Protocol - Substance Abuse and Dependence - Past Year - Tobacco
- Alcohol - 30-Day Quantity and Frequency
- Alcohol - Lifetime Use Disorder
- Cigarette Nicotine Dependence
- Patterns of Substance Use - Adolescents
- Patterns of Substance Use - Adults - Binge-Drinking
- Screening and Severity of Substance Use Problems - Adolescents
- Screening and Severity of Substance Use Problems - Adults - Alcohol - Lifetime
- Screening and Severity of Substance Use Problems - Adults - Alcohol - Past 12 Months
- Screening and Severity of Substance Use Problems - Adults - Drugs
- Substances - 30-Day Frequency
- Substances - Lifetime Abuse and Dependence
- Tobacco - 30-Day Quantity and Frequency - Adolescent
- Tobacco - 30-Day Quantity and Frequency - Adult
Description
In a face-to-face interview, the respondent is asked several questions about nicotine dependence during the past 12 months. These responses correspond with criteria from the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) (American Psychiatric Association, 1994). The questions encompass nicotine from any source (e.g., cigarettes, cigars, a pipe, snuff, or chewing tobacco).
Specific Instructions
Questions concerning past 12-month nicotine experiences are found in Section 3A (questions 8-11) of the Alcohol Use Disorder and Associated Disabilities Interview Schedule - Fourth Edition Version (AUDADIS-IV). The questions and check items have not been renumbered, so the protocol text starts with question "8." Note that not all questions are administered to all respondents because of skip patterns in AUDADIS-IV. These questions are asked if a respondent had affirmatively answered the first question in the "Tobacco - Smoking Status" measure from the Alcohol, Tobacco and Other Substances domain, such that never smokers skip Section 3A entirely. Variable names, shown in blue, are used in the scoring algorithm for nicotine dependence diagnosis in the past 12 months.
The Substance Abuse and Addiction Working Group acknowledges that the following questions may gather sensitive information relating to the use of substances and/or illegal conduct. If the information is released, it might be damaging to an individual’s employability, lead to social stigmatization, or lead to other consequences.
Most researchers assure confidentiality as part of their informed consent process, as required by their institutional review boards. When assessing minors with these questions, it may be necessary to obtain informed consent from a parent of the adolescent. Further assurance of confidentiality may be obtained by applying to National Institutes of Health (NIH) for a Certificate of Confidentiality, which helps researchers protect the privacy of human research participants. The procedures for the Certificate of Confidentiality can be found at the Grants Policy website of the NIH: http://grants1.nih.gov/grants/policy/coc/index.htm.
Availability
Protocol
Section 3A - Tobacco Use
Column a | Column b | |
8a. The next few questions are about experiences that many people have had with using tobacco, including cigarettes, cigars, a pipe, snuff, or chewing tobacco. As I read each experience, please tell me if it has EVER happened to you as a result of using ANY of these types of tobacco. In your ENTIRE LIFE, did you EVER…(PAUSE) (Repeat phrase frequently) | b. Did this happen in the last 12 months? | |
(1) More than once want to cut down on your tobacco use? | 1 [ ] Yes → 2 [ ] No - Go to next experience | 1 [ ] Yes 2 [ ] No [s3aq8b1] |
(2) Give up or cut down on activities that you were interested in or that gave you pleasure because tobacco use was not permitted at the activity? | 1 [ ] Yes → 2 [ ] No - Go to next experience | 1 [ ] Yes 2 [ ] No [s3aq8b2] |
(3) Give up or cut down on activities that were important to you like associating with friends or relatives or attending social activities - because tobacco use was not permitted at the activity? | 1 [ ] Yes → 2 [ ] No - Go to next experience | 1 [ ] Yes 2 [ ] No [s3aq8b3] |
