular questions (i.e., tested by an expert) at the completion of this training. The interviewer should be trained to prompt respondents further if a “don’t know” response is provided.
Equipment Needs
The PhenX Sickle Cell Disease Genitourinary Working Group acknowledges these questions can be administered in a computerized or noncomputerized format (i.e., paper-and-pencil instrument). Computer software is necessary to develop computer-assisted instruments. The interviewer will require a laptop computer/handheld computer to administer a computer-assisted questionnaire.
Requirements
| Requirement Category | Required |
|---|---|
| Major equipment | No |
| Specialized training | No |
| Specialized requirements for biospecimen collection | No |
| Average time of greater than 15 minutes in an unaffected individual | No |
Mode of Administration
Self-administered questionnaire
Lifestage
Adult
Participants
Adolescent and adult females
Selection Rationale
Compared to infertility questions found in other instruments, the National Health and Nutrition Examination Survey (NHANES) questions were selected because they excluded questions about contraception and collects detailed information about the type(s) of estrogen used.
Language
English
Standards
| Standard | Name | ID | Source |
|---|
Derived Variables
None
Process and Review
Not applicable
Protocol Name from Source
National Health and Nutrition Examination Survey (NHANES)
Source
National Health and Nutrition Examination Survey (NHANES) 2013-2014 Questionnaire, Reproductive Health section. Questions RHQ540 down to RHQ602U.
General References
North American Menopause Society (2010). Estrogen and progestogen use in postmenopausal women: 2010 position statement of The North American Menopause Society. Menopause, 17(2), 242–255.
Protocol ID
880901
Variables
Export Variables| Variable Name | Variable ID | Variable Description | dbGaP Mapping | |
|---|---|---|---|---|
| PX880901_Hormone_Therapy_Ever_Used_Estrogen_Progesterone | ||||
| PX880901010000 | {Have you/Has SP} ever used female hormones more | N/A | ||
| PX880901_Hormone_Therapy_Ever_Used_Estrogen_Progesterone_Which | ||||
| PX880901010100 | Which forms of female hormones {have you/has more | N/A | ||
| PX880901_Hormone_Therapy_Ever_Used_Patch_Estrogen_Only | ||||
| PX880901040000 | {Have you/Has SP} ever used female hormone more | N/A | ||
| PX880901_Hormone_Therapy_Ever_Used_Patch_Estrogen_Only_Number | ||||
| PX880901040200 | Not counting any time when {you/SP} stopped more | N/A | ||
| PX880901_Hormone_Therapy_Ever_Used_Patch_Estrogen_Only_Refuse | ||||
| PX880901040100 | Not counting any time when {you/SP} stopped more | N/A | ||
| PX880901_Hormone_Therapy_Ever_Used_Patch_Estrogen_Only_Unit | ||||
| PX880901040300 | Not counting any time when {you/SP} stopped more | N/A | ||
| PX880901_Hormone_Therapy_Ever_Used_Patch_Estrogen_Progesterone_Both | ||||
| PX880901050000 | {Have you/Has SP} used female hormone more | N/A | ||
| PX880901_Hormone_Therapy_Ever_Used_Patch_Estrogen_Progesterone_Both_Number | ||||
| PX880901050200 | Not counting any time when {you/SP} stopped more | N/A | ||
| PX880901_Hormone_Therapy_Ever_Used_Patch_Estrogen_Progesterone_Both_Refuse | ||||
| PX880901050100 | Not counting any time when {you/SP} stopped more | N/A | ||
| PX880901_Hormone_Therapy_Ever_Used_Patch_Estrogen_Progesterone_Both_Unit | ||||
| PX880901050300 | Not counting any time when {you/SP} stopped more | N/A | ||
| PX880901_Hormone_Therapy_Ever_Used_Pill_Estrogen_Only | ||||
| PX880901020000 | {Have you/Has SP} ever taken female hormone more | N/A | ||
| PX880901_Hormone_Therapy_Ever_Used_Pill_Estrogen_Only_Number | ||||
| PX880901020200 | Not counting any time when {you/SP} stopped more | N/A | ||
| PX880901_Hormone_Therapy_Ever_Used_Pill_Estrogen_Only_Refuse | ||||
| PX880901020100 | Not counting any time when {you/SP} stopped more | N/A | ||
| PX880901_Hormone_Therapy_Ever_Used_Pill_Estrogen_Only_Unit | ||||
| PX880901020300 | Not counting any time when {you/SP} stopped more | N/A | ||
| PX880901_Hormone_Therapy_Ever_Used_Pill_Estrogen_Progesterone_Both | ||||
| PX880901030000 | {Have you/Has SP} taken female hormone pills more | N/A | ||
| PX880901_Hormone_Therapy_Ever_Used_Pill_Estrogen_Progesterone_Both_Number | ||||
| PX880901030200 | Not counting any time when {you/SP} stopped more | N/A | ||
| PX880901_Hormone_Therapy_Ever_Used_Pill_Estrogen_Progesterone_Both_Refuse | ||||
| PX880901030100 | Not counting any time when {you/SP} stopped more | N/A | ||
| PX880901_Hormone_Therapy_Ever_Used_Pill_Estrogen_Progesterone_Both_Unit | ||||
| PX880901030300 | Not counting any time when {you/SP} stopped more | N/A | ||
Measure Name
Hormone Therapy
Release Date
August 15, 2023
Definition
Hormone therapy refers to the use of medications and patches that contain female hormones.
Purpose
Estrogen and progesterone use (used independently or in combination) has been linked to cancer risk. Assessing use of these hormones will help quantify their association with either increased or decreased risk for cancer. Additionally, in female patients with sickle cell disease, the hormone(s) used alter the individual’s risk for blood clots and stroke, and so understanding which medication(s) have been used throughout the lifetime is important to understanding that individual’s risk for certain complications.
Keywords
fertility, offspring, pregnancy, infertility, SCD, chronic disease, NHANES
Measure Protocols
| Protocol ID | Protocol Name |
|---|---|
| 880901 | Hormone Therapy |
Publications
There are no publications listed for this protocol.