Protocol - Relational and Item-Specific Encoding Task (RiSE)

Description

The Relational and Item-Specific Encoding Task (RiSE) is a computerized test, developed in Eprime by the Cognitive Neuroscience Test Reliability and Clinical applications for Schizophrenia (CNTRACS) consortium, which evaluates item-specific encoding and relational encoding. The subject views visual objects (pictures) and responds yes/no to whether the objects are "living" (item-specific encoding). The subject then views pairs of visual objects and responds yes/no to whether or not one item can fit into the other (relational encoding). Then the subject views visual objects and indicates whether each object was "old" or "new," responding by way of confidence level high, medium, or low (item recognition). Lastly, the subject views pairs of visual objects and responds yes/no to whether or not the pairs were presented together in the relational encoding test (associative recognition).

Specific Instructions

There are three test forms available, each with different visual objects (pictures). The tests are in English; however, since the task uses pictures instead of words, the subject does not have to speak English to perform the task.

There are a total of four neurocognitive assessments: the Computerized Neurocognitive Battery (CNB) measures Global Cognitive Functioning, the AX-Continuous Performance Test (AX-CPT) measures Context Processing, the Relational and Item-Specific Encoding task (RiSE) measures Relational Encoding and Retrieval, and the Auditory Continuous Performance Test (ACPT) battery measures Auditory Vigilance.

RiSE and AX-CPT can be run together and can be downloaded together.

RiSE can be combined with Task functional magnetic resonance imaging (fMRI) as described by Ragland et al. (2015) to assist in identifying specific neural circuits.

Availability

Limited Availability

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Protocol

Tasks can be downloaded for free from the CNTRACS website once a Request form has been completed and submitted. Link to the Request form can be found here:

http://cntracs.ucdavis.edu/download_request

Copies of the tasks, written in Eprime, can be downloaded off of the CNTRACS website at the link below:

http://cntracs.ucdavis.edu/tasks

Personnel and Training Required

The interviewer must be trained to conduct personal interviews with individuals from the general population. The interviewer must be trained and found to be competent (i.e., tested by an expert) at the completion of personal interviews. The interviewer should be trained to prompt respondents further if a "don’t know" response is provided. Training by an experienced group in administering and analyzing the results is recommended.

Equipment Needs

The PhenX Working Group acknowledges these questions are administered in a computerized format. The interviewer will require a laptop computer/handheld computer to administer this protocol. Eprime computer software is necessary to conduct this protocol.

Requirements

Requirement Category	Required
Major equipment	No
Specialized training	No
Specialized requirements for biospecimen collection	No
Average time of greater than 15 minutes in an unaffected individual	Yes

Mode of Administration

Performance-based task

Lifestage

Adolescent, Adult, Senior

Participants

Individuals 12 and older

Selection Rationale

The Cognitive Neuroscience Test Reliability and Clinical applications for Schizophrenia (CNTRACS) tasks have been used for many years. The tasks have been well studied in CNTRACS and have good test/re-test reliability. The tasks are very easy to use and have standardized instructions and a high level of subject acceptability. CNTRACS contains psychology resources that can be used by individuals who are not psychologists.

Language

English

Standards

Standard	Name	ID	Source
Human Phenotype Ontology	Memory impairment	HP:0002354	HPO

Derived Variables

None

Process and Review

Not applicable.

Protocol Name from Source

Relational and Item-Specific Encoding Task (RiSE)

Source

Ragland, J. D., Ranganath, C., Barch, D. M., Gold, J. M., Haley, B., MacDonald, A. W., III, Silverstein, S. M., Strauss, M. E., Yonelinas, A. P., & Carter, C. S. (2012). Relational and Item-Specific Encoding (RISE): Task Development and psychometric characteristics. Schizophrenia Bulletin, 38(1), 114-124. doi:10.1093/schbul/sbr146

General References

Gold, J. M., Barch, D. M., Carter, C. S., Dakin, S., Luck, S. J., MacDonald, A. W., III, Ragland, J. D., Ranganath, C., Kovacs, I., Silverstein, S. M., & Strauss, M. (2012). Clinical, functional, and intertask correlations of measures developed by the Cognitive Neuroscience Test Reliability and Clinical Applications for Schizophrenia Consortium. Schizophrenia Bulletin, 38(1), 144-152. doi:10.1093/schbul/sbr142

Ragland, J. D., Ranganath, C., Harms, M. P., Barch, D. M., Gold, J. M., Layher, E., Lesh, T., MacDonald, A. W., III, Niendam, T. A., Phillips, J., Silverstein, S. M., Yonelinas, A. P., & Carter, C. S. (2015). Multi-site fMRI study of the Relational and Item-Specific Encoding (RiSE) memory task: Imaging biomarker validation and specificity of frontal and hippocampal deficits in schizophrenia. JAMA Psychiatry, 72(9), 909-916. doi:10.1001/jamapsychiatry.2015.0276

Sheffield, J. M., Gold, J. M., Strauss, M. E., Carter, C. S., MacDonald, A. W., III, Ragland, J. D., Silverstein, S. M., & Barch, D. M. (2014). Common and specific cognitive deficits in schizophrenia: Relationships to function. Cognitive, Affective & Behavioral Neuroscience, 14(1), 161-174. doi:10.3758/s13415-013-0211-5

Strauss, M. E., McLouth, C. J., Barch, D. M., Carter, C. S., Gold, J. M., Luck, S. J., MacDonald, A. W., III, Ragland, J. D., Ranganath, C., Keane, B. P., & Silverstein S. M. (2014). Temporal stability and moderating effects of age and sex on CNTRaCS task performance. Schizophrenia Bulletin, 40(4), 835-844. doi:10.1093/schbul/sbt089

Protocol ID

660301

Variables

Export Variables

Variable Name	Variable ID	Variable Description	dbGaP Mapping

	PX660301000000	Protocol 660301 - proprietary. Check DCW for more contact. show less	N/A

Early Psychosis Translational Research

Measure Name

Relational Encoding and Retrieval

Release Date

January 17, 2017

Definition

Computer-administered task that measures cognitive functions.

Purpose

This measure assesses deficits in cognition, specifically working memory and long-term memory.

Keywords

Cognitive Neuroscience Test Reliability and Clinical applications for Schizophrenia, CNTRACS, Relational and Item-Specific Encoding Task, RiSE, retrieval, early psychosis, psychometrics, episodic memory

Measure Protocols

Protocol ID	Protocol Name
660301	Relational and Item-Specific Encoding Task (RiSE)

Publications

There are no publications listed for this protocol.