(4) Continue to use tobacco even though you knew it was causing you a health problem or making a health problem worse? | 1 [ ] Yes → 2 [ ] No - Go to next experience | 1 [ ] Yes 2 [ ] No [s3aq8b4] |
(5) Find yourself (chain smoking/using one pinch or plug of snuff or chewing tobacco right after another)? | 1 [ ] Yes → 2 [ ] No - Go to next experience | 1 [ ] Yes 2 [ ] No [s3aq8b5] |
(6) More than once try to stop or cut down on your tobacco use but found you couldn’t do it? | 1 [ ] Yes → 2 [ ] No - Go to next experience | 1 [ ] Yes 2 [ ] No [s3aq8b6] |
(7) Many people experience problems on occasions when they stop or cut down on their tobacco use. After stopping or cutting down on your tobacco use, did you EVER… | ||
(a) Feel depressed? | 1 [ ] Yes → 2 [ ] No - Go to next experience | 1 [ ] Yes 2 [ ] No [s3aq8b7a] |
(b) Have difficulty falling asleep or staying asleep? | 1 [ ] Yes → 2 [ ] No - Go to next experience | 1 [ ] Yes 2 [ ] No [s3aq8b7b] |
(c) Have difficulty concentrating? | 1 [ ] Yes → 2 [ ] No - Go to next experience | 1 [ ] Yes 2 [ ] No [s3aq8b7c] |
(d) Eat more than usual or gain weight? | 1 [ ] Yes → 2 [ ] No - Go to next experience | 1 [ ] Yes 2 [ ] No [s3aq8b7d] |
(e) Become easily irritated, angry, or frustrated? | 1 [ ] Yes → 2 [ ] No - Go to next experience | 1 [ ] Yes 2 [ ] No [s3aq8b7e] |
(f) Feel anxious or nervous? | 1 [ ] Yes → 2 [ ] No - Go to next experience | 1 [ ] Yes 2 [ ] No [s3aq8b7f] |
(g) Feel your heart beating more slowly than usual? | 1 [ ] Yes → 2 [ ] No - Go to next experience | 1 [ ] Yes 2 [ ] No [s3aq8b7g] |
(h) Feel more restless than usual? | 1 [ ] Yes → 2 [ ] No - Go to Check | 1 [ ] Yes 2 [ ] No [s3aq8b7h] |
CHECK ITEM 3.4 Are at least 2 items marked "Yes" in column b, 7(a) - 7(h)? | 1 [ ] Yes - Go to 7(i) 2 [ ] No - SKIP to (8) | |
(i) You just mentioned that you had some experiences after stopping or cutting down on your tobacco use in the last 12 months. Were any of these experiences very uncomfortable or upsetting to you or did they cause problems in your life like at work or school or with family or friends? | 1 [ ] Yes 2 [ ] No [s3aq8b7i] | |
(j) Did you use tobacco in the last 12 months to keep from having any of these experiences? | 1 [ ] Yes 2 [ ] No [s3aq8b7j] | |
(8) Wake up in the middle of the night to use tobacco? | 1 [ ] Yes → 2 [ ] No - Go to next experience | 1 [ ] Yes 2 [ ] No [s3aq8b8] |
(9) Often use tobacco just after getting up or shortly after getting up in the morning? | 1 [ ] Yes → 2 [ ] No - Go to next experience | 1 [ ] Yes 2 [ ] No [s3aq8b9] |
(10) Find yourself using tobacco JUST AFTER being in a situation where tobacco use was not permitted - like after being on a plane, at a meeting, or shopping at the mall? | 1 [ ] Yes → 2 [ ] No - Go to next experience | 1 [ ] Yes 2 [ ] No [s3aq8b10] |
(11) Find that you had to use much more tobacco than you once did to get the effect you wanted? | 1 [ ] Yes → 2 [ ] No - Go to next experience | 1 [ ] Yes 2 [ ] No [s3aq8b11] |
(12) Increase your use of tobacco by at least 50 percent? | 1 [ ] Yes → 2 [ ] No - Go to next experience | 1 [ ] Yes 2 [ ] No [s3aq8b12] |
(13) Have a period when you often used tobacco more than you intended to? | 1 [ ] Yes → 2 [ ] No - Go to next experience | 1 [ ] Yes 2 [ ] No [s3aq8b13] |
(14) Continue to use tobacco even though it made you nervous, jittery, anxious, or depressed? | 1 [ ] Yes → 2 [ ] No - Go to next experience | 1 [ ] Yes 2 [ ] No [s3aq8b14] |
Scoring Procedure and Interpretation
The scoring algorithms were reverse-engineered and further validated by members of the Substance Abuse and Addiction Scientific Panel and Working Group, and the results from the algorithms were found to match* the nicotine dependence diagnoses reported in the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) (Saha et al., 2010; Muthen & Asparouhov, 2006).
