Protocol - Thromboprophylaxis

Personnel and Training Required

Personnel should be trained in medical record abstraction.

Equipment Needs

None

Requirements

Requirement Category	Required
Major equipment	No
Specialized training	No
Specialized requirements for biospecimen collection	No
Average time of greater than 15 minutes in an unaffected individual	No

Mode of Administration

Medical record abstraction

Lifestage

Child, Adolescent, Adult, Pregnancy

Participants

Children and adults with sickle cell disease

Selection Rationale

These questions from the Prophylactic Anticoagulation and central Venous access device-related thromboembolism In adult Sickle cell patients (PAVIS) clinical trial have been used in participants with sickle cell disease and are straightforward to either collect from the participant or abstract from the medical record.

Language

English

Standards

Standard	Name	ID	Source

Derived Variables

None

Process and Review

Not Applicable

Protocol Name from Source

Prophylactic Anticoagulation and central Venous access device-related thromboembolism In adult Sickle cell patients (PAVIS)

Source

Forté, S., De Luna, G., Abdulrehman, J., Fadiga, N., Pestrin, O., Pham Hung D'Alexandry d'Orengiani, A. L., Aneke, J. C., Guillet, H., Budhram, D., Habibi, A., Ward, R., Bartolucci, P., & Kuo, K. H. M. (2022). Thromboprophylaxis Reduced Venous Thromboembolism in Sickle Cell Patients with Central Venous Access Devices: A Retrospective Cohort Study. Journal of clinical medicine, 11(5), 1193. https://doi.org/10.3390/jcm11051193

General References

Seaman, C. D., Yabes, J., Li, J., Moore, C. G., & Ragni, M. V. (2014). Venous thromboembolism in pregnant women with sickle cell disease: a retrospective database analysis. Thrombosis research, 134(6), 1249-1252. https://doi.org/10.1016/j.thromres.2014.09.037

Protocol ID

890101

Variables

Export Variables

Variable Name	Variable ID	Variable Description	dbGaP Mapping
PX890101_Thromboprophylaxis
	PX890101010000	Thromboprophylaxis (Prophylactic Anticoagulation)	N/A
PX890101_Thromboprophylaxis_Description
	PX890101020000	more escription: ____________________________________________________ show less	N/A
PX890101_Thromboprophylaxis_Dose
	PX890101010200	Dose: ________________________________	N/A
PX890101_Thromboprophylaxis_Type
	PX890101010100	Type: ________________________________	N/A

SCD Pregnancy

Measure Name

Thromboprophylaxis

Release Date

August 5, 2024

Definition

Thromboprophylaxis is an intervention to prevent the formation of a blood clot and can be pharmacologic (medication-based) or non-pharmacologic (such as compression stockings or ambulation).

Purpose

This measure is useful for assessing an individual’s history of thromboprophylaxis use.  Thromboprophylaxis has been shown to reduce venous thromboembolism (VTE) development. Both pregnancy and sickle cell disease are strong risk factors for VTE, and the combined risk is reported to be 1.5–5.0 times greater than pregnancy-related VTE in the general population (Seaman et al. 2014).

Keywords

Thromboprophylaxis, blood clot prevention, deep vein thrombosis, DVT, pulmonary embolism, venous thromboembolism, VTE

Measure Protocols

Protocol ID	Protocol Name
890101	Thromboprophylaxis

Publications

There are no publications listed for this protocol.