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Protocol - Hormone Therapy

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Description

This protocol includes 10 interviewer-administered questions from the Reproductive Health section of the National Health and Nutrition Examination Survey (NHANES) 2013-2014 that capture use of female hormones (including pills and patches) and duration of use.

Specific Instructions

The Sickle Cell Disease Genitourinary Working Group notes some questions in this assessment are sensitive. Investigators should provide a private space for completing assessments and to be prepared to offer appropriate support.

Availability

Available

Protocol

Reproductive Health Questions from National Health and Nutrition Examination Survey (NHANES) 2013-2014

1. {Have you/Has SP} ever used female hormones such as estrogen and progesterone? Please include any forms of prescription female hormones, such as pills, creams, patches, and injectables, but do not include birth control methods or use for infertility.
 [ ] 1 Yes
 [ ] 2 No
 [ ] 7 Refused
 [ ] 9 Don’t Know

2. Which forms of female hormones {have you/has SP} used? (Code all that apply)
 [ ] 10 Pills (go to question 3)
 [ ] 11 Patches (go to question 7)
 [ ] 12 Cream/Suppository/Injection
 [ ] 77 Refused
 [ ] 99 Don’t Know

3. {Have you/Has SP} ever taken female hormone pills containing estrogen only (like Premarin)? (Do not include birth control pills.)
 [ ] 1 Yes
 [ ] 2 No
 [ ] 7 Refused
 [ ] 9 Don’t Know

4. Not counting any time when {you/SP} stopped taking them, for how long altogether {did you take/did she take} pills containing estrogen only? (Code “1” for less than a month.)
 |__|__| Enter Number
 [ ] 77 Refused
 [ ] 99 Don’t Know

 Enter Unit
 [ ] 1 Months
 [ ] 2 Years
 [ ] 7 Refused
 [ ] 9 Don’t Know

5. {Have you/Has SP} taken female hormone pills containing both estrogen and progestin (like Prempro, Premphase)? (Do not include birth control pills.)
 [ ] 1 Yes
 [ ] 2 No (go to question 7)
 [ ] 7 Refused (go to question 7)
 [ ] 9 Don’t Know (go to question 7)

6. Not counting any time when {you/SP} stopped taking them, for how long altogether {did you take/did she take} pills containing both estrogen and progestin? (Code “1” for less than a month.)
 |__|__| Enter Number
 [ ] 77 Refused
 [ ] 99 Don’t Know

 Enter Unit
 [ ] 1 Months
 [ ] 2 Years
 [ ] 7 Refused
 [ ] 9 Don’t Know

7. {Have you/Has SP} ever used female hormone patches containing estrogen only?
 [ ] 1 Yes
 [ ] 2 No (go to question 9)
 [ ] 7 Refused (go to question 9)
 [ ] 9 Don’t Know (go to question 9)

8. Not counting any time when {you/SP} stopped using them, for how long altogether {did you use/did she use} patches containing estrogen only? (Code “1” for less than a month.)
 |__|__| Enter Number
 [ ] 77 Refused
 [ ] 99 Don’t Know

 Enter Unit
 [ ] 1 Months
 [ ] 2 Years
 [ ] 7 Refused
 [ ] 9 Don’t Know

9. {Have you/Has SP} used female hormone patches containing both estrogen and progestin?
 [ ] 1 Yes
 [ ] 2 No (go to end)
 [ ] 7 Refused (go to end)
 [ ] 9 Don’t Know (go to end)

10. Not counting any time when {you/SP} stopped using them, for how long altogether {did you use/did she use} patches containing both estrogen and progestin? (Code “1” for less than a month.)
 |__|__| Enter Number
 [ ] 77 Refused
 [ ] 99 Don’t Know

 Enter Unit
 [ ] 1 Months
 [ ] 2 Years
 [ ] 7 Refused
 [ ] 9 Don’t Know

Personnel and Training Required

No specific training is needed if data are collected through a self-administered questionnaire. If interviewers administer the questionnaire, the interviewer must be trained to conduct personal interviews with individuals from the general population and found competent to administer these particular questions (i.e., tested by an expert) at the completion of this training. The interviewer should be trained to prompt respondents further if a “don’t know” response is provided.

Equipment Needs

The PhenX Sickle Cell Disease Genitourinary Working Group acknowledges these questions can be administered in a computerized or noncomputerized format (i.e., paper-and-pencil instrument). Computer software is necessary to develop computer-assisted instruments. The interviewer will require a laptop computer/handheld computer to administer a computer-assisted questionnaire.

Requirements
Requirement CategoryRequired
Major equipment No
Specialized training No
Specialized requirements for biospecimen collection No
Average time of greater than 15 minutes in an unaffected individual No
Mode of Administration

Self-administered questionnaire

Lifestage

Adult

Participants

Adolescent and adult females

Selection Rationale

Compared to infertility questions found in other instruments, the National Health and Nutrition Examination Survey (NHANES) questions were selected because they excluded questions about contraception and collects detailed information about the type(s) of estrogen used.

Language

English

Standards
StandardNameIDSource
Derived Variables

None

Process and Review

Not applicable

Protocol Name from Source

National Health and Nutrition Examination Survey (NHANES)

Source

National Health and Nutrition Examination Survey (NHANES) 2013-2014 Questionnaire, Reproductive Health section. Questions RHQ540 down to RHQ602U.

General References

North American Menopause Society (2010). Estrogen and progestogen use in postmenopausal women: 2010 position statement of The North American Menopause Society. Menopause, 17(2), 242–255.