The variable names used in the following SAS code for nicotine dependence diagnosis correspond to the variable names shown in blue from the protocol text. The algorithms are derived from published work by NESARC investigators (Grant et al., 2004), and they are provided to assist with derivation of estimates from NESARC.
The SAS code creates NESARC-compatible dichotomous variables (with values 0 = negative and 1 = positive) for past-year nicotine dependence diagnostic criteria (p12tolerance, p12withdrawal_v2, p12intend, p12quit, p12giveup, p12time, and p12problems) and past-year nicotine dependence diagnosis (dsm4depend_p12). The nicotine withdrawal algorithm, shown below as p12withdrawal_v2, may not directly relate to withdrawal based on the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) (American Psychiatric Association, 1994). All other diagnostic criteria algorithms are directly based on DSM-IV. Nicotine withdrawal according to Criterion B of DSM-IV (American Psychiatric Association, 1994) may be captured by using p12withdrawal_dsm alone.
* For p12tolerance, a 1% difference was noted between the publication (Saha et al., 2010) and the reverse-engineered algorithm results.
SAS code
********************Dependence items******************;
p12tolerance = (s3aq8b11=1) or (s3aq8b12=1);
p12withdrawal_total = ((s3aq8b7a=1)+(s3aq8b7b=1)+(s3aq8b7c=1)+(s3aq8b7d=1)+(s3aq8b7e=1)+(s3aq8b7f=1)+(s3aq8b7g=1)+(s3aq8b7h=1));
p12withdrawal_v1=(p12withdrawal_total>3);
p12withdrawal_v2=(p12withdrawal_v1=1 or (s3aq8b7j=1 or s3aq8b8=1 or s3aq8b9=1 or s3aq8b10=1));
p12withdrawal_dsm=(p12withdrawal_v1=1 or s3aq8b7j=1);
p12intend = (s3aq8b13=1);
p12quit = (s3aq8b1=1 or s3aq8b6=1);
p12giveup = (s3aq8b2=1 or s3aq8b3=1);
p12time = (s3aq8b5=1);
p12problems = (s3aq8b4=1 or s3aq8b14=1);
***********Past 12-month dependence diagnosis***;
dsm4depend_total_p12=p12tolerance+p12withdrawal_v2+p12intend+p12quit+p12giveup+p12time+p12problems;
dsm4depend_p12 =(dsm4depend_total_p12 ge 3);
Personnel and Training Required
Interviewer must be trained and found to be competent to conduct personal interviews with individuals from the general population. Specifically, the 2-week AUDADIS training covers directed self-study, intensive classroom training, and practice interviewing. The interviewer should be trained to prompt respondents further if a "don’t know" response is provided.
Equipment Needs
Although the Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV) instrument was developed for administration by computer, the PhenX Working Group acknowledges that these questions can be administered in a noncomputerized format. Hasin et al. (1997) and Grant et al. (1995) used the AUDADIS in paper-and-pencil format; Grant et al. (2003) obtained data with the computerized format.
Requirements
Requirement Category | Required |
---|---|
Major equipment | No |
Specialized training | Yes |
Specialized requirements for biospecimen collection | No |
Average time of greater than 15 minutes in an unaffected individual | Yes |
Mode of Administration
Interviewer-administered questionnaire
Lifestage
Adult
Participants
>18 years of age
Selection Rationale
The Alcohol Use Disorder and Associated Disabilities Interview Schedule-Fourth Edition Version (AUDADIS-IV) is a fully structured diagnostic interview for alcohol and substance use disorders and their associated disabilities. AUDADIS-IV was designed by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) to be administered by lay interviewers. Questions from the AUDADIS-IV were chosen because this protocol has been used in an established epidemiological study of adults with a wide age range and different races and ethnicities (National Epidemiologic Survey on Alcohol and Related Conditions, NESARC). AUDADIS-IV questions have been validated and psychometrically tested.
Language
English, Other languages available at source
Standards
Standard | Name | ID | Source |
---|---|---|---|
Human Phenotype Ontology | Addictive behavior | HP:0030858 | HPO |
caDSR Form | PhenX PX510403 - Substance Abuse And Dependence Past Year Tobacco | 6214502 | caDSR Form |
Derived Variables
None
Process and Review
Not applicable.
