Loading…

Protocol - Thromboprophylaxis

Add to My Toolkit
Description

This protocol from the Prophylactic Anticoagulation and central Venous access device-related thromboembolism In adult Sickle cell patients (PAVIS) clinical trial captures whether a participant has had thromboprophylaxis along with the type, dose, and any additional information describing it.

Specific Instructions

The Sickle Cell Disease Working Group recommends that investigators also consider these related protocols: Thrombosis - Catheter-related and Thrombosis - Venous, non-catheter-related. They also suggest that investigators capture the start and stop dates of prophylaxis as well as the trimester.

Availability

Available

Protocol

Thrombophrophylaxis

[ ] Thromboprophylaxis (Prophylactic Anticoagulation)

                    Type: ________________________________

                    Dose: ________________________________

Description:
____________________________________________________

Personnel and Training Required

Personnel should be trained in medical record abstraction.

Equipment Needs

None

Requirements
Requirement CategoryRequired
Major equipment No
Specialized training No
Specialized requirements for biospecimen collection No
Average time of greater than 15 minutes in an unaffected individual No
Mode of Administration

Medical record abstraction

Lifestage

Child, Adolescent, Adult, Pregnancy

Participants

Children and adults with sickle cell disease

Selection Rationale

These questions from the Prophylactic Anticoagulation and central Venous access device-related thromboembolism In adult Sickle cell patients (PAVIS) clinical trial have been used in participants with sickle cell disease and are straightforward to either collect from the participant or abstract from the medical record.

Language

English

Standards
StandardNameIDSource
Derived Variables

None

Process and Review

Not Applicable

Protocol Name from Source

Prophylactic Anticoagulation and central Venous access device-related thromboembolism In adult Sickle cell patients (PAVIS)

Source

Forté, S., De Luna, G., Abdulrehman, J., Fadiga, N., Pestrin, O., Pham Hung dAlexandry dOrengiani, A. L., Aneke, J. C., Guillet, H., Budhram, D., Habibi, A., Ward, R., Bartolucci, P., & Kuo, K. H. M. (2022). Thromboprophylaxis Reduced Venous Thromboembolism in Sickle Cell Patients with Central Venous Access Devices: A Retrospective Cohort Study. Journal of clinical medicine, 11(5), 1193. https://doi.org/10.3390/jcm11051193

General References

Seaman, C. D., Yabes, J., Li, J., Moore, C. G., & Ragni, M. V. (2014). Venous thromboembolism in pregnant women with sickle cell disease: a retrospective database analysis. Thrombosis research, 134(6), 1249?1252. https://doi.org/10.1016/j.thromres.2014.09.037

Protocol ID

890101

Variables
Export Variables
Variable Name Variable IDVariable DescriptiondbGaP Mapping
PX890101_Thromboprophylaxis
PX890101010000 Thromboprophylaxis (Prophylactic Anticoagulation) N/A
PX890101_Thromboprophylaxis_Description
PX890101020000 more
escription: ____________________________________________________ show less
N/A
PX890101_Thromboprophylaxis_Dose
PX890101010200 Dose: ________________________________ N/A
PX890101_Thromboprophylaxis_Type
PX890101010100 Type: ________________________________ N/A
SCD Pregnancy
Measure Name

Thromboprophylaxis

Release Date

August 5, 2024

Definition

Thromboprophylaxis is an intervention to prevent the formation of a blood clot and can be pharmacologic (medication-based) or non-pharmacologic (such as compression stockings or ambulation).

Purpose

This measure is useful for assessing an individual’s history of thromboprophylaxis use.  Thromboprophylaxis has been shown to reduce venous thromboembolism (VTE) development. Both pregnancy and sickle cell disease are strong risk factors for VTE, and the combined risk is reported to be 1.5–5.0 times greater than pregnancy-related VTE in the general population (Seaman et al. 2014).

Keywords

Thromboprophylaxis, blood clot prevention, deep vein thrombosis, DVT, pulmonary embolism, venous thromboembolism, VTE

Measure Protocols
Protocol ID Protocol Name
890101 Thromboprophylaxis
Publications

There are no publications listed for this protocol.