Protocol ID

880901

Variables
Export Variables
Variable Name Variable IDVariable DescriptiondbGaP Mapping
PX880901_Hormone_Therapy_Ever_Used_Estrogen_Progesterone
PX880901010000 {Have you/Has SP} ever used female hormones more
such as estrogen and progesterone? Please include any forms of prescription female hormones, such as pills, creams, patches, and injectables, but do not include birth control methods or use for infertility. show less
N/A
PX880901_Hormone_Therapy_Ever_Used_Estrogen_Progesterone_Which
PX880901010100 Which forms of female hormones {have you/has more
SP} used? (Code all that apply) show less
N/A
PX880901_Hormone_Therapy_Ever_Used_Patch_Estrogen_Only
PX880901040000 {Have you/Has SP} ever used female hormone more
patches containing estrogen only? show less
N/A
PX880901_Hormone_Therapy_Ever_Used_Patch_Estrogen_Only_Number
PX880901040200 Not counting any time when {you/SP} stopped more
using them, for how long altogether {did you use/did she use} patches containing estrogen only? (Code "1" for less than a month.) Enter Number show less
N/A
PX880901_Hormone_Therapy_Ever_Used_Patch_Estrogen_Only_Refuse
PX880901040100 Not counting any time when {you/SP} stopped more
using them, for how long altogether {did you use/did she use} patches containing estrogen only? (Code "1" for less than a month.) show less
N/A
PX880901_Hormone_Therapy_Ever_Used_Patch_Estrogen_Only_Unit
PX880901040300 Not counting any time when {you/SP} stopped more
using them, for how long altogether {did you use/did she use} patches containing estrogen only? (Code "1" for less than a month.) Enter Unit show less
N/A
PX880901_Hormone_Therapy_Ever_Used_Patch_Estrogen_Progesterone_Both
PX880901050000 {Have you/Has SP} used female hormone more
patches containing both estrogen and progestin? show less
N/A
PX880901_Hormone_Therapy_Ever_Used_Patch_Estrogen_Progesterone_Both_Number
PX880901050200 Not counting any time when {you/SP} stopped more
using them, for how long altogether {did you use/did she use} patches containing both estrogen and progestin? (Code "1" for less than a month.) Enter Number show less
N/A
PX880901_Hormone_Therapy_Ever_Used_Patch_Estrogen_Progesterone_Both_Refuse
PX880901050100 Not counting any time when {you/SP} stopped more
using them, for how long altogether {did you use/did she use} patches containing both estrogen and progestin? (Code "1" for less than a month.) show less
N/A
PX880901_Hormone_Therapy_Ever_Used_Patch_Estrogen_Progesterone_Both_Unit
PX880901050300 Not counting any time when {you/SP} stopped more
using them, for how long altogether {did you use/did she use} patches containing both estrogen and progestin? (Code "1" for less than a month.) Enter Unit show less
N/A
PX880901_Hormone_Therapy_Ever_Used_Pill_Estrogen_Only
PX880901020000 {Have you/Has SP} ever taken female hormone more
pills containing estrogen only (like Premarin)? (Do not include birth control pills.) show less
N/A
PX880901_Hormone_Therapy_Ever_Used_Pill_Estrogen_Only_Number
PX880901020200 Not counting any time when {you/SP} stopped more
taking them, for how long altogether {did you take/did she take} pills containing estrogen only? (Code "1" for less than a month.) Enter number show less
N/A
PX880901_Hormone_Therapy_Ever_Used_Pill_Estrogen_Only_Refuse
PX880901020100 Not counting any time when {you/SP} stopped more
taking them, for how long altogether {did you take/did she take} pills containing estrogen only? (Code "1" for less than a month.) show less
N/A
PX880901_Hormone_Therapy_Ever_Used_Pill_Estrogen_Only_Unit
PX880901020300 Not counting any time when {you/SP} stopped more
taking them, for how long altogether {did you take/did she take} pills containing estrogen only? (Code "1" for less than a month.) Enter Unit show less
N/A
PX880901_Hormone_Therapy_Ever_Used_Pill_Estrogen_Progesterone_Both
PX880901030000 {Have you/Has SP} taken female hormone pills more
containing both estrogen and progestin (like Prempro, Premphase)? (Do not include birth control pills.) show less
N/A
PX880901_Hormone_Therapy_Ever_Used_Pill_Estrogen_Progesterone_Both_Number
PX880901030200 Not counting any time when {you/SP} stopped more
taking them, for how long altogether {did you take/did she take} pills containing both estrogen and progestin? (Code "1" for less than a month.) Enter Number show less
N/A
PX880901_Hormone_Therapy_Ever_Used_Pill_Estrogen_Progesterone_Both_Refuse
PX880901030100 Not counting any time when {you/SP} stopped more
taking them, for how long altogether {did you take/did she take} pills containing both estrogen and progestin? (Code "1" for less than a month.) show less
N/A
PX880901_Hormone_Therapy_Ever_Used_Pill_Estrogen_Progesterone_Both_Unit
PX880901030300 Not counting any time when {you/SP} stopped more
taking them, for how long altogether {did you take/did she take} pills containing both estrogen and progestin? (Code "1" for less than a month.) Enter Unit show less
N/A
SCD Genitourinary
Measure Name

Hormone Therapy

Release Date

August 15, 2023

Definition

Hormone therapy refers to the use of medications and patches that contain female hormones.

Purpose

Estrogen and progesterone use (used independently or in combination) has been linked to cancer risk. Assessing use of these hormones will help quantify their association with either increased or decreased risk for cancer. Additionally, in female patients with sickle cell disease, the hormone(s) used alter the individual’s risk for blood clots and stroke, and so understanding which medication(s) have been used throughout the lifetime is important to understanding that individual’s risk for certain complications.

Keywords

fertility, offspring, pregnancy, infertility, SCD, chronic disease, NHANES

Measure Protocols
Protocol ID Protocol Name
880901 Hormone Therapy
Publications

There are no publications listed for this protocol.