Protocol Name from Source
National Epidemiologic Survey on Alcohol and Related Conditions (NESARC-WAVE 1), AUDADIS-IV
Source
National Institute on Alcohol Abuse and Alcoholism (NIAAA) National Epidemiologic Survey on Alcohol and Related Conditions. Wave 1 (NESARC-WAVE 1). Alcohol Use Disorder and Associated Disabilities Interview Schedule-Diagnostic and Statistical Manual of Mental Disorders-Fourth Edition Version (AUDADIS-IV). Section 3A Tobacco Use, Questions 8-11.
Grant, B. F., Dawson, D. A., Stinson, F. S., Chou, P. S., Kay, W., & Pickering, R. (2003) The Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV): Reliability of alcohol consumption, tobacco use, family history of depression and psychiatric diagnostic modules in a general population sample. Drug and Alcohol Dependence, 71(1), 7-16.
The reverse-engineering of the scoring algorithms reflects a collaborative effort, particularly between Dr. Arpana Agrawal (Washington University in St. Louis, Substance Abuse and Addiction Scientific Panel Member) and Alvaro Verges from the research group of Dr. Kenneth Sher (University of Missouri, Substance Abuse and Addiction Scientific Panel Chair).
General References
American Psychiatric Association. (1994). Diagnostic and Statistical Manual of Mental Disorders (4th ed.). Washington, DC.
Canino, G., Bravo, M., Ramirez, R., Febo, V. E., Rubio-Stipec, M., Fernandez, R. L., & Hasin, D. (1999). The Spanish Alcohol Use Disorder and Associated Disabilities Interview Schedule (AUDADIS): Reliability and concordance with clinical diagnoses in a Hispanic population. Journal of Studies on Alcohol, 60(6), 790-799.
Grant, B. F., Harford, T. C., Dawson, D. A., Chou, P. S., & Pickering, R. P. (1995). The Alcohol Use Disorder and Associated Disabilities Interview Schedule (AUDADIS): Reliability of alcohol and drug modules in a general population sample. Drug and Alcohol Dependence, 39(1), 37-44.
Grant, B. F., Hasin, D. S., Chou, S. P., Stinson, F. S., & Dawson, D. A. (2004). Nicotine dependence and psychiatric disorders in the United States: Results from the National Epidemiologic Survey on Alcohol and Related Conditions. Archives of General Psychiatry, 61(11), 1107-1115.
Grant, B. F., & Towle, L. (1990). Standardized diagnostic interviews for alcohol research. Alcohol Health and Research World, 14(4), 340-348.
Hasin, D., Carpenter, K. M., McCloud, S., Smith, M., & Grant, B. F. (1997). The Alcohol Use Disorder and Associated Disabilities Interview Schedule (AUDADIS): Reliability of alcohol and drug modules in a clinical sample. Drug and Alcohol Dependence, 44(2-3), 133-141.
Muthen, B., & Asparouhov, T. (2006). Item response mixture modeling: Application to tobacco dependence criteria. Addictive Behaviors, 31(6), 1050-1066.
Saha, T. D., Compton, W. M., Pulay, A. J., Stinson, F. S., Ruan, W. J., & Grant, B. F. (2010). Dimensionality of DSM-IV nicotine dependence in a national sample: An item response theory application. Drug and Alcohol Dependence, 108(1-2), 21-28.
Ruan, W. J., Goldstein, R. B., Chou, S. P., Smith, S. M., Saha, T. D., Pickering, R. P., Dawson, D. A., Huang, B., Stinson, F. S., & Grant, B. F. (2008). The Alcohol Use Disorder and Associated Disabilities Interview Schedule-IV (AUDADIS-IV): Reliability of new psychiatric diagnostic modules and risk factors in a general population sample. Drug and Alcohol Dependence, 92(1-3), 27-36.
