Research Domain - Pregnancy

Release Date:

January 31, 2017

Scope of Domain:
Scope Elements Final Protocols To Toolkit (19)
Gestational Age Gestational Age
Fetal Growth Fetal Growth Assessment
Mode of Delivery
  • Event that initiated immediate birth process
Mode of Delivery
Mode of Conception Mode of Conception
Pregnancy History
  • Live birthday, losses, etc
  • Family History
Current Pregnancy Status
Family History of Pregnancy Complications
Issues of Premature Delivery
  • Biomarkers, inflammation
Concentrations of Flame Retardants
Concentrations of Phenols and Parabens
Concentrations of Polychlorinated Biphenyls (PCBs) and Persistent Pesticides
Concentrations of Trace Metals
Biological responses to environment See biomarkers
Federated Bio-bank, Standardize Approaches (e.g., blood spot cards for environmental monitoring, DNA, collect hair, teeth to capture exposures) See biomarkers
Biomonitoring during Pregnancy and other Sensors See biomarkers
Prenatal Care
  • Provider visits
  • Social Media
  • Personal behavior during pregnancy: physical activity, diet sleep
Adequacy of Prenatal Care
Health and Wellness Before, During, and After Pregnancy
Exposures during Pregnancy
  • Developmental toxicants
  • Smoking, including second hand smoke
  • Alcohol during pregnancy
See biomarkers
Addressed elsewhere in the PhenX Toolkit
Pharmacological
  • antibiotic use, psychotropic medications, antiepileptic medications
Addressed elsewhere in the PhenX Toolkit
Placental Characteristics Placental Assessment (Supplemental Information)
Complications of Pregnancy
  • Growth restriction
Difficulties in Pregnancy
Diabetes, Pre-eclampsia Gestational Diabetes
Pregnancy Weight Gain: Total and Serial Addressed elsewhere in the PhenX Toolkit
Pre-pregnancy BMI, Weight, Height Addressed elsewhere in the PhenX Toolkit
Diet Addressed elsewhere in the PhenX Toolkit
Nutrients - Vitamins, Folic Acid, Other Supplements Addressed elsewhere in the PhenX Toolkit
Psychological/psychiatric Conditions Prenatal and Postpartum Depression
Psychological Stress Addressed elsewhere in the PhenX Toolkit
Working Group Roster:

WG Members:

Siobhan Dolan, MD, MPH, Chair
Albert Einstein College of Medicine
Bronx, NY
Cande Ananth, PhD
Columbia University
New York, NY
Patrick Catalano, MD
Case Western Reserve University
MetroHealth Medical Center
Cleveland, OH
Erin Hines, PhD
U.S. Environmental Protection Agency
Research Triangle Park, NC
Ann Kinga Malinowski, MD
Mount Sinai Hospital
Toronto, ON
Russ Kirby, PhD
University of South Florida
Tampa, FL
Mark Klebanoff, MD, MPH
Nationwide Children's Hospital
Columbus, OH
John J. Mulvihill, MD
National Human Genome Research Institute (NHGRI)
Bethesda, MD
Hyagriv Simhan, MD, MS
Magee-Women's Research Institute
Pittsburgh, PA

SC Liaison, WG Manager and WG Supervisor:

Rosalind J. Wright, MD, MPH, SC Liaison
Icahn School of Medicine
New York, NY
Lisa Cox, MS, WG Manager
RTI International
Atlanta, GA
Michael Phillips, MS, WG Supervisor
RTI International
Research Triangle Park, NC