Protocol ID
510403
Variables
Export VariablesVariable Name | Variable ID | Variable Description | dbGaP Mapping | |
---|---|---|---|---|
PX510403_After_Stopping_Angry_Frustrated | ||||
PX510403070501 | After stopping or cutting down on your more | N/A | ||
PX510403_After_Stopping_Angry_Frustrated_Last12Months | ||||
PX510403070502 | After stopping or cutting down on your more | N/A | ||
PX510403_After_Stopping_Anxious_Nervous | ||||
PX510403070601 | After stopping or cutting down on your more | N/A | ||
PX510403_After_Stopping_Anxious_Nervous_Last12Months | ||||
PX510403070602 | After stopping or cutting down on your more | N/A | ||
PX510403_After_Stopping_Depressed | ||||
PX510403070101 | After stopping or cutting down on your more | N/A | ||
PX510403_After_Stopping_Depressed_Last12Months | ||||
PX510403070102 | After stopping or cutting down on your more | N/A | ||
PX510403_After_Stopping_Difficulty_Concentrating | ||||
PX510403070301 | After stopping or cutting down on your more | N/A | ||
PX510403_After_Stopping_Difficulty_Concentrating_Last12Months | ||||
PX510403070302 | After stopping or cutting down on your more | N/A | ||
PX510403_After_Stopping_Gain_Weight | ||||
PX510403070401 | After stopping or cutting down on your more | N/A | ||
PX510403_After_Stopping_Gain_Weight_Last12Months | ||||
PX510403070402 | After stopping or cutting down on your more | N/A | ||
PX510403_After_Stopping_Restless | ||||
PX510403070801 | After stopping or cutting down on your more | N/A | ||
PX510403_After_Stopping_Restless_Last12Months | ||||
PX510403070802 | After stopping or cutting down on your more | N/A | ||
PX510403_After_Stopping_Sleepless | ||||
PX510403070201 | After stopping or cutting down on your more | N/A | ||
PX510403_After_Stopping_Sleepless_Last12Months | ||||
PX510403070202 | After stopping or cutting down on your more | N/A | ||
PX510403_After_Stopping_Slow_Heartbeat | ||||
PX510403070701 | After stopping or cutting down on your more | N/A | ||
PX510403_After_Stopping_Slow_Heartbeat_Last12Months | ||||
PX510403070702 | After stopping or cutting down on your more | N/A | ||
PX510403_Chain_Smoking_Last12Months | ||||
PX510403050200 | In your ENTIRE LIFE, did you EVER... (PAUSE) more | N/A | ||
PX510403_Check_Item | ||||
PX510403070900 | CHECK ITEM 3.4: Are at least 2 items marked more | N/A | ||
PX510403_Continue_Tobacco_HealthProblems_Last12Months | ||||
PX510403040200 | In your ENTIRE LIFE, did you EVER... (PAUSE) more | N/A | ||
PX510403_Continue_Tobacco_Made_Nervous | ||||
PX510403140100 | Continue to use tobacco even though it made more | N/A | ||
PX510403_Continue_Tobacco_Made_Nervous_Last12Months | ||||
PX510403140200 | Continue to use tobacco even though it made more | N/A | ||
PX510403_CouldNot_CutOut_Tobacco_Last12Months | ||||
PX510403060200 | In your ENTIRE LIFE, did you EVER... (PAUSE) more | N/A | ||
PX510403_CutDown_ImportantActivities_TobaccoUse_NotPermitted_Last12Months | ||||
PX510403030200 | In your ENTIRE LIFE, did you EVER... (PAUSE) more | N/A | ||
PX510403_CutDown_InterestingActivities_TobaccoUse_NotPermitted_Last12Months | ||||
PX510403020200 | In your ENTIRE LIFE, did you EVER... (PAUSE) more | N/A | ||
PX510403_EntireLife_Chain_Smoking | ||||
PX510403050100 | In your ENTIRE LIFE, did you EVER... (PAUSE) more | N/A | ||
PX510403_EntireLife_Continue_Tobacco_HealthProblems | ||||
PX510403040100 | In your ENTIRE LIFE, did you EVER... (PAUSE) more | N/A | ||
PX510403_EntireLife_CouldNot_CutOut_Tobacco | ||||
PX510403060100 | In your ENTIRE LIFE, did you EVER... (PAUSE) more | Variable Mapping | ||
PX510403_EntireLife_CutDown_ImportantActivities_TobaccoUse_NotPermitted | ||||
PX510403030100 | In your ENTIRE LIFE, did you EVER... (PAUSE) more | N/A | ||
PX510403_EntireLife_CutDown_InterestingActivities_TobaccoUse_NotPermitted | ||||
PX510403020100 | In your ENTIRE LIFE, did you EVER... (PAUSE) more | N/A | ||
PX510403_EntireLife_WantTo_CutDown_TobaccoUse | ||||
PX510403010100 | In your ENTIRE LIFE, did you EVER... (PAUSE) more | N/A | ||
PX510403_Experiences_CauseProblems_WorkSchool | ||||
PX510403071001 | You just mentioned that you had some more | N/A | ||
PX510403_Experiences_CauseProblems_WorkSchool_Last12Months | ||||
PX510403071002 | You just mentioned that you had some more | N/A | ||
PX510403_Use_50Percent_More_Tobacco | ||||
PX510403120100 | Increase your use of tobacco by at least 50 more | N/A | ||
PX510403_Use_50Percent_More_Tobacco_Last12Months | ||||
PX510403120200 | Increase your use of tobacco by at least 50 more | N/A | ||
PX510403_Use_More_Tobacco_Effect | ||||
PX510403110100 | Find that you had to use much more tobacco more | N/A | ||
PX510403_Use_More_Tobacco_Effect_Last12Months | ||||
PX510403110200 | Find that you had to use much more tobacco more | N/A | ||
PX510403_Use_More_Tobacco_ThanIntended | ||||
PX510403130100 | Have a period when you often used tobacco more | Variable Mapping | ||
PX510403_Use_More_Tobacco_ThanIntended_Last12Months | ||||
PX510403130200 | Have a period when you often used tobacco more | N/A | ||
PX510403_Use_Tobacco_Just_After | ||||
PX510403100100 | Find yourself using tobacco JUST AFTER being more | N/A | ||
PX510403_Use_Tobacco_Just_After_Last12Months | ||||
PX510403100200 | Find yourself using tobacco JUST AFTER being more | N/A | ||
PX510403_Use_Tobacco_Prevent_Problems | ||||
PX510403071101 | Did you use tobacco in the last 12 months to more | N/A | ||
PX510403_Use_Tobacco_Upon_Waking | ||||
PX510403090100 | Often use tobacco just after getting up or more | N/A | ||
PX510403_Use_Tobacco_Upon_Waking_Last12Months | ||||
PX510403090200 | Often use tobacco just after getting up or more | N/A | ||
PX510403_Wake_Up_Use_Tobacco | ||||
PX510403080100 | Wake up in the middle of the night to use tobacco? | N/A | ||
PX510403_Wake_Up_Use_Tobacco_Last12Months | ||||
PX510403080200 | Wake up in the middle of the night to use more | N/A | ||
PX510403_WantTo_CutDown_TobaccoUse_Last12Months | ||||
PX510403010200 | In your ENTIRE LIFE, did you EVER... (PAUSE) more | N/A |
Measure Name
Substance Abuse and Dependence - Past Year
Release Date
June 7, 2012
Definition
Interviewer-administered questions to determine whether the respondent has experienced symptoms of alcohol abuse and dependence, nicotine dependence, or substance abuse and dependence in the past year (i.e., past 12 months).
Purpose
This measure uses the 12-month criteria from the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), to evaluate alcohol abuse and dependence, nicotine dependence, or substance abuse and dependence.
Keywords
Alcohol Use Disorder and Associated Disabilities Interview Schedule, AUDADIS, National Institute on Alcohol Abuse and Alcoholism, NIAAA, Diagnostic and Statistical Manual of Mental Disorder, DSM-5, National Epidemiologic Survey on Alcohol and Related Conditions, NESARC
Measure Protocols
Protocol ID | Protocol Name |
---|---|
510403 | Substance Abuse and Dependence - Past Year - Tobacco |
510404 | Substance Abuse and Dependence - Past Year - Alcohol |
510405 | Substance Abuse and Dependence - Past Year - Drugs |
Publications
Felicione, N. J., et al. (2022) Timing of smoking cessation treatment integrated into outpatient treatment with medications for opioid use disorder: Feasibility trial. Journal of Substance Abuse Treatment. 2022 January; 132: 8. doi: 10.1016/j.jsat.2021.108579
Dawes, K., et al. (2021) Epigenetic Analyses of Alcohol Consumption in Combustible and Non-Combustible Nicotine Product Users. Epigenomes. 2021 September; 5(3): 18. doi: 10.3390/epigenomes5030018
Kohno, M., et al. (2019) Effects of Naltrexone on Large-Scale Network Interactions in Methamphetamine Use Disorder. Frontiers in Psychiatry. 2019 September; 10: Article No.: 603. doi: 10.3389/fpsyt.2